Gut Microbiota Parameters Potentially Useful in Clinical Perspective

Pierro, Francesco Di

doi:10.3390/microorganisms9112402

Cited by 35 publications

(30 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with our results, other studies have reported that Fusobacteria are associated with host lipid metabolism [ 61 ]. Bacteroidetes also are Gram-negative anaerobic bacteria [ 62 ] that are closely associated with the occurrence and development of intestinal inflammatory diseases [ 63 ]. In this study, transport stress resulted in a reduced abundance of Bacteroidetes and an increase in the Firmicutes/Bacteroidetes ratio in hybrid yellow catfish.…”

Section: Discussionmentioning

confidence: 99%

Integrated Transcriptome and 16S rDNA Analyses Reveal That Transport Stress Induces Oxidative Stress and Immune and Metabolic Disorders in the Intestine of Hybrid Yellow Catfish (Tachysurus fulvidraco♀ × Pseudobagrus vachellii♂)

Zheng

Tao

et al. 2022

Antioxidants

View full text Add to dashboard Cite

Live fish are often transported in aquaculture. To explore the effects of transport stress, hybrid yellow catfish (Tachysurus fulvidraco♀ × Pseudobagrus vachellii♂) were subjected to simulated transport treatments (0–16 h) with 96 h of recovery after the 16-h transport treatment, and intestinal biochemical parameters, the transcriptome, and gut microbiota were analyzed. Transportation affected the number of mucus cells and led to oxidative stress in the intestine, which activated immune responses. Changes in lipid metabolism reflected metabolic adaptation to oxidative stress. Toll-like receptor signaling, peroxisome proliferator-activated receptor signaling, and steroid biosynthesis pathways were involved in the transport stress response. Gene expression analyses indicated that transport-induced local immune damage was reversible, whereas disordered metabolism recovered more slowly. A 16S rDNA analysis revealed that transport stress decreased the alpha diversity of the gut microbiota and disrupted its homeostasis. The dominant phyla (Fusobacteria, Bacteroidetes) and genera (Cetobacterium, Barnesiellaceae) were involved in the antioxidant, immune, and metabolic responses of the host to transportation stress. Correlation analyses suggested that gut microbes participate in the transport stress response and the host–microbiota interaction may trigger multiple events in antioxidant, immune, and metabolic pathways. Our results will be useful for optimizing transport processes.

show abstract

Section: Discussionmentioning

confidence: 99%

Integrated Transcriptome and 16S rDNA Analyses Reveal That Transport Stress Induces Oxidative Stress and Immune and Metabolic Disorders in the Intestine of Hybrid Yellow Catfish (Tachysurus fulvidraco♀ × Pseudobagrus vachellii♂)

Zheng

Tao

et al. 2022

Antioxidants

View full text Add to dashboard Cite

show abstract

“…In this study, we found that DEX increased the relative quantity of Firmicutes and the Firmicutes to Bacteroidetes ratio, further reversing the intestinal I/R-induced microbiota abnormalities. Firmicutes and Bacteroidetes are 2 major phyla in normal intestinal microbiota, and the Firmicutes to Bacteroidetes ratio has been associated with several pathological conditions ( 36 ). Huang et al found that a high-fiber diet increased the quantity of Firmicutes and reduced the incidence of rectal cancer ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Use of dexmedetomidine to alleviate intestinal ischemia-reperfusion injury via intestinal microbiota modulation in mice

Dong¹,

Hu²,

Deng³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

Background: Intestinal ischemia-reperfusion (I/R) injury is a serious condition with unacceptable mortality rates. Our previous study revealed a protective effect of dexmedetomidine (DEX) on intestinal I/R injury, but its underlying mechanism remains unclear. Gut microbiota imbalance is associated with the progression of I/R injury. We hypothesized that DEX would attenuate intestinal I/R injury via modulating gut microbiota. Methods: An I/R injury model was established in C57BL/6 mice in the presence or absence of DEX preconditioning. Some mice were treated with antibiotics to deplete intestinal bacteria. Fecal microbiota transplantation (FMT) was performed by transplanting the feces of DEX-pretreated mice into a new batch of I/R mice. We analyzed the expression of Bacteroidetes and Firmicutes in feces, survival rate, and inflammatory cytokines. Results: DEX reversed I/R-induced bacterial abnormalities by increasing the ratio of Firmicutes to Bacteroidetes [DEX + I/R 3.02±0.36 vs. normal saline (NS) + I/R 0.82±0.15; 95% CI: 0.80-3.60; P<0.05] and was accompanied by increased 72-hour survival (0.40±0.16 vs. 0.10±0.09; P<0.05). The protective effect of DEX did not significantly differ from that of DEX + antibiotics. Furthermore, the bacteria of the DEXpretreated mice decreased the release of inflammatory factors.Conclusions: This study revealed that DEX can alleviate intestinal I/R injury through a microbiotarelated mechanism, providing a potential avenue for the management of intestinal I/R injury.

show abstract

“…Smoking tobacco is reported as the gut microbiome alteration promotor. In the human study, the model exhibited the elevation of most gram-negative microbes: Firmicutes and Proteobacteria, whereas decreasing anaerobe microbe Bacteroidetes [43]- [46]. This alteration is associated with LPS high prevalence, increasing TLR-4 mRNA expression, signaling VN through α5 nAChR resulting in proinflammatory mediator secretion ISSN: 2252-8938 …”

Section: 𝑅 =mentioning

confidence: 95%

Correlation between nicotine dependence and inflammatory biomarkers in Thai smokers: Eight weeks of synbiotic intervention

Lalitsuradej

Pratummas

Sittiprapaporn

et al. 2022

IJ-AI

View full text Add to dashboard Cite

Cigarette smoke contains thousands of man-made substances, and many may contribute to addiction and inflammation. This study examined the effect of synbiotics on the Fagerstrom test for nicotine dependence (FTND) and inflammatory markers in Thai smokers. 14 smokers with a Nicotine Dependence Fagerstrom Test scores of 4 or higher and no pregnancy or lactation history participated in this study. We gave them surveys about the FTND and continued blood tests for Lipopolysaccharide (LPS), lactulose and mannitol ratios (LMR), Quinolinic acid (QA), and 5-hydroindoleacetic acid (5-HIAA) to record inflammatory marker levels and leaky gut information. Pearson's R-values for LPS and LMR were 0.444 and -0.465. FTND showed a positive correlation with LPS and a negative correlation with leaky gut, but both relationships were weak due to no correlation for LPS but leaky gut. The R2 of the LPS correlation coefficient was 0.197, p = 0.112, and the R2 of the leaky gut correlation was 0.217, p 0.001. FTND, LMR, and QA were significantly reduced, while 5-HIAA was elevated. Further investigation is needed to determine the association between smoking and inflammation. In conclusion, synbiotics improved FTND, gut permeability, and inflammation.

show abstract

Gut Microbiota Parameters Potentially Useful in Clinical Perspective

Cited by 35 publications

References 98 publications

Integrated Transcriptome and 16S rDNA Analyses Reveal That Transport Stress Induces Oxidative Stress and Immune and Metabolic Disorders in the Intestine of Hybrid Yellow Catfish (Tachysurus fulvidraco♀ × Pseudobagrus vachellii♂)

Integrated Transcriptome and 16S rDNA Analyses Reveal That Transport Stress Induces Oxidative Stress and Immune and Metabolic Disorders in the Intestine of Hybrid Yellow Catfish (Tachysurus fulvidraco♀ × Pseudobagrus vachellii♂)

Use of dexmedetomidine to alleviate intestinal ischemia-reperfusion injury via intestinal microbiota modulation in mice

Correlation between nicotine dependence and inflammatory biomarkers in Thai smokers: Eight weeks of synbiotic intervention

Contact Info

Product

Resources

About