Gut microbiota partially mediates the effects of fine particulate matter on type 2 diabetes: Evidence from a population-based epidemiological study

Liu, Tao; Chen, Xiaojiao; Xu, Yanjun; Wu, Wei; Tang, Wenli; Chen, Zihui; Ji, Guiyuan; Peng, Jingyi; Jiang, Qi; Xiao, Jianpeng; Li, Xing; Zeng, Weilin; Xu, Xiaojun; Hu, Jianxiong; Lee, Hyewon; Zou, Fei; Du, Qingfeng; Zhou, Hongwei; He, Yan; Ma, Wenjun

doi:10.1016/j.envint.2019.05.076

Cited by 106 publications

(90 citation statements)

References 30 publications

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“…The genera observed in our study were similar to those observed in humans who smoked and were exposed to air pollution (Hosgood et al, 2014;Shen et al, 2016;Li et al, 2019;Qin et al, 2019). Chronic PM 2.5 exposure altered microbiota richness and induced abnormalities in glucose homeostasis (Li et al, 2020), which correlated with diabetes development (Liu et al, 2018(Liu et al, , 2019. Although these studies revealed the link between PM 2.5 and glucose-metabolic effects, the underlying mechanism of microbiota in the regulation of host glucose homeostasis needs further investigations.…”

Section: Discussionsupporting

confidence: 78%

Fine Particulate Matter Exposure Alters Pulmonary Microbiota Composition and Aggravates Pneumococcus-Induced Lung Pathogenesis

Chen

Lin

et al. 2020

Front. Cell Dev. Biol.

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Exposure to fine particulate matter (PM) with aerodynamic diameter ≤2.5 µm (PM 2.5) is closely correlated with respiratory diseases. Microbiota plays a key role in maintaining body homeostasis including regulation of host immune status and metabolism. As reported recently, PM 2.5 exposure causes microbiota dysbiosis and thus promotes disease progression. However, whether PM 2.5 alters pulmonary microbiota distribution and aggravates bacteria-induced pathogenesis remains unknown. In this study, we used mouse experimental models of PM 2.5 exposure combined with Streptococcus pneumonia infection. We characterized the airway microbiota of bronchoalveolar lavage fluid (BALF) by sequencing the 16S rRNA V3-V4 amplicon on the Illumina MiSeq platform, followed by a combination of bioinformatics and statistical analyses. Shannon-diversity index, observed ASVs, and Fisher's diversity index indicated that microbiota richness was significantly decreased in the mice treated with either PM 2.5 or pneumococcus when compared with the control group. The genera Streptococcus, Prevotella, Leptotrichia, and Granulicatella were remarkably increased in mice exposed to PM 2.5 combined with pneumococcal infection as compared to mice with pneumococcal infection alone. Histopathological examination exhibited that a more pronounced inflammation was present in lungs of mice treated with PM 2.5 and pneumococcus than that in mouse groups exposed to either PM 2.5 or pneumococcal infection alone. Our results demonstrate that PM 2.5 alters the microbiota composition, thereby enhancing susceptibility to pneumococcal infection and exacerbating lung pathogenesis.

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Section: Discussionsupporting

confidence: 78%

Fine Particulate Matter Exposure Alters Pulmonary Microbiota Composition and Aggravates Pneumococcus-Induced Lung Pathogenesis

Chen

Lin

et al. 2020

Front. Cell Dev. Biol.

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“…Recent studies have suggested a role for the gut microbiota in the development of respiratory diseases [21], although the connection between the lung and the gut is poorly understood. In the present study, we found that PM exposure was associated with decreased abundance and diversity in bacterial populations, similar to the effects reported for ne PM on diabetes and obesity [22][23][24]. These data from epidemiological and animal studies suggest that long-term exposure to PM causes gut microbiota dysbiosis and may subsequently contribute to increased risk of diabetes and obesity.…”

Section: Discussionsupporting

confidence: 88%

Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

Yang

Liao

et al. 2020

Preprint

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Background: The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown.Methods: Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24 weeks. We performed pulmonary inflammation evaluation, morphometric measurements, and lung function analysis in rat lung at three different times points during exposure. Lung and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified.Results: After a 24-week PM exposure, rats exhibited pulmonary inflammation and pathological changes characteristic of COPD. The control and PM exposure (BMF and MVE) groups showed similar microbial diversity and composition in rat lung. However, the gut microbiota after 24 weeks PM exposure was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide.Conclusion: Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.

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“…Recent studies have suggested a role for the gut microbiota in the development of respiratory diseases such as asthma, pneumonia, and acute respiratory distress syndrome [9,20,21], although the connection between the lung and the gut is poorly understood. In the present study, we found that PM exposure was associated with decreased abundance and diversity in bacterial populations, similar to the effects reported for ne PM on diabetes and obesity [22][23][24]. These data from epidemiological and animal studies suggest that long-term exposure to PM causes gut microbiota dysbiosis and may subsequently contribute to increased risk of diabetes and obesity [22,23].…”

Section: Discussionsupporting

confidence: 88%

Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

Yang

Liao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The role of the gut microbiota in the pathogenesis of chronic obstructive pulmonary disease following exposure to ambient particulate matter is largely unknown. We hypothesized that exposure alters gut microbial composition and metabolites and may involved in the pathogenesis of chronic obstructive pulmonary disease.Methods: Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel, or motor vehicle exhaust for 4, 12, and 24 weeks. Lung tissue was assessed histologically and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified. Results: After a 24-week exposure to particulate matter, rats exhibited pulmonary inflammation and pathological changes characteristic of chronic obstructive pulmonary disease. The gut microbiome was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide. Conclusion: Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.

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Gut microbiota partially mediates the effects of fine particulate matter on type 2 diabetes: Evidence from a population-based epidemiological study

Cited by 106 publications

References 30 publications

Fine Particulate Matter Exposure Alters Pulmonary Microbiota Composition and Aggravates Pneumococcus-Induced Lung Pathogenesis

Fine Particulate Matter Exposure Alters Pulmonary Microbiota Composition and Aggravates Pneumococcus-Induced Lung Pathogenesis

Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

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