Gut Microbiota Plays a Central Role to Modulate the Plasma and Fecal Metabolomes in Response to Angiotensin II

Cheema, Muhammad Umar; Pluznick, Jennifer L.

doi:10.1161/hypertensionaha.119.13155

Cited by 79 publications

(71 citation statements)

References 43 publications

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“…Low blood calcium may stimulate renin release and consequently increase the levels of angiotensin II and aldosterone [6], which are responsible for regulating BP. Recent studies revealed that angiotensin II-induced HTN is associated with gut microbial composition and metabolites [7,8].…”

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confidence: 99%

Characteristics of the urinary microbiome in kidney stone patients with hypertension

et al. 2020

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Background: Kidney stone disease (KSD) is more common in individuals with hypertension (HTN) than in individuals with normotension (NTN). Urinary dysbiosis is associated with urinary tract disease and systemic diseases. However, the role of the urinary microbiome in KSD complicated with HTN remains unclear. Methods: This study investigated the relationship between the pelvis urinary microbiome and blood pressure (BP) in patients with KSD co-occurring with HTN (KSD-HTN) and healthy controls (HC) by conducting 16S rRNA gene sequencing of bacteria in urine samples. The urine samples were collected (after bladder disinfection) from 50 patients with unilateral kidney calcium stones and NTN (n = 12), prehypertension (pHTN; n = 11), or HTN (n = 27), along with 12 HCs. Results: Principal coordinates analysis showed that there were significant differences in the urinary microbiomes not only between KSD patients and HCs but also between KSD-pHTN or KSD-HTN patients and KSD-NTN patients. Gardnerella dominated in HCs, Staphylococcus dominated in KSD-NTN patients and Sphingomonas dominated in both KSD-pHTN and KSD-HTN patients. The abundance of several genera including Acidovorax, Gardnerella and Lactobacillus was correlated with BP. Adherens junction and nitrogen and nucleotide metabolism pathways, among others, were associated with changes in BP. Conclusions: The findings suggest that patients with KSD complicated with HTN have a unique urinary microbiome profile and that changes in the microbiome may reflect disease progression and may be useful to monitor response to treatments.

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confidence: 99%

Characteristics of the urinary microbiome in kidney stone patients with hypertension

et al. 2020

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“…However, some of these compounds were nearly undetected in GF mice implying that they are dependent on the gut microbiota and that gut microbial production is downregulated with Ang II treatment. Interestingly, the authors noted that several of the metabolites measured in Conv and GF animals were different between sexes [35]. Also, it was found that the gut microbiota from specific pathogen-free and non-obese diabetic male mice protected the immature female recipients from type 1 diabetes by altering gut microbiota, elevating testosterone, reducing islet inflammation and autoantibody production [36].…”

Section: Discussionmentioning

confidence: 99%

Microbiota are critical for vascular physiology: Germ-free status weakens contractility and induces sex-specific vascular remodeling in mice

Edwards

Roy

Tomcho

et al. 2020

Vascular Pharmacology

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Commensal microbiota within a holobiont contribute to the overall health of the host via mutualistic symbiosis. Disturbances in such symbiosis is prominently correlated with a variety of diseases affecting the modern society of humans including cardiovascular diseases, which are the number one contributors to human mortality. Given that a hallmark of all cardiovascular diseases is changes in vascular function, we hypothesized that depleting microbiota from a holobiont would induce vascular dysfunction. To test this hypothesis, young mice of both sexes raised in germ-free conditions were examined vascular contractility and structure. Here we observed that male and female germ-free mice presented a decrease in contraction of resistance arteries. These changes were more pronounced in germ-free males than in germ-free females mice. Furthermore, there was a distinct change in vascular remodeling between males and females germ-free mice. Resistance arteries from male germ-free mice demonstrated increased vascular stiffness, as shown by the leftward shift in the stress-strain curve and inward hypotrophic remodeling, a characteristic of chronic reduction in blood flow. On the other hand, resistance arteries from germ-free female mice were similar in the stress-strain curves to that of conventionally raised mice, but were distinctly different and showed outward hypertrophic remodeling, a characteristic seen in aging.

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“…Shannon's index was used as α-diversity metric and computed using mothur (v 1.43.0) (Schloss et al, 2009). Bray-Curtis dissimilarity was used as β-diversity metric and computed using vegdist of the vegan package in R. The mouse fecal microbiome data were from Cheema et al (2019). The human fecal microbiome data were 16S rRNA data from 106 healthy individuals (Shagam et al, in preparation).…”

Section: Computing Nucleotide Diversities Nucleotide Diversities Betmentioning

confidence: 99%

An ancient deletion in the ABO gene affects the composition of the porcine microbiome by altering intestinal N-acetyl-galactosamine concentrations

Yang

Huang

et al. 2020

Preprint

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SummaryWe have generated a large heterogenous stock population by intercrossing eight divergent pig breeds for multiple generations. We have analyzed the composition of the intestinal microbiota at different ages and anatomical locations in > 1,000 6th- and 7th- generation animals. We show that, under conditions of exacerbated genetic yet controlled environmental variability, microbiota composition and abundance of specific taxa (including Christensenellaceae) are heritable in this monogastric omnivore. We fine-map a QTL with major effect on the abundance of Erysipelotrichaceae to chromosome 1q and show that it is caused by a common 2.3-Kb deletion inactivating the ABO acetyl-galactosaminyl-transferase gene. We show that this deletion is a trans-species polymorphism that is ≥3.5 million years old and under balancing selection. We demonstrate that it acts by decreasing the concentrations of N-acetyl-galactosamine in the cecum thereby reducing the abundance of Erysipelotrichaceae strains that have the capacity to import and catabolize N-acetyl-galactosamine.

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Gut Microbiota Plays a Central Role to Modulate the Plasma and Fecal Metabolomes in Response to Angiotensin II

Abstract: Supplemental Digital Content is available in the text.

Cited by 79 publications

References 43 publications

Characteristics of the urinary microbiome in kidney stone patients with hypertension

Characteristics of the urinary microbiome in kidney stone patients with hypertension

Microbiota are critical for vascular physiology: Germ-free status weakens contractility and induces sex-specific vascular remodeling in mice

An ancient deletion in the ABO gene affects the composition of the porcine microbiome by altering intestinal N-acetyl-galactosamine concentrations

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