Gut Microbiota Richness and Composition and Dietary Intake of Overweight Pregnant Women Are Related to Serum Zonulin Concentration, a Marker for Intestinal Permeability

Mokkala, Kati; Röytiö, Henna; Munukka, Eveliina; Pietilä, Sami; Ekblad, Ulla; Rönnemaa, Tapani; Eerola, Erkki; Laiho, Asta; Laitinen, Kirsi

doi:10.3945/jn.116.235358

Cited by 118 publications

(122 citation statements)

References 37 publications

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“…With leaky gut, junctions, composed of various proteins that link adjacent intestinal epithelial cells, are weak and fail to act as an integral barrier to migrating pathogens (Power et al, 2014). Increased intestinal permeability is hypothesized to be the mechanism by which a dysbiotic gut is linked with low-grade inflammatory disorders like obesity and its associated conditions, insulin-resistance and Type 2 diabetes mellitus (Mokkala et al, 2016). High permeability allows the leakage of bacteria, and/or bacterial components like the lipopolysaccharides (LPS) contained in the cell walls of gram-negative bacteria, thus inducing a deleterious systemic inflammatory condition called metabolic endotoxemia (Cani, Osto, Geurts, & Everard, 2012).…”

Section: An Overview Of the Gut Microbiomementioning

confidence: 99%

The Maternal Gut Microbiome During Pregnancy

Edwards

Cunningham

Dunlop

et al. 2017

McN: The American Journal of Maternal/Child Nursing

155

115

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The gut microbiome is a critical component of an individual’s metabolism and overall health. The prenatal period is marked by unique inflammatory and immune changes that alter maternal gut function and bacterial composition as the pregnancy advances. The composition of the maternal gut microbiome contributes to obstetric outcomes with long-term health sequelae for mother and child. Estrogen and progesterone also impact gut function, especially during the prenatal period. These physiologic changes in pregnancy allow for adjustments in maternal metabolism and weight necessary to support the pregnancy. This article will review the normal hormonal, metabolic and immunologic changes to the maternal gut microbiome throughout the prenatal period, in addition to relevant implications for nurses providing care for pregnant women.

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Section: An Overview Of the Gut Microbiomementioning

confidence: 99%

The Maternal Gut Microbiome During Pregnancy

Edwards

Cunningham

Dunlop

et al. 2017

McN: The American Journal of Maternal/Child Nursing

155

115

View full text Add to dashboard Cite

show abstract

“…Circulating zonulin and lipopolysaccharides have been positively associated with obesity, measures of inflammation, and deranged glycemia [51–53]. Among overweight pregnant women, those with greater serum zonulin have been shown to have lower microbial species richness, higher abundance of Bacteroides and Blautia , and lower abundance of Faecalibacterium prausnitzii , a short chain fatty acid producer [54]. …”

Section: Maternal Microbiome and Metabolic Disorders In Pregnancy: Pomentioning

confidence: 99%

Charting the Maternal and Infant Microbiome: What Is the Role of Diabetes and Obesity in Pregnancy?

Singh

Mueller

2017

Curr Diab Rep

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Purpose of Review The purpose of this review is to summarize the evidence on whether diabetes, obesity, and related metabolic derangements during pregnancy are associated with the maternal and infant microbiomes, and to identify gaps in the literature and offer guidance on future research on this topic. Recent Findings We found circumstantial evidence from four observational studies that the maternal gut microbiome was associated with either pre-pregnancy body mass index, gestational weight gain, gestational diabetes, and/or related metabolic biomarkers in pregnancy; we did not identify any studies that examined whether the vaginal microbiome varied according to these metabolic parameters. Maternal diabetes (in one study) and pregnancy weight status (in three studies) were found to be associated with the infant offspring gut microbiome, although some associations only appeared in certain cohort strata. Patterns of association across both maternal and infant microbiome studies, however, lacked consistency, which may owe to biologic or technical differences, or to the lack of control for important confounders or effect modifiers (e.g., delivery mode in infant microbiome studies). Summary Metabolic diseases in pregnancy, such as diabetes and obesity, may be associated with the maternal and infant microbiomes, but there is a need for large prospective studies of mother-child dyads from diverse racial and ethnic backgrounds to determine the direction and potential causal nature of these associations. These studies should include serially collected biospecimens, standardized workflows that conserve microbial DNA and RNA, and rich data on clinical outcomes and environmental, lifestyle, and genetic risk factors for obesity and diabetes.

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“…This, in turn, has been shown to positively associate with elevated inflammatory markers 2 and again with insulin resistance 3, 4 in non-pregnant populations. Diet composition has recently been shown to associate with serum zonulin concentration, 5 suggesting a new mechanism for how diet may contribute to the onset of inflammation associated metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum zonulin for use as an early predictor for gestational diabetes

et al. 2017

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Diet has an important role in regulating intestinal permeability and subsequently the risk for metabolic disorders. In this observational study, we examined whether serum intestinal permeability marker zonulin, could be used as a predictor for gestational diabetes mellitus (GDM). Serum zonulin concentration was measured in early pregnancy in overweight or obese pregnant women (n=88) at risk for developing GDM. Serum zonulin was associated with higher odds of GDM (adjusted OR for 1 ng ml−1 increase in zonulin: 1.08, 95% CI: 1.02–1.15; P=0.009), diagnosed by a 2-h 75-g oral glucose tolerance test at late pregnancy. The optimal cutoff value was 43.3 ng ml−1, with sensitivity of 88% (95% CI: 71–100%) and specificity of 47% (95% CI: 33–58%). The area under the ROC-curve was 0.67 (95% CI: 0.54–0.81). Our results show an association between increased early-pregnancy serum zonulin concentration and GDM, suggesting zonulin as a possible predictor for GDM.

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Gut Microbiota Richness and Composition and Dietary Intake of Overweight Pregnant Women Are Related to Serum Zonulin Concentration, a Marker for Intestinal Permeability

Cited by 118 publications

References 37 publications

The Maternal Gut Microbiome During Pregnancy

The Maternal Gut Microbiome During Pregnancy

Charting the Maternal and Infant Microbiome: What Is the Role of Diabetes and Obesity in Pregnancy?

Evaluation of serum zonulin for use as an early predictor for gestational diabetes

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