Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex

Xu, Jinchun; Xu, Yi; Xiao, Jie; Bi, Nanxi; Gu, Xiaozhen; Wang, Huili

doi:10.1016/j.celrep.2022.110478

Cited by 20 publications

(11 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, bold individuals would have higher activity level or more aggressive, which required them to have a higher metabolic rate to support their behavior phenotypes, and bold individuals via their personality-dependent behavior and physiological characteristics to influence the gut microbiota composition. One study found that socially dominant rats could be distinguished from subordinates based on their intestinal microbiota: Clostridiaceae, Prevotellaceae, and Bifidobacteriaceae were significantly enriched in dominant rats, which were associated with butyrate production, whereas Veillonellaceae were less represented [ 62 ]. The FMT experiment showed that gut microbiota was the key to maintaining social dominance, and sodium butyrate could enhance the social dominance of mice [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

“…One study found that socially dominant rats could be distinguished from subordinates based on their intestinal microbiota: Clostridiaceae, Prevotellaceae, and Bifidobacteriaceae were significantly enriched in dominant rats, which were associated with butyrate production, whereas Veillonellaceae were less represented [ 62 ]. The FMT experiment showed that gut microbiota was the key to maintaining social dominance, and sodium butyrate could enhance the social dominance of mice [ 62 ]. Another study found that the gut microbiota composition of dogs was based on their body condition [ 63 ], which suggested that the state of the host may determine the composition of the gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

“…Another study found that the gut microbiota composition of dogs was based on their body condition [ 63 ], which suggested that the state of the host may determine the composition of the gut microbiota. As a result, we hypothesized that personality-dependent physiological variation could be the source of their gut microbiota differences; in turn, the gut microbiota could involve and affect host physiology via multiple pathways, and then enhance personality phenotypes via these physiological changes, such as cerebral epigenetic marks [ 64 ], and the butyrate-producing [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Gut Microbiota May Affect Personality in Mongolian Gerbils

Gan

Liu

et al. 2022

Microorganisms

View full text Add to dashboard Cite

The “gut–microbiota–brain axis” reveals that gut microbiota plays a critical role in the orchestrating behavior of the host. However, the correlation between the host personalities and the gut microbiota is still rarely known. To investigate whether the gut microbiota of Mongolian gerbils (Meriones unguiculatus) differs between bold and shy personalities, we compared the gut microbiota of bold and shy gerbils, and then we transplanted the gut microbiota of bold and shy gerbils into middle group gerbils (individuals with less bold and shy personalities). We found a significant overall correlation between host boldness and gut microbiota. Even though there were no significant differences in alpha diversity and beta diversity of gut microbiota between bold and shy gerbils, the Firmicutes/Bacteroidetes phyla and Odoribacter and Blautia genus were higher in bold gerbils, and Escherichia_shigella genus was lower. Furthermore, the fecal microbiota transplantation showed that changes in gut microbiota could not evidently cause the increase or decrease in the gerbil’s boldness score, but it increased the part of boldness behaviors by gavaging the “bold fecal microbiota”. Overall, these data demonstrated that gut microbiota were significantly correlated with the personalities of the hosts, and alteration of microbiota could alter host boldness to a certain extent.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Gut Microbiota May Affect Personality in Mongolian Gerbils

Gan

Liu

et al. 2022

Microorganisms

View full text Add to dashboard Cite

show abstract

“…The gut microbiome is a key regulator for the immune systems and metabolic processes of hosts to maintain body health [ 21 , 22 , 23 , 24 ]. Recent studies have reported that gut microbiota are implicated in the social hierarchy formation of animals [ 25 , 26 , 27 ]. Mice in the same colony with different social dominance status carry characteristic configurations of gut microbiota, while the gut microbiota metabolites are able to influence the establishment of social hierarchy [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have reported that gut microbiota are implicated in the social hierarchy formation of animals [ 25 , 26 , 27 ]. Mice in the same colony with different social dominance status carry characteristic configurations of gut microbiota, while the gut microbiota metabolites are able to influence the establishment of social hierarchy [ 25 ]. Our previous studies identified that the gut microbiome is involved in radiation-induced toxicity and could be employed to combat acute radiation syndrome in mouse models without social dominance hierarchy [ 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Social Hierarchy Dictates Intestinal Radiation Injury in a Gut Microbiota-Dependent Manner

Zeng

Liu

Dong

et al. 2022

IJMS

View full text Add to dashboard Cite

Social hierarchy governs the physiological and biochemical behaviors of animals. Intestinal radiation injuries are common complications connected with radiotherapy. However, it remains unclear whether social hierarchy impacts the development of radiation-induced intestinal toxicity. Dominant mice exhibited more serious intestinal toxicity following total abdominal irradiation compared with their subordinate counterparts, as judged by higher inflammatory status and lower epithelial integrity. Radiation-elicited changes in gut microbiota varied between dominant and subordinate mice, being more overt in mice of higher status. Deletion of gut microbes by using an antibiotic cocktail or restructuring of the gut microecology of dominant mice by using fecal microbiome from their subordinate companions erased the difference in radiogenic intestinal injuries. Lactobacillus murinus and Akkermansia muciniphila were both found to be potential probiotics for use against radiation toxicity in mouse models without social hierarchy. However, only Akkermansia muciniphila showed stable colonization in the digestive tracts of dominant mice, and significantly mitigated their intestinal radiation injuries. Our findings demonstrate that social hierarchy impacts the development of radiation-induced intestinal injuries, in a manner dependent on gut microbiota. The results also suggest that the gut microhabitats of hosts determine the colonization and efficacy of foreign probiotics. Thus, screening suitable microbial preparations based on the gut microecology of patients might be necessary in clinical application.

show abstract