Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review

Knudsen, Julie Kristine; Bundgaard‐Nielsen, Caspar; Hjerrild, Simon; Nielsen, René Ernst; Leutscher, Peter; Sørensen, Susanne

doi:10.1002/brb3.2177

Cited by 63 publications

(67 citation statements)

References 87 publications

(236 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Though our experiments did not assess the molecular mechanism of the antidepressantlike activity of Yacon tuber extract, we guess that it can be at least partially caused by the antioxidant [10,41], anti-inflammatory, and probiotic properties of its main components, particularly fructooligosaccharides, inulin, polyphenols, and tryptophan. It would be in line with new theories of depression, which associate the development of this disease with oxidative stress [50], (neuro)inflammation [51], and disturbances in the gut-microbiotabrain axis [52]. In diabetic rats, Yacon supplementation resulted in a considerable reduction in the hepatic and renal levels of malondialdehyde and activities of superoxide dismutase and catalase.…”

Section: Discussionsupporting

confidence: 66%

Influence of Smallanthus sonchifolius (Yacon) on the Activity of Antidepressant Drugs in Mice

Wośko

Serefko

Szopa

et al. 2021

Life

View full text Add to dashboard Cite

Depression is one of the most common mental disorders in the world that negatively affects the daily functioning of patients. Numerous studies are currently being conducted to examine the antidepressant potential of innovative synthetic compounds and herbal substances. Yacon, Smallantchus sonchifolius, belongs to plants with numerous health-beneficial properties. Yacon-based products are regarded as a functional food. In our study, we attempted to check whether administration of Yacon tuber extract would have an antidepressant effect in the forced swim test (FST) in mice and whether its intake could influence the activity of conventional antidepressant drugs with different mechanisms of action, i.e., imipramine hydrochloride, fluoxetine hydrochloride, and reboxetine mesylate. The spontaneous locomotor activity of the tested mice was also investigated to eliminate any false-positive results. We demonstrated that an intragastric administration of the Yacon tuber extract at a dose of 100 mg/kg induced the antidepressant-like behavior in the FST in mice and that a combined administration of the sub-effective doses of the Yacon extract (50 mg/kg) with imipramine hydrochloride (7.5 mg/kg), fluoxetine hydrochloride (20 mg/kg), or reboxetine mesylate (5 mg/kg) significantly reduced the immobility time of animals in this behavioral test. The obtained results were not affected by the increased locomotor activity of the tested subjects. In conclusion, our findings suggest that Yacon tuber extract is promising as an alternative mood-improving product since it possesses an antidepressant potential and it can acts synergistically with conventional antidepressant drugs.

show abstract

Section: Discussionsupporting

confidence: 66%

Influence of Smallanthus sonchifolius (Yacon) on the Activity of Antidepressant Drugs in Mice

Wośko

Serefko

Szopa

et al. 2021

Life

View full text Add to dashboard Cite

show abstract

“…Faecalibacterium is known as a main component of butyrate-producing bacteria in the gut, and butyrate has been reported to maintain BDNF levels and neurogenesis in the hippocampus, and improve depressive behavior. In the case of Bifidobacterium, several reports have indicated an opposite pattern to that found in [8]. Aizawa et al, for example, reported lower counts of Bifidobacterium and lactobacilli in the gut microbiota of patients with MDD compared with healthy controls [9], results supported by a number of previous studies in animal models [10][11][12].…”

Section: Introductionmentioning

confidence: 87%

“…Alterations in the gut microbiota composition have been investigated in several human studies. Knudsen et al conducted a systematic review of 17 studies analyzing the gut microbiota of MDD patients, and identified an increase in Eggerthella, Atopobium, and Bifidobacterium (all of the Actinobacteria phylum), and a decrease in Faecalibacterium, as common features in such patients [8]. Faecalibacterium is known as a main component of butyrate-producing bacteria in the gut, and butyrate has been reported to maintain BDNF levels and neurogenesis in the hippocampus, and improve depressive behavior.…”

Section: Introductionmentioning

confidence: 99%

How Microbes Affect Depression: Underlying Mechanisms via the Gut–Brain Axis and the Modulating Role of Probiotics

Suda

Matsuda

2022

IJMS

View full text Add to dashboard Cite

Accumulating evidence suggests that the gut microbiome influences the brain functions and psychological state of its host via the gut–brain axis, and gut dysbiosis has been linked to several mental illnesses, including major depressive disorder (MDD). Animal experiments have shown that a depletion of the gut microbiota leads to behavioral changes, and is associated with pathological changes, including abnormal stress response and impaired adult neurogenesis. Short-chain fatty acids such as butyrate are known to contribute to the up-regulation of brain-derived neurotrophic factor (BDNF), and gut dysbiosis causes decreased levels of BDNF, which could affect neuronal development and synaptic plasticity. Increased gut permeability causes an influx of gut microbial components such as lipopolysaccharides, and the resultant systemic inflammation may lead to neuroinflammation in the central nervous system. In light of the fact that gut microbial factors contribute to the initiation and exacerbation of depressive symptoms, this review summarizes the current understanding of the molecular mechanisms involved in MDD onset, and discusses the therapeutic potential of probiotics, including butyrate-producing bacteria, which can mediate the microbiota–gut–brain axis.

show abstract

“… 38 − 40 Clinical studies have shown altered microbiota profiles in the feces of depressive patients. 41 , 42 However, how gut microbiota affects neural functions remains poorly understood, and the detection of fecal host proteins may provide a hint for elucidating the interaction between altered microbiota and host tissues. Thus, we considered that a deep proteome analysis would be suitable for observing changes in host-derived proteins in fecal samples containing abundant bacteria- and food-derived proteins and examined changes in fecal host proteins of mice that received R-SDS using our 10K proteome approach.…”

Section: Resultsmentioning

confidence: 99%

Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry

et al. 2022

View full text Add to dashboard Cite

The evolution of mass spectrometry (MS) and analytical techniques has led to the demand for proteome analysis with high proteome coverage in single-shot measurements. Focus has been placed on data-independent acquisition (DIA)-MS and ion mobility spectrometry as techniques for deep proteome analysis. We aimed to expand the proteome coverage by single-shot measurements using optimizing high-field asymmetric waveform ion mobility spectrometry parameters in DIA-MS. With our established proteome analysis system, more than 10,000 protein groups were identified from HEK293 cell digests within 120 min of MS measurement time. Additionally, we applied our approach to the analysis of host proteins in mouse feces and detected as many as 892 host protein groups (771 upregulated/121 downregulated proteins) in a mouse model of repeated social defeat stress (R-SDS) used in studying depression. Interestingly, 285 proteins elevated by R-SDS were related to mental disorders. The fecal host protein profiling by deep proteome analysis may help us understand mental illness pathologies noninvasively. Thus, our approach will be helpful for an in-depth comparison of protein expression levels for biological and medical research because it enables the analysis of highly proteome coverage in a single-shot measurement.

show abstract

Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review

Cited by 63 publications

References 87 publications

Influence of Smallanthus sonchifolius (Yacon) on the Activity of Antidepressant Drugs in Mice

Influence of Smallanthus sonchifolius (Yacon) on the Activity of Antidepressant Drugs in Mice

How Microbes Affect Depression: Underlying Mechanisms via the Gut–Brain Axis and the Modulating Role of Probiotics

Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry

Contact Info

Product

Resources

About