Gut mycobiome as a promising preventive and therapeutic target for metabolic disorders

Zheng, Liaoyuan

doi:10.1016/j.metop.2022.100168

Cited by 7 publications

(8 citation statements)

References 20 publications

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“…These fungi are typically harmless when present in small amounts, but when they grow out of control, they can have harmful effects on human health. For example, some fungi in the gut produce enzymes that help to break down food, while others may have a role in regulating the immune system (55). Some evidence suggests that the mycobiome may be related to CVD, a condition affecting the heart and blood vessels.…”

Section: Fungi Microbiotamentioning

confidence: 99%

The potential links between human gut microbiota and cardiovascular health and disease - is there a gut-cardiovascular axis?

Almeida,

Gonçalves-Nobre,

Alpuim Costa

et al. 2023

Front. Gastroenterol.

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The gut-heart axis is an emerging concept highlighting the crucial link between gut microbiota and cardiovascular diseases (CVDs). Recent studies have demonstrated that gut microbiota is pivotal in regulating host metabolism, inflammation, and immune function, critical drivers of CVD pathophysiology. Despite a strong link between gut microbiota and CVDs, this ecosystem’s complexity still needs to be fully understood. The short-chain fatty acids, trimethylamine N-oxide, bile acids, and polyamines are directly or indirectly involved in the development and prognosis of CVDs. This review explores the relationship between gut microbiota metabolites and CVDs, focusing on atherosclerosis and hypertension, and analyzes personalized microbiota-based modulation interventions, such as physical activity, diet, probiotics, prebiotics, and fecal microbiota transplantation, as a promising strategy for CVD prevention and treatment.

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Section: Fungi Microbiotamentioning

confidence: 99%

The potential links between human gut microbiota and cardiovascular health and disease - is there a gut-cardiovascular axis?

Almeida,

Gonçalves-Nobre,

Alpuim Costa

et al. 2023

Front. Gastroenterol.

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“…For instance, Saccharomycetales spp. interacts with intestinal bacteria and are positively related to SCFA producers to influence insulin sensitivity (Dalamaga et al, 2022 ). These results suggest that comprehensive cross‐boundary analyses may broaden our horizons and help us in identifying new prevention and treatment targets for metabolic disorders.…”

Section: Intestinal Microbes Involved In Lipid Metabolism In the Hostmentioning

confidence: 99%

The intestinal microbiome associated with lipid metabolism and obesity in humans and animals

Jian

Zeng

et al. 2022

Journal of Applied Microbiology

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Intestinal microbiota is considered to play an integral role in maintaining health of host by modulating several physiological functions including nutrition, metabolism and immunity. Accumulated data from human and animal studies indicate that intestinal microbes can affect lipid metabolism in host through various direct and indirect biological mechanisms. These mechanisms include the production of various signalling molecules by the intestinal microbiome, which exert a strong effect on lipid metabolism, bile secretion in the liver, reverse transport of cholesterol and energy expenditure and insulin sensitivity in peripheral tissues. This review discusses the findings of recent studies suggesting an emerging role of intestinal microbiota and its metabolites in regulating lipid metabolism and the association of intestinal microbiota with obesity. Additionally, we discuss the controversies and challenges in this research area. However, intestinal micro-organisms are also affected by some external factors, which in turn influence the regulation of microbial lipid metabolism. Therefore, we also discuss the effects of probiotics, prebiotics, diet structure, exercise and other factors on intestinal microbiological changes and lipid metabolism regulation. K E Y W O R D Sintestinal microbiota, human and animal, lipid metabolism, short-chain fatty acid, exercise and diet, metabolic disorder, obesityThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Currently, the rising incidence of NAFLD with its different phenotypes has rendered imperative its better understanding and effective treatment [ [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] ]. There is agreement that a balanced gut mycobiome contributes to the maintenance of host immune homeostasis [ 27 , 28 ]. More large-scale, longer-term, longitudinal studies are required to determine whether changes that occur in the bacteriome and mycobiome are causal or consequent of NAFLD progression.…”

mentioning

confidence: 99%

“…Furthermore, specific metabolic pathways and mediators, an intact gut barrier and bacterial-fungal interactions may play an important role in this process, as summarized in Fig. 1 [ 27 , 28 ]. The majority of studies has focused on descriptive findings of the gut microbiome; however, joint analyses on gut mycobiome with other advanced tools, such as metagenomics and metabolomics, are needed to provide new perspectives into the pathophysiology of NAFLD [ 1 ].…”

mentioning

confidence: 99%

Gut mycobiome as a promising preventive and therapeutic target for metabolic disorders

Cited by 7 publications

References 20 publications

The potential links between human gut microbiota and cardiovascular health and disease - is there a gut-cardiovascular axis?

The potential links between human gut microbiota and cardiovascular health and disease - is there a gut-cardiovascular axis?

The intestinal microbiome associated with lipid metabolism and obesity in humans and animals

Could gut mycobiome play a role in NAFLD pathogenesis? Insights and therapeutic perspectives

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