Gut Permeability, Its Interaction with Gut Microflora and Effects on Metabolic Health are Mediated by the Lymphatics System, Liver and Bile Acid

Tran, Cuong; Grice, Desma M.; Wade, Ben; Kerr, Caroline A; Bauer, Denis C.; Li, Dongmei; Hannan, Garry N.

doi:10.2217/fmb.15.54

Cited by 41 publications

(38 citation statements)

References 125 publications

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“…Moreover, there was no significant difference in the value of F/B between T2DM participants and non‐T2DM controls (data not shown). It is well known that the blood microbiome is derived primarily from the gut microbiome as a result of bacterial translocation . However, as previously reported, the blood and gut microbiomes differ significantly from each other, indicating that the intestinal barrier, immune cells, and liver might play a role of filtering and affecting the bacterial translocation .…”

Section: Discussionmentioning

confidence: 62%

Association between blood microbiome and type 2 diabetes mellitus: A nested case‐control study

Qiu

Zhou²,

Yang

et al. 2019

Clinical Laboratory Analysis

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BackgroundAlthough recent studies have indicated that gut microbiome dysbiosis was significantly associated with the onset of type 2 diabetes mellitus (T2DM), information on the role of blood microbiome in T2DM development is scarce.MethodsFifty incident T2DM cases and 100 matched non‐T2DM controls were selected from a prospective cohort study of “135.” The composition of the blood microbiome was characterized using bacterial 16S ribosomal RNA (16S rRNA) gene sequencing from pre‐diagnostic blood sample. The amplicons were normalized, pooled, and sequenced on the Illumina MiSeq instrument using a MiSeq Reagent Kit PE300 v3 kit.ResultsTotally, 3 000 391 and 6 244 227 high‐quality sequences were obtained from T2DM patients and non‐T2DM controls, respectively. The mean diversity of the blood microbiome (Simpson, Chao1 and Shannon indices) was not different between two groups at baseline. At genus level, the Aquabacterium, Xanthomonas, and Pseudonocardia were presented with lower abundance, while Actinotalea, Alishewanella, Sediminibacterium, and Pseudoclavibacter were presented with higher abundance among T2DM cases compared to those in non‐T2DM controls. As the results shown, participants carried the genus Bacteroides in blood were significantly associated with a decreased risk for T2DM development, with 74% vs 88% (adjusted OR: 0.367, 95% CI: 0.151‐0.894). However, participants carried the genus Sediminibacterium have an increased risk for T2DM, with adjusted OR (95% CI) being 14.098 (1.358, 146.330).ConclusionsBlood microbiome may play an etiology role in the development of T2DM. These findings would be useful to develop microbiota‐based strategies for T2DM prevention and control.

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Section: Discussionmentioning

confidence: 62%

Association between blood microbiome and type 2 diabetes mellitus: A nested case‐control study

Qiu

Zhou²,

Yang

et al. 2019

Clinical Laboratory Analysis

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“…4C). Given that intestinal dysbiosis in HFD-fed animals may affect gut permeability and subsequently lead to systematic inflammation and IR(Tran et al, 2015), we next examined the expression of the tight junction components including occludin, zonula occludens-1 (ZO-1) and claudin-1 in the intestine. Expression of these proteins was significantly reduced in H. pylori -infected HFD groups, indicating an aberration of gut barrier function (Fig.…”

Section: Resultsmentioning

confidence: 99%

Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice

Yang

Cheng

et al. 2016

EBioMedicine

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Emerging evidence suggests that Helicobacter pylori infection is associated with insulin resistance (IR) yet the underlying mechanisms are still obscure. The vital role of gut microbiota in triggering IR has been increasingly reported, however, no study has explored the correlation of gut microbiota and H. pylori-associated IR. Using H. pylori-infected mice model fed different diet structures, we demonstrated that H. pylori infection significantly aggravated high-fat diet (HFD)-induced metabolic disorders at the early stage, the extent of which was close to the effect of long-term HFD. Interestingly, we observed dynamic alterations in gut microbiota that were consistent with the changes in the metabolic phenotype induced by H. pylori and HFD. There may be an interaction among H. pylori, diet and gut microbiota, which dysregulates the host metabolic homeostasis, and treatment of H. pylori may be beneficial to the patients with impaired glucose tolerance in addition to diet control.

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“…[16, 17] Gut barrier impairment may lead to alteration of gut microflora, in turn, gut microbiota can influence the integrity of the intestinal epithelium as well as the gut barrier function. [18]…”

Section: Introductionmentioning

confidence: 99%

The changes of gut microbiota after acute myocardial infarction in rats

Chen

et al. 2017

PLoS ONE

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Recent studies suggested that gut microbiota was involved in the development of coronary artery disease. However, the changes of gut microbiota following acute myocardial infarction (AMI) remain unknown. In this study, a total of 66 male Wistar rats were randomly divided into control, AMI and SHAM groups. The controls (n = 6) were sacrificed after anesthesia. The AMI model was built by ligation of left anterior descending coronary artery. The rats of AMI and SHAM groups were sacrificed at 12 h, 1 d, 3 d, 7 d and 14 d post-operation respectively. Gut microbiota was analyzed by 16S rDNA high throughput sequencing. The gut barrier injuries were evaluated through histopathology, transmission electron microscope and immunohistochemical staining. The richness of gut microbiota was significantly higher in AMI group than SHAM group at 7 d after AMI (P<0.05). Principal coordinate analysis with unweighted UniFrac distances revealed microbial differences between AMI and SHAM groups at 7 d. The gut barrier impairment was also the most significant at 7 d post-AMI. We further identified the differences of microorganisms between AMI and SHAM group at 7 d. The abundance of Synergistetes phylum, Spirochaetes phylum, Lachnospiraceae family, Syntrophomonadaceae family and Tissierella Soehngenia genus was higher in AMI group compared with SHAM group at 7 d post-operation (q<0.05). Our study showed the changes of gut microbiota at day 7 post AMI which was paralleled with intestinal barrier impairment. We also identified the microbial organisms that contribute most.

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Gut Permeability, Its Interaction with Gut Microflora and Effects on Metabolic Health are Mediated by the Lymphatics System, Liver and Bile Acid

Cited by 41 publications

References 125 publications

Association between blood microbiome and type 2 diabetes mellitus: A nested case‐control study

Association between blood microbiome and type 2 diabetes mellitus: A nested case‐control study

Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice

The changes of gut microbiota after acute myocardial infarction in rats

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