Gut stem cells: Interplay with immune system, microbiota, and aging

Marotta, Francesco; Balakrishnan, Baskar; Yazdani, Amirnaser; Ayala, Antonio; He, Fang; Cangemi, Roberto

doi:10.1016/b978-0-12-820071-1.00017-7

Cited by 1 publication

(2 citation statements)

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“…Recently, a specific bioactive fraction of Rhodiola complexed with a marine lipoprotein extract from Trachurus sp. has been shown to markedly stimulate cell proliferation rate in cells under oxidative stress, imitating what has been observed in the aging process . This phytomarine complex with notable senolytic activity also considerably upregulates the vitagenes SIRT-1 and MMP2 and might offer an innovative approach to avoid oxidative stress damage and prevent cell aging …”

Section: Antiaging Drugsmentioning

confidence: 72%

“…has been shown to markedly stimulate cell proliferation rate in cells under oxidative stress, imitating what has been observed in the aging process. 328 This phytomarine complex with notable senolytic activity also considerably upregulates the vitagenes SIRT-1 and MMP2 328 and might offer an innovative approach to avoid oxidative stress damage and prevent cell aging. 329 The efficacy of the suggested senolytic drugs has been demonstrated in model organisms for age-and cellular senescence-associated physical disabilities, insulin resistance, cognitive decline, osteoporosis, osteoarthritis, and cancers.…”

Section: Antiaging Drugsmentioning

confidence: 99%

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Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

Tenchov,

Sasso,

Wang

et al. 2024

ACS Chem. Neurosci.

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Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collection to analyze the publication landscape of recent research related to antiaging strategies and treatments. We review the recent advances and delineate trends in research headway of antiaging knowledge and practice across time, geography, and development pipelines. We further assess the state-of-theart antiaging approaches and explore their correlations with age-related diseases. The landscape of antiaging drugs has been outlined and explored. Well-recognized and novel, currently evaluated antiaging agents have also been summarized. Finally, we review clinical applications of antiaging products with their development pipelines. The objective of this review is to summarize current knowledge on preventive strategies and treatment remedies in the field of aging, to outline challenges and evaluate growth opportunities, in order to further efforts to solve the problems that remain.

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Section: Antiaging Drugsmentioning

confidence: 72%