GWAS advancements to investigate disease associations and biological mechanisms
Oluwaferanmi Omidiran,
Aashna Patel,
Sarah Usman
et al.
Abstract:Genome‐wide association studies (GWAS) have been instrumental in elucidating the genetic architecture of various traits and diseases. Despite the success of GWAS, inherent limitations such as identifying rare and ultra‐rare variants, the potential for spurious associations and pinpointing causative agents can undermine diagnostic capabilities. This review provides an overview of GWAS and highlights recent advances in genetics that employ a range of methodologies, including whole‐genome sequencing (WGS), Mendel… Show more
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