2023
DOI: 10.3389/fgene.2022.972196
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GWAS of depression in 4,520 individuals from the Russian population highlights the role of MAGI2 (S-SCAM) in the gut-brain axis

Abstract: We present the results of the depression Genome-wide association studies study performed on a cohort of Russian-descent individuals, which identified a novel association at chromosome 7q21 locus. Gene prioritization analysis based on already known depression risk genes indicated MAGI2 (S-SCAM) as the most probable gene from the locus and potential susceptibility gene for the disease. Brain and gut expression patterns were the main features highlighting functional relatedness of MAGI2 to the previously known de… Show more

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Cited by 8 publications
(2 citation statements)
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“…First, PGS was calculated on the basis of a limited number of examined genetic variants, thus resulting in a small value of the proportion of variance explained by PGS. It should also be mentioned that to date, GWAS of depression conducted in a cohort of Russian descent was carried out [49]; however, summary statistics from this study remain publicly unavailable. Therefore, for the sensitivity analysis, we calculated PGS based on effect estimates from GWAS of depression/neuroticism of Western Europeans.…”
Section: Discussionmentioning
confidence: 99%
“…First, PGS was calculated on the basis of a limited number of examined genetic variants, thus resulting in a small value of the proportion of variance explained by PGS. It should also be mentioned that to date, GWAS of depression conducted in a cohort of Russian descent was carried out [49]; however, summary statistics from this study remain publicly unavailable. Therefore, for the sensitivity analysis, we calculated PGS based on effect estimates from GWAS of depression/neuroticism of Western Europeans.…”
Section: Discussionmentioning
confidence: 99%
“…Проведенный биоинформатический анализ показал, что экспрессия гена MAGI-2 наиболее высока в отдельных структурах мозга, а также в кишечнике. Менделевский рандомизационный анализ подтвердил причинно-следственные связи воспалительных заболеваний кишечника и количественного фенотипа депрессии на основе HADS-D [47].…”
Section: Introductionunclassified