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Charlwood, J. D.; Pinto, João; Sousa, Carla A.; Ferreira, C.; Petrarca, V.; Rosário, Virgı́lio do

doi:10.1186/1475-2875-2-9

Cited by 42 publications

(24 citation statements)

References 30 publications

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“…The result for body size is in line with several studies [7,51,54,55,88,154] and thus the model captures some of the aspects related to higher survival among larger individuals. Note that we have not accounted for the higher metabolism in large mosquitoes [71], which might reduce survival under warm and dry conditions.…”

Section: Discussionsupporting

confidence: 89%

A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. I. Model description and sensitivity analysis

Lunde

Korecha

Loha

et al. 2013

Malar J

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BackgroundMost of the current biophysical models designed to address the large-scale distribution of malaria assume that transmission of the disease is independent of the vector involved. Another common assumption in these type of model is that the mortality rate of mosquitoes is constant over their life span and that their dispersion is negligible. Mosquito models are important in the prediction of malaria and hence there is a need for a realistic representation of the vectors involved.ResultsWe construct a biophysical model including two competing species, Anopheles gambiae s.s. and Anopheles arabiensis. Sensitivity analysis highlight the importance of relative humidity and mosquito size, the initial conditions and dispersion, and a rarely used parameter, the probability of finding blood. We also show that the assumption of exponential mortality of adult mosquitoes does not match the observed data, and suggest that an age dimension can overcome this problem.ConclusionsThis study highlights some of the assumptions commonly used when constructing mosquito-malaria models and presents a realistic model of An. gambiae s.s. and An. arabiensis and their interaction. This new mosquito model, OMaWa, can improve our understanding of the dynamics of these vectors, which in turn can be used to understand the dynamics of malaria.

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Section: Discussionsupporting

confidence: 89%

A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. I. Model description and sensitivity analysis

Lunde

Korecha

Loha

et al. 2013

Malar J

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“…In this generally monoandrous species, virgin females enter a swarm of males, mate, and leave the swarm while still in copula [28],[29]. It is unlikely that a female would re-enter the swarm (and indeed double plugs are almost never observed in the field [12],[30]), and therefore there would be very little selective pressure for a plug that acts as a physical block.…”

Section: Discussionmentioning

confidence: 99%

Transglutaminase-Mediated Semen Coagulation Controls Sperm Storage in the Malaria Mosquito

et al. 2009

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“…Only female adult mosquitoes are modeled although male eggs and larvae remain to appropriately account for density dependence during the larval stage. Upon emerging as adults, females rest outdoors before either mating or feeding, and the 50% who feed as virgins [56] but do not encounter or are not affected by DBH, subsequently mate. We assume an excess of males such that every female can successfully mate.…”

Section: Methodsmentioning

confidence: 99%

Disrupting Mosquito Reproduction and Parasite Development for Malaria Control

et al. 2016

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The control of mosquito populations with insecticide treated bed nets and indoor residual sprays remains the cornerstone of malaria reduction and elimination programs. In light of widespread insecticide resistance in mosquitoes, however, alternative strategies for reducing transmission by the mosquito vector are urgently needed, including the identification of safe compounds that affect vectorial capacity via mechanisms that differ from fast-acting insecticides. Here, we show that compounds targeting steroid hormone signaling disrupt multiple biological processes that are key to the ability of mosquitoes to transmit malaria. When an agonist of the steroid hormone 20-hydroxyecdysone (20E) is applied to Anopheles gambiae females, which are the dominant malaria mosquito vector in Sub Saharan Africa, it substantially shortens lifespan, prevents insemination and egg production, and significantly blocks Plasmodium falciparum development, three components that are crucial to malaria transmission. Modeling the impact of these effects on Anopheles population dynamics and Plasmodium transmission predicts that disrupting steroid hormone signaling using 20E agonists would affect malaria transmission to a similar extent as insecticides. Manipulating 20E pathways therefore provides a powerful new approach to tackle malaria transmission by the mosquito vector, particularly in areas affected by the spread of insecticide resistance.

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Untitled

Cited by 42 publications

References 30 publications

A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. I. Model description and sensitivity analysis

A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. I. Model description and sensitivity analysis

Transglutaminase-Mediated Semen Coagulation Controls Sperm Storage in the Malaria Mosquito

Disrupting Mosquito Reproduction and Parasite Development for Malaria Control

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