The current review focuses on a detailed comprehensive role of Gymnema sylvestre (GS) and other herbs for their Ayurvedic impact in controlling blood sugar by releasing insulin from the pancreas in diabetic Type 2. G. sylvestre (GS) supplementation has also been seen to leave an impact on various cardiovascular risk factors and improves the lipid profile, blood pressure, anthropometric indices, and control of glycemia. Additionally, extracts of Gymnema have been shown to have an inhibitory impact on triglyceride accumulation in muscles and the liver, while reducing the buildup of fatty acids in the bloodstream, thus also reducing HB1C parameters. In the current review, we have also discussed information about Gymnemic acid structure isolation their sources, their clinical effects in diabetic control in Type 1 and Type 2, and clinical effects over the humans and mice signalling as immunomodulators.