Gynaecological and obstetrical bleeding in women with factor XI deficiency – a systematic review

Abstract

Women with FXI deficiency have a clearly increased risk of HMB, and of bleeding complications after miscarriage, TOP and delivery. No high quality data are available regarding prophylactic treatment.

Women prefer proactive support from providers for treatment of heavy menstrual bleeding: A qualitative study in adult women with moderate or severe Von Willebrand disease

“…Heavy menstrual bleeding (HMB) is considered an important health problem, specifically in women with Von Willebrand disease (VWD) . In 10%‐20% of women presenting at the gynaecologist with HMB without gynaecological abnormalities, a coagulation disorders were diagnosed . In several studies, over 74%‐92% of women with VWD report HMB .…”

“…1In 10%-20% of women presenting at the gynaecologist with HMB without gynaecological abnormalities, a coagulation disorders were diagnosed. 2,3 In several studies, over 74%-92% of women with VWD report HMB. 1,2 According to the Von Willebrand in the Netherlands study (WiN study), in 25% of all women with moderate-to-severe VWD of 40s or older, a hysterectomy for HMB had been performed, Objective: To explore key factors for successful support in women with moderate or severe Von Willebrand disease (VWD) who are faced with heavy menstrual bleeding (HMB) and surgery.…”

Preventing deaths due to haemorrhage

“…[ 22 ] The risk appears to be reduced with prophylaxis, but no evidence from interventional studies is available.…”

Congenital and acquired bleeding disorders in pregnancy

“…FXI deficiency may be associated with increased risk of miscarriage and postpartum bleeding but high-quality data regarding prophylaxis are not available. 12 Prophylactic replacement for women with fibrinogen and FXIII deficiency may increase the chance for successful pregnancy outcome. Similarly, prophylaxis for deficiencies of FX, FV, and FVII are not well characterized, but may be indicated in women with a history of bleeding complications.…”