Gynaecological cancers in Umbria (Italy): trends of incidence, mortality and survival, 1978–1998

Minelli, Liliana; Stracci, Fabrizio; Prandini, S; Moffa, Igino Fusco; Rosa, Francesco La

doi:10.1016/j.ejogrb.2003.11.026

Cited by 17 publications

(13 citation statements)

References 26 publications

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“…Cervical cancer mortality has been decreasing in most developed countries, possibly as a result of early diagnosis and improved treatments [12,21,22,23]. Two causes likely explain the majority of the trend of decreasing cervical cancer mortality that we found in the four East Asian regions.…”

Section: Discussionmentioning

confidence: 88%

Trends in gynecologic cancer mortality in East Asian regions

et al. 2014

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ObjectiveTo evaluate uterine and ovarian cancer mortality trends in East Asian countries.MethodsFor three Asian countries and one region (Japan, Korea, Singapore, and Hong Kong), we extracted number of deaths for each year from the World Health Organization (WHO) mortality database, focusing on women ≥20 years old. The WHO population data were used to estimate person-years at risk for women. The annual age-standardized, truncated rates were evaluated for four age groups. We also compared age-specific mortality rates during three calendar periods (1979 to 1988, 1989 to 1998, and 1999 to 2010). Joinpoint regression was used to determine secular trends in mortality. To obtain cervical and uterine corpus cancer mortality rates in Korea, we re-allocated the cases with uterine cancer of unspecified subsite according to the proportion in the National Cancer Incidence Databases.ResultsOverall, uterine cancer mortality has decreased in each of the Asian regions. In Korea, corrected cervical cancer mortality has declined since 1993, at an annual percentage change (APC) of -4.8% (95% confidence interval [CI], -5.3 to -4.4). On the other hand, corrected uterine corpus cancer mortality has abruptly increased since 1995 (APC, 6.7; 95% CI, 5.4 to 8.0). Ovarian cancer mortality was stable, except in Korea, where mortality rates steadily increased at an APC of 6.2% (95% CI, 3.4 to 9.0) during 1995 to 2000, and subsequently stabilized.ConclusionAlthough uterine cancer mortality rates are declining in East Asia, additional effort is warranted to reduce the burden of gynecologic cancer in the future, through the implementation of early detection programs and the use of optimal therapeutic strategies.

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Section: Discussionmentioning

confidence: 88%

Trends in gynecologic cancer mortality in East Asian regions

et al. 2014

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“…[1][2][3] Established prognostic factors in endometrial carcinoma are histologic grade, depth of myometrial invasion and extrauterine spread, including retroperitoneal lymph node metastases. 4 Surgical staging is recommended to determine the appropriate treatment for individual patients because these prognostic factors cannot be assessed preoperatively.…”

Section: Introductionmentioning

confidence: 99%

pRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor grade

Sanseverino¹,

Santopietro²,

Torricelli³

et al. 2006

Cancer Biology & Therapy

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Purpose: Endometrial cancer is the most common gynecologic malignancy. Established prognostic factors are histologic grade, depth of myometrial invasion, and extrauterine spread including retroperitoneal lymph node metastases.Tumorigenesis is a multistep process involving different genetic changes resulting in uncontrolled cellular proliferation, inhibition of apoptosis, and enhanced vascular proliferation among other events. Angiogenesis, the formation of new blood vessels from a preexisting vascular network, is necessary for invasive tumor growth and metastasis and constitutes an important point in the control of cancer progression. The pathogenesis of the angiogenetic phenotype may involve the inactivation of different tumor suppressor genes.Experimental design: We investigated the relationship between the expression levels of VEGF and the retinoblastoma family member pRb2/p130 in endometrial carcinoma in relation to histopathologic tumor grade in a cohort of 50 patients.Results: We found that VEGF and pRB2/p130 expression were inversely correlated. Additionally, high grade tumors presented a significantly lower number of cells expressing pRb2/p130 when compared to low grade tumors. A significant positive correlation was found, by means of the Spearman coefficient, between VEGF expression and binary grading (0.450, p-value < 0.005) which is an architectural grading system that uses low-magnification assessment of amount of solid growth, pattern of invasion, and presence of necrosis to divide endometrioid carcinomas into low-and high-grade tumors. Additionally, we also found a negative correlation between pRb2/p130 expression levels and binary grading (-0.595, p-value < 0.005). Interestingly, we also found that VEGF and pRb2/p130 expression levels were not related to staging (p-value > 0.005).Conclusions: These results open up a new perspective including novel markers that, combined together, may be useful in patient screening for endometrial cancer aggressiveness.

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“…Clearly the diffusion of Pap smear testing for cervix cancer may have led to some improvement in stage at diagnosis but it mostly reduced cancer incidence, by removing premalignant lesions before progression [5]. …”

Section: Discussionmentioning

confidence: 99%

“…The relatively low survival from cervix cancer is based on few invasive cancers (about 40 per year), arising in somewhat older women (i.e. they are probably more aggressive cancers diagnosed in women non participating in pap screening) [5]. Ovarian cancer mortality rates showed a very high variability; an improvement in diagnostic definition of abdominal cancers is likely to contribute to the increasing trend observed from 1985 onward.…”

Section: Discussionmentioning

confidence: 99%

“…Regional health structures, including two main oncology centres (Perugia and Terni), are easy to reach by all residents Regional Population screening interventions were introduced since 1998 for the prevention of breast and cervical cancer [5,6]; moreover free offering of pap smear tests for cervix cancer preceded by many years population screening. Opportunistic screening activities are likely to be diffused to some extent for skin melanoma, prostate cancer, and large bowel cancer.…”

Section: Introductionmentioning

confidence: 99%

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Cancer mortality trends in the Umbria region of Italy 1978–2004: a joinpoint regression analysis

Stracci

Canosa²,

Minelli

et al. 2007

BMC Cancer

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Background: The aim of the present paper was to analyse cancer mortality in the Umbria region, from 1978 to 2004. Mortality trends depend on a number of factors including exposures, health system interventions, and possibly artefact (e.g. classification change, variations of data completeness). Descriptive data on mortality only allow for generation of hypotheses to explain observed trends. Some clues on the respective role of possible mortality determinants may be found comparing mortality with incidence and survival data.

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Gynaecological cancers in Umbria (Italy): trends of incidence, mortality and survival, 1978–1998

Cited by 17 publications

References 26 publications

Trends in gynecologic cancer mortality in East Asian regions

Trends in gynecologic cancer mortality in East Asian regions

pRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor grade

Cancer mortality trends in the Umbria region of Italy 1978–2004: a joinpoint regression analysis

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