Gynaecological follow-up for women of reproductive age with multiple sclerosis: The GYNESEP study

Renaud, Juliette; Buissonnière, Pauline; Dulau, Cécile; Deloire, Mathilde; Hontarrede, Florian; Montcuquet, Alexis; Chansel-Debordeaux, Lucie; Hocké, Claude; Ouallet, Jean-Christophe; Ruet, Aurélie; Bernard, Valérie

doi:10.1016/j.msard.2024.105448

Multiple Sclerosis and Related Disorders

2024

DOI: 10.1016/j.msard.2024.105448

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Gynaecological follow-up for women of reproductive age with multiple sclerosis: The GYNESEP study

Juliette Renaud,

Pauline Buissonnière,

Cécile Dulau

et al.

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2024

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Pregnancy and reproductive health in women with multiple sclerosis: an update

Houtchens

2024

Current Opinion in Neurology

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Purpose of the review Multiple sclerosis (MS) is a chronic immune-mediated, inflammatory, neuro-degenerative disease of the central nervous system, prevalent in women of reproductive age. Today, many women want to start a family after MS diagnosis. There are over 20 treatments for MS, and safely navigating family planning is important. We review updated information on family planning, preconception, and peri-partum considerations, and reproductive concerns in special populations with MS. Recent findings There are no MS-related restrictions on any available and appropriate contraceptive method in women with MS. The question of MS and pregnancy outcomes following assisted reproduction, remains somewhat unsettled. In many studies, no elevated relapse risk is confirmed regardless of the type of fertility treatment. MRI status may offer better assessment of postpartum disease stability than relapse rate alone. Ongoing effective MS treatments during fertility assistance and before pregnancy, can further reduce the relapse risk. B-cell depleting therapies are emerging as safe and effective treatments for peripartum MS patients. Summary Patients with MS should receive accurate support and counseling related to their reproductive options. The general outlook on pregnancy and MS remains positive. The ever-increasing therapeutic complexity of MS calls for ongoing education and updated guidance for neuroimmunology and obstetrics healthcare providers.

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Pregnancy and reproductive health in women with multiple sclerosis: an update

Houtchens

2024

Current Opinion in Neurology

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Gynaecological follow-up for women of reproductive age with multiple sclerosis: The GYNESEP study

Cited by 1 publication

References 21 publications

Pregnancy and reproductive health in women with multiple sclerosis: an update

Pregnancy and reproductive health in women with multiple sclerosis: an update

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