Gynaecomastia in a patient with von Recklinghausen's disease (neurofibromatosis type 1)

Intranodal Neurofibroma: A Case Report and Literature Review

“…In total, there were 5 reported cases, 2 of which were plexiform neurofibroma, 1,2 one a localized neurofibroma that gave rise to an adjacent malignant peripheral nerve sheath tumor (MPNST), 3 and 2 with limited descriptions. 4,5…”

“…2 (3) A 30-year-old man who, diagnosed at age 19 with NF1, presented with gynecomastia, back and leg pain, and diarrhea, was found to have mediastinal lymph node neurofibromas on biopsy. 5 (4) An image included in Enzinger and Weiss's Soft Tissue Tumors is described as, "Plexiform neurofibroma involving the nerve and extending into the hilum of the lymph node. Apparent lymph node involvement does not indicate malignancy, but simply reflects diffuseness of the process."…”

“…2 (3) A 30-year-old man who, diagnosed at age 19 with NF1, presented with gynecomastia, back and leg pain, and diarrhea, was found to have mediastinal lymph node neurofibromas on biopsy. 5 (4) An image included in Enzinger and Weiss's Soft Tissue Tumors is described as, “Plexiform neurofibroma involving the nerve and extending into the hilum of the lymph node. Apparent lymph node involvement does not indicate malignancy, but simply reflects diffuseness of the process.” 11 (5) A 16-year-old woman, diagnosed in infancy with neurofibromatosis, had clinically enlarged palpable inguinal lymph nodes, which when excised revealed neurofibroma encasing the nodes and infiltrating them via their hila.…”