Gynura Procumbens: Review of Biological Activities and Their Possible Mechanisms

Pestrenin, L.D.; Kurtsev, Boris V.; Gulyaeva, I. L.; Булатова, И. А.; Мифтахова, А. М.

doi:10.17513/spno.29863

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Джинура Прокумбенс носит официальное международное название Gynura Procumbens, растение из сложноцветущего семейства астровых содержит клетчатку, растительный белок, каратиноиды, флавоноиды, алкалоиды и эфирные масла, оказывающие лечебно-профилактические эффекты, прежде всего, за счет расщепления до мономерных соединений. В ряде исследований было найдено положительное влияние β-ситостеринов при метаболическом синдроме у пациентов с ожирением [9][10][11][12][13]. По данным литературы экстракт из стеблей ДП снижает уровень ферментов и накопление липидов в печеночной ткани [14].…”

Section: Introductionunclassified

Experimental study of the hepatoprotective effect of the aqueous extract of Jinura Procumbens leaves on the model of fructose-induced non-alcoholic liver steatosis

Gulyaeva

Shevlyukova

Булатова

et al. 2022

jour

View full text Add to dashboard Cite

The aim. To study the hepatoprotective effect of the aqueous extract of the leaves of Gynura Procumbens (GP) on an experimental model of fructose-induced non-alcoholic liver steatosis in laboratory animals. Materials and methods. The experimental study was conducted for 30 days on 25 non-inbred sexually mature white male rats aged 8-9 months, weighing 400-530 g., which comprised 3 groups: “Control” (received a full-fledged balanced standard granular feed), “fructose-induced steatosis” (feeding was carried out similarly to animals of the first group using a 15% solution of fructose as drinking water) and “Steatosis + GP” (simulated liver steatosis and simultaneously daily intragastric daily administration of GP leaf extract was performed. Laboratory parameters (transaminases, glucose and lipid spectrum) in blood serum, biometric indicators (animal mass, liver mass and mass coefficient) and histological examination of the liver were studied in all animals according to the conclusion from the experiment. Results. The course of fructose-induced liver steatosis in experimental animals is accompanied by lipid spectrum disorders, hepatomegaly without the formation of general obesity and morphological changes in liver tissue in the form of fatty degeneration without signs of inflammation and fibrosis. Conclusion: The course intragastric administration of an aqueous extract of GP leaves to experimental animals with steatosis does not significantly affect the lipid spectrum, but prevents the formation of hepatomegaly and morphological changes characteristic of steatosis in liver tissue.

show abstract