Gypenoside Pretreatment Alleviates the Cerebral Ischemia Injury via Inhibiting the Microglia-Mediated Neuroinflammation

Xia, Xue; Chen, Jiahao; Ren, Haiyuan; Zhou, Chang; Zhang, Qingli; Cheng, Haoyang; Wang, Xiaojing

doi:10.1007/s12035-023-03624-0

Mol Neurobiol

2023

DOI: 10.1007/s12035-023-03624-0

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Gypenoside Pretreatment Alleviates the Cerebral Ischemia Injury via Inhibiting the Microglia-Mediated Neuroinflammation

Xue Xia,

Jiahao Chen,

Haiyuan Ren

et al.

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2024

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Cited by 3 publications

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Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells

Lu,

Chen,

Wen

2024

Biomedicine & Pharmacotherapy

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Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells

Lu,

Chen,

Wen

2024

Biomedicine & Pharmacotherapy

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Buyang Huanwu Decoction promotes neurovascular remodeling by modulating astrocyte and microglia polarization in ischemic stroke rats

Li,

Lin

et al. 2024

Journal of Ethnopharmacology

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Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Zhang,

Xu,

et al. 2024

Front. Pharmacol.

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Ischemic stroke is a prevalent clinical condition affecting the central nervous system, characterized by a high mortality and disability rate. Its incidence is progressively rising, particularly among younger individuals, posing a significant threat to human well-being. The activation and polarization of microglia, leading to pro-inflammatory and anti-inflammatory responses, are widely recognized as pivotal factors in the pathogenesis of cerebral ischemia and reperfusion injury. Traditional Chinese herbal medicines (TCHMs) boasts a rich historical background, notable efficacy, and minimal adverse effects. It exerts its effects by modulating microglia activation and polarization, suppressing inflammatory responses, and ameliorating nerve injury through the mediation of microglia and various associated pathways (such as NF-κB signaling pathway, Toll-like signaling pathway, Notch signaling pathway, AMPK signaling pathway, MAPK signaling pathway, among others). Consequently, this article focuses on microglia as a therapeutic target, reviewing relevant pathway of literature on TCHMs to mitigate neuroinflammation and mediate IS injury, while also exploring research on drug delivery of TCHMs. The ultimate goal is to provide new insights that can contribute to the clinical management of IS using TCHMs.

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Gypenoside Pretreatment Alleviates the Cerebral Ischemia Injury via Inhibiting the Microglia-Mediated Neuroinflammation

Cited by 3 publications

References 44 publications

Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells

Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells

Buyang Huanwu Decoction promotes neurovascular remodeling by modulating astrocyte and microglia polarization in ischemic stroke rats

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

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