Gytomegalovirus Infections with Reference to Isolations from Lymph Nodes and Blood.

Stulberg, Cyril S.; Zuelzer, Wolf W.; Page, R. H.; Brough, P. E. Taylor

doi:10.3181/00379727-123-31651

Cited by 36 publications

(12 citation statements)

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“…Recently, it was reported that murine CMV experimentally causes an acute non-fatal hepatitis [8] and that human CMV also presents a problem because of the possibility of its being a cause of neonatal hepatitis [2,19] or a disease called CMV-mononucleosis [10][11][12]. As shown in the case of E.N.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus Infection in Children in Japan

Chiba¹,

Ohsaki²,

Hanazono³

et al. 1968

Japanese Journal of Microbiology

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An attempt to isolate cytomegalovirus (CMV) from specimens obtained from children with various diseases was carried out from June, 1966 thru August, 1967. Forty-five strains of CMV were isolated from 21 cases of 135 children examined. Success in isolation was most frequently observed in children ranging in age from 5 months to 4 years. Serological investigations revealed a rate of incidence of complement-fixing antibodies against CMV was over 90% in the newborn, decreased to 60% in infancy, and gradually increased after 10 years of age. The highest rate of primary infection incidence was in early infancy and it was noted that lower age infants showed a marked tendency to become persistent virus cxcreters.

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Section: Discussionmentioning

confidence: 99%

Cytomegalovirus Infection in Children in Japan

Chiba¹,

Ohsaki²,

Hanazono³

et al. 1968

Japanese Journal of Microbiology

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“…Cytomegalic cells were demonstrated in 2 of the 4 virologically positive specimens. Stulberg et al (1966) could also recover CMV from liver biopsy material or blood specimen of 2 patients with neonatal hepatitis. On the other hand, Medearis (1964) reported the failure of CMV recovery from 21 infants with liver diseases of unknown etiology.…”

Section: Isolations From Infants With Various Diseasesmentioning

confidence: 99%

Primary Cytomegalovirus Infection and Liver Involvement in Early Infancy

Chiba

Hori

Kawamura

et al. 1975

Tohoku J. Exp. Med.

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“…In contrast to immunocompromised hosts, CMV isolation from blood of seropositive healthy individuals is rarely successful, and even PCR could not detect CMV DNA in peripheral blood from normal CMV-seropositive individuals (Shibata et al 1988). However, during the acute phase of infection such as CMV hepatitis and CMV mononucleosis, the virus can be isolated from blood of these patients (Rinaldo et al 1977;Stulberg et al 1966). Our work is still in the early phases of development, CMV genome was detected in blood from a patient who had abnormal liver-function tests in the course of primary CMV infection.…”

Section: Discussionmentioning

confidence: 99%

“…However, in a small percentage of infected children, CMV Offprint requests to: M. Shibata could be a cause of illnesses such as hepatitis and an infectious-mononucleosis-like syndrome. CMV has been recovered from the blood of patients with hepatitis (Stulberg et al 1966), but usually not from the blood of CMV-seropositive blood donors (Kane et al 1975). Hanshaw et al (1965) reported that abnormal liverfunction tests were more frequent in urinary virus-positive than in control children.…”

Section: Introductionmentioning

confidence: 99%

Human cytomegalovirus infection during childhood: detection of viral DNA in peripheral blood by means of polymerase chain reaction

Shibata

Morishima

Terashima

et al. 1990

Med Microbiol Immunol

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Polymerase chain reaction (PCR) technique was applied to detect cytomegalovirus (CMV) DNA. Two pairs of synthetic oligonucleotide primers were used to amplify DNA from the immediate early 1 and the late antigen genes of CMV, respectively. Either primer sets could detect as few as 0.01 plaque-forming unit of CMV strain AD 169 by Southern blot hybridization. Sixteen CMV clinical isolates were examined and all were found to be positive by the both primer sets. The PCR was used to detect CMV DNA in peripheral blood from six children with elevated anti-CMV antibody titers, who showed abnormal liver-function tests. In three immunocompromised patients, all blood samples were positive for CMV DNA. In three immunocompetent young infants with primary CMV infection, CMV DNA was detected from peripheral blood of one patient during acute phase. Presence of CMV DNA in peripheral blood seemed to be related with the extent of CMV infection, and possibly diagnostic for CMV hepatitis.

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Gytomegalovirus Infections with Reference to Isolations from Lymph Nodes and Blood.

Cited by 36 publications

References 0 publications

Cytomegalovirus Infection in Children in Japan

Cytomegalovirus Infection in Children in Japan

Primary Cytomegalovirus Infection and Liver Involvement in Early Infancy

Human cytomegalovirus infection during childhood: detection of viral DNA in peripheral blood by means of polymerase chain reaction

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