2022
DOI: 10.1101/2022.10.10.511514
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Gαs slow conformational transition upon GTP binding and a novel Gαs regulator

Abstract: G proteins are major signaling partners for G protein–coupled receptors (GPCRs). Although stepwise structural changes during GPCR–G protein complex formation and guanosine diphosphate (GDP) release have been reported, no information is available with regard to guanosine triphosphate (GTP) binding. Here, we used a novel Bayesian integrative modeling framework that combines data from hydrogen–deuterium exchange mass spectrometry, tryptophan–induced fluorescence quenching, and metadynamics simulations to derive a… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 105 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?