GС-MS quantification of free and esterified fatty acids in blood plasma

An additional informative tool in the diagnosis of cardiovascular diseases in the early stages can be the analysis of changes in the fatty acid profile, which can be considered as a marker of various pathological conditions. The study of the effects of fatty acids and the mechanisms of changes in the fatty acid profile in connection with cardiovascular diseases remains relevant. We have analyzed modern data from foreign and domestic literature on issues related to the importance of fatty acids as possible markers in the diagnosis of cardiovascular diseases. Basic information about the structure of fatty acids, their functions in the human body, the relationship between the level of free fatty acids and indicators of the development of pathological processes of the cardiovascular system is presented. The factors influencing the dynamics of fatty acid concentrations both in normal conditions and during the development of pathological processes are reflected. The processes of biochemical modification of the fatty acid composition of the lipid matrix of the cell membrane are considered. The expediency of using fatty acids, together with some protein markers in the diagnosis of diseases of the cardiovascular system, has been shown. The collection and analysis of the accumulated information on the role of fatty acids helps to optimize the use of laboratory markers to determine the stages of pathogenesis of circulatory organ damage, to develop a system for evaluating the effectiveness of therapy for cardiovascular diseases, and to create a set of laboratory and instrumental tests for monitoring the condition of patients.

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Current views on the role of fatty acids in the diagnosis of cardiovascular diseases (review)

Astafeva

Zharkov

Ясенявская

et al. 2021

Sibirskij nauchnyj medicinskij zhurnal

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Identification of Biomarkers of Exposure and Effect of 1,4-Dichlorohexafluorobutene-2

Ukolov¹,

Shachneva²,

Radilov³

2019

Toksikologičeskij vestnik

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Spectrum of esterified fatty acids of the omega-3 and omega-6 in the blood of persons with vibration pathology

Zhurba

Меринов

Alekseenko

et al. 2021

Hygiene and Sanitation

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Introduction. Vibration is one of the leading unfavourable physical factors of the working environment and leads to vibration disease (VD) development. The study of metabolic profiles of markers of fatty acids (FA) metabolism is one of the directions in the early diagnosis of vascular diseases and metabolic syndrome (MS), caused, among other things, by exposure to vibration. The aim of this work is to study the spectrum of esterified fatty acids of the omega-3 and omega-6 families in the blood of patients with vibration disease (VD) and combination with metabolic syndrome (MS). Materials and methods. The study involved 66 people, divided into two groups: Group I - 34 patients with an established diagnosis of VD; Group II - 32 patients with an established diagnosis of VD in combination with metabolic syndrome (MS). The levels of esterified forms (EF) of polyunsaturated fatty acids (PUFA) of the ω-3 and ω-6 families in blood plasma samples were determined using the method of gas chromatography-mass spectrometry on an Agilent 7890A gas chromatograph with an Agilent 5975C mass selective detector. Results. The distribution of quantitative indices of PUFA of the ω-3 and ω-6 families in the examined groups was studied. In VD patients with MS, compared with VD patients, there was a statistically significant increase in the level of eicosapentaenoic, α-linolenic acids of the ω-3 family, the sum of ω-3 PUFAs, γ-linolenic and linoleic acids of the ω-6 family. Conclusion. The study of the quantitative indices of EF of the families ω-3 and ω-6 in the blood plasma of VD patients with MS showed the levels of ω-6 to be 4.5-5.4 times statistically higher than the levels of ω-3 fatty acids.

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GС-MS quantification of free and esterified fatty acids in blood plasma

Cited by 4 publications

References 6 publications

Current views on the role of fatty acids in the diagnosis of cardiovascular diseases (review)

Current views on the role of fatty acids in the diagnosis of cardiovascular diseases (review)

Identification of Biomarkers of Exposure and Effect of 1,4-Dichlorohexafluorobutene-2

Spectrum of esterified fatty acids of the omega-3 and omega-6 in the blood of persons with vibration pathology

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