H-2 Histamine Receptors

Hirschowitz, B I

doi:10.1146/annurev.pa.19.040179.001223

Cited by 86 publications

(28 citation statements)

References 100 publications

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“…Histamine-induced changes in the permeability of small vessels were obviously mediated by Н1 receptors, whereas the role of Н2 receptors in small arteriole contractions is still uncertain. The exact ratio of Н1-and Н2-receptor involvements in vascular responses to histamine in the different animal species is variable [21].…”

Section: Histaminementioning

confidence: 99%

Structure and Function of Smooth Muscle with Special Reference to Mast Cells

Vodenicharov¹

2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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Section: Histaminementioning

confidence: 99%

Structure and Function of Smooth Muscle with Special Reference to Mast Cells

Vodenicharov¹

2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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“…1 B and E). However, the contractions produced by high concentrations of histamine were resistant to mepyramine (up to 10-6 M) or cimetidine (10-6 M), an H1-or H2-receptor antagonist, respectively (HIRscHowITZ, 1979). After mechanical removal of the endothelial cells, histamine and ACh enhanced the contraction produced by the K solution ( Fig.…”

Section: Resultsmentioning

confidence: 89%

Direct and indirect actions of acetylcholine and histamine on intrapulmonary artery and vein muscles of the rat.

Chen

Suzuki

1989

Jpn.J.Physiol

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The effects of ACh and histamine on electrical and mechanical properties of intrapulmonary artery and vein muscles were studied in rats. In the artery, ACh and histamine indirectly relaxed the precontracted muscles in high-[K]0 solution via the release of endothelium-derived relaxing factor (EDRF) from the endothelial cells, and also produced contractions by acting directly to the muscles. ACh and histamine elicited a transient hyperpolarization of the arterial smooth muscle membrane mainly due to an increase in K permeability, only in the presence of endothelial cells. In the absence of endothelial cells, histamine and ACh depolarized the arterial smooth muscles. The intrapulmonary vein consisted of the invaded cardiac muscles; and ACh, but not histamine, hyperpolarized the membrane of these muscles by an increase in K permeability, with no relationship to the endothelial cells. It is concluded that in the rat intrapulmonary artery, ACh and histamine elicit excitatory and inhibitory responses in these vascular muscles in direct and indirect manners. The indirect actions involve relaxing and hyperpolarizing factors released from the arterial endothelial cells. ACh but not histamine elicited inhibitory responses to the intrapulmonary vein muscles in a direct manner.

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“…The antisecretory pattern obtained with mianserin is unlike that obtained with either the histamine H2-receptor antagonists, which powerfully inhibit all forms of gastric secretion (Hirschowitz, 1979), or LM 24056 which inhibits nocturnal secretion better than pentagastrin-stimulated secretion (Boyd & Wormsley, 1981). The gastric inhibitory effects of mianserin also differ from trimipramine, which weakly inhibits pentagastrin-stimulated secretion (Myren, 1980) and actually stimulates nocturnal output of acid and pepsin (Boyd et al, in preparation).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of pentagastrin‐stimulated and overnight gastric secretion by mianserin.

Wilson¹,

Read²,

Boyd³

et al. 1983

Brit J Clinical Pharma

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1 The effects of mianserin (60 mg) have been studied on nocturnal and pentagastrin‐stimulated gastric secretion. 2 Mianserin reduced pentagastrin‐stimulated gastric acid secretion by 38%, pepsin by 40% and secretory volume by 45% during a 1 h test. 3 Twelve‐hour overnight secretion of acid was reduced by 37%, while secretion of pepsin was reduced by 43% and secretory volume by 51%. 4 No adverse effects were noted. 5 These findings, which achieve statistical significance, suggest the need for further study to evaluate the possible role of mianserin in the therapy of duodenal ulcer disease.

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H-2 Histamine Receptors

Cited by 86 publications

References 100 publications

Structure and Function of Smooth Muscle with Special Reference to Mast Cells

Structure and Function of Smooth Muscle with Special Reference to Mast Cells

Direct and indirect actions of acetylcholine and histamine on intrapulmonary artery and vein muscles of the rat.

Inhibition of pentagastrin‐stimulated and overnight gastric secretion by mianserin.

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