H/ACA snRNP–dependent ribosome biogenesis regulates translation of polyglutamine proteins

Breznak, Shane; Peng, Yingshi; Deng, Limin; Kotb, Noor M.; Flamholz, Zachary; Rapisarda, Ian T.; Martin, Elliot T.; LaBarge, Kara A.; Fabris, Dan; Gavis, Elizabeth R.; Rangan, Prashanth

doi:10.1126/sciadv.ade5492

Cited by 4 publications

(2 citation statements)

References 61 publications

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“…These modifications significantly impact ribosome functionality. For instance, they enhance the structural stability of ribosomes, boost translation efficiency, and ensure accuracy in protein synthesis [16,84,85]. Moreover, they enable adaptation to environmental stress conditions and potentially contribute to the fine-tuning of ribosomal functions [15].…”

Section: Increased Rps6 and Rpl19mentioning

confidence: 99%

Decoding Ribosome Heterogeneity: A New Horizon in Cancer Therapy

Gelfo,

Venturi,

Zacchini

et al. 2024

Biomedicines

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The traditional perception of ribosomes as uniform molecular machines has been revolutionized by recent discoveries, revealing a complex landscape of ribosomal heterogeneity. Opposing the conventional belief in interchangeable ribosomal entities, emerging studies underscore the existence of specialized ribosomes, each possessing unique compositions and functions. Factors such as cellular and tissue specificity; developmental and physiological states; and external stimuli, including circadian rhythms, significantly influence ribosome compositions. For instance, muscle cells and neurons are characterized by distinct ribosomal protein sets and dynamic behaviors, respectively. Furthermore, alternative forms of ribosomal RNA (rRNAs) and their post-transcriptional modifications add another dimension to this heterogeneity. These variations, orchestrated by spatial, temporal, and conditional factors, enable the manifestation of a broad spectrum of specialized ribosomes, each tailored for potentially distinct functions. Such specialization not only impacts mRNA translation and gene expression but also holds significant implications for broader biological contexts, notably in the realm of cancer research. As the understanding of ribosomal diversity deepens, it also paves the way for exploring novel avenues in cellular function and offers a fresh perspective on the molecular intricacies of translation.

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Section: Increased Rps6 and Rpl19mentioning

confidence: 99%

Decoding Ribosome Heterogeneity: A New Horizon in Cancer Therapy

Gelfo,

Venturi,

Zacchini

et al. 2024

Biomedicines

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show abstract

“…The intronic H/ACA snoRNA leads to pseudouridylation in the large rRNA subunit at positions 2258 and 2260 and is termed snR191 in yeast and hU19 in humans; the highly conserved ψ modification is beneficial for the cell 181 . Specifically, in oocytes, ψ modification of rRNA through the H/ACA box snRNP complex is required during oogenesis 182 . Furthermore, H/ACA box guide RNAs are composed of two hairpins that carry the internal ψ guide loops that allow site-dependent ψ of spliceosomal and ribosomal RNAs in humans.…”

Section: ′-O-methylation (2′-o-me)mentioning

confidence: 99%

Molecular insights into regulatory RNAs in the cellular machinery

Yang,

Kim,

Yang

et al. 2024

Exp Mol Med

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It is apparent that various functional units within the cellular machinery are derived from RNAs. The evolution of sequencing techniques has resulted in significant insights into approaches for transcriptome studies. Organisms utilize RNA to govern cellular systems, and a heterogeneous class of RNAs is involved in regulatory functions. In particular, regulatory RNAs are increasingly recognized to participate in intricately functioning machinery across almost all levels of biological systems. These systems include those mediating chromatin arrangement, transcription, suborganelle stabilization, and posttranscriptional modifications. Any class of RNA exhibiting regulatory activity can be termed a class of regulatory RNA and is typically represented by noncoding RNAs, which constitute a substantial portion of the genome. These RNAs function based on the principle of structural changes through cis and/or trans regulation to facilitate mutual RNA‒RNA, RNA‒DNA, and RNA‒protein interactions. It has not been clearly elucidated whether regulatory RNAs identified through deep sequencing actually function in the anticipated mechanisms. This review addresses the dominant properties of regulatory RNAs at various layers of the cellular machinery and covers regulatory activities, structural dynamics, modifications, associated molecules, and further challenges related to therapeutics and deep learning.

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Comparative Transcriptome Analysis Reveals the Role of Ribosome Reduction in Impeding Oogenesis in Female Triploid Crassostrea Gigas

Yang,

Yu,

2024

Mar Biotechnol

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H/ACA snRNP–dependent ribosome biogenesis regulates translation of polyglutamine proteins

Cited by 4 publications

References 61 publications

Decoding Ribosome Heterogeneity: A New Horizon in Cancer Therapy

Decoding Ribosome Heterogeneity: A New Horizon in Cancer Therapy

Molecular insights into regulatory RNAs in the cellular machinery

Comparative Transcriptome Analysis Reveals the Role of Ribosome Reduction in Impeding Oogenesis in Female Triploid Crassostrea Gigas

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