H-bond-type thermo-responsive schizophrenic copolymers: The phase transition correlation with their parent polymers and the improved protein co-assembly ability

Lai, Jsm; Sun, Jialin; Li, Chen; Lu, Jianlei; Tian, Yueyi; Liu, Yuting; Zhao, Chuanzhuang; Zhang, Mingming

doi:10.1016/j.jcis.2023.07.153

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…This kind of dual thermoresponsive polymers, also known as “schizophrenic” polymers, can usually be obtained by coalescing two or more blocks of different critical temperatures. , For example, Zhou et al synthesized a dual temperature-sensitive triblock copolymer where both LCST and UCST features were combined, and they utilized the self-assembly and gelling behavior for potential biomedical applications . Kermagoret et al reported the synthesis of N -vinyl caprolactam (NVCL) and NVP-based ABA triblock copolymers, where they evaluated the effect of block lengths on LCSTs and self-assembly behavior .…”

Section: Introductionmentioning

confidence: 99%

Polymer Nanoparticles for Preferential Delivery of Drugs Only by Exploiting the Slightly Elevated Temperature of Cancer Cells and Real-Time Monitoring of Drug Release

Pal,

Kola,

Samanta

et al. 2024

Biomacromolecules

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Rapid proliferation and a faster rate of glycolysis in cancer cells often result in an elevated local temperature (40−43 °C) at the tumor site. Nanoparticles prepared from polymers with two lower critical solution temperatures (LCSTs) can be utilized to take advantage of this subtle temperature elevation to deliver anticancer drugs preferably to the cancer cells, thereby enhancing the overall therapeutic efficacy and reducing side effects. In this direction, we synthesized N-vinyl-2-pyrrolidone (NVP) and substituted NVP (sub-NVP: C 2 -NVP, C 4 -NVP)-based polymers with precisely controlled LCSTs by varying the ratio of NVP and sub-NVP. The first LCST (LCST1) was kept below 37 °C to promote self-assembly, drug loading, and structural stability in physiological conditions and the second LCST (LCST2) was in the range of 40−43 °C to ensure mild hyperthermia-induced drug release. Additionally, covalent attachment of tetraphenylethylene (TPE, AIEgen) resulted in aggregation-induced emission in thermoresponsive micellar nanoparticles in which TPE acted as a Forster Resonance Energy Transfer (FRET) pair with the loaded anticancer drug doxorubicin (DOX). Tracking of FRET-induced fluorescence recovery of TPE molecules was utilized to confirm the real-time thermoresponsive release of DOX from nanoparticles and eventual localization of TPE in the cytoplasm and DOX in the nucleus. In vitro cellular studies such as cytotoxicity, cellular uptake, and thermoresponsive drug release showed that the DOXloaded polymeric nanoparticles were nontoxic to normal cells (HEK-293) but significantly more effective in cancer cells (MCF-7) at 40 °C. To our knowledge, this is the first report of preferential delivery of anticancer drugs only by exploiting the slightly elevated temperature of cancer cells.

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Section: Introductionmentioning

confidence: 99%

Polymer Nanoparticles for Preferential Delivery of Drugs Only by Exploiting the Slightly Elevated Temperature of Cancer Cells and Real-Time Monitoring of Drug Release

Pal,

Kola,

Samanta

et al. 2024

Biomacromolecules

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Smart Materials for Biocatalysis Regulation through Thermoresponsive Polymers

de Barros,

Theisen,

Durigon

et al. 2024

ChemCatChem

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Temperature‐responsive biocatalytic hybrid materials offer several advantages, such as improved stability, enhanced catalytic efficiency, and biocatalysts longer lifespan. Combining enzymes with thermoresponsive polymers in a strategically manner allows a smarter modulation of enzyme activity in response to temperature changes. Thermoresponsive materials can act as protective barriers for enzymes or enable controlled exposure and release depending on temperature variations, expanding enzyme applications in diverse environments. This review aims to comprehensively present the design strategies for enzyme‐polymer hybrid materials with thermoresponsive properties, and to address the advantages, applications, and challenges involved for a rational control of biocatalytic systems. The study emphasizes the importance of creating stimuli‐responsive biocatalytic hybrid materials for diverse applications, ranging from controlled drug delivery to industrial catalysis. Furthermore, we outline key research opportunities and future perspectives for studies within this scope.

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H-bond-type thermo-responsive schizophrenic copolymers: The phase transition correlation with their parent polymers and the improved protein co-assembly ability

Cited by 2 publications

References 55 publications

Polymer Nanoparticles for Preferential Delivery of Drugs Only by Exploiting the Slightly Elevated Temperature of Cancer Cells and Real-Time Monitoring of Drug Release

Polymer Nanoparticles for Preferential Delivery of Drugs Only by Exploiting the Slightly Elevated Temperature of Cancer Cells and Real-Time Monitoring of Drug Release

Smart Materials for Biocatalysis Regulation through Thermoresponsive Polymers

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