H�ckel and M�bius cyclic conjugated molecules

Mizoguchi, Noriyuki

doi:10.1007/bf01200830

Cited by 3 publications

(4 citation statements)

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“…4 4 . Mizoguchi et al (1992) found CD3 5 homodimers on T cells from tumor-bearing mice replaced by a structurally related y-y homodimer from the FcR for IgE. Consistent with these findings, an 8to 10-kDa off-diagonal spot corresponding to a possible y-y homodimer was resolved on the gel from TIL, non-cancerous colon, as well as patients' PBL, whereas T cells from normal PBL lacked this spot (Fig.…”

Section: Biochemical Analysis Of the Tcr Complex On T Cells Infiltratsupporting

confidence: 75%

“…4). Conclusive identification of this spot as a y-y homodimer, however, necessitates the use of an anti-FcR y MAb, as in the murine cancer model (Mizoguchi et al, 1992) and as mentioned also by Gunji et al (1994) for patients with colorectal carcinomas.…”

Section: Modulation Of 5 Chain and Surface Cd3 E Expression On T Cellmentioning

confidence: 99%

“…Evidence exists, however, that CD3 complexes containing FcR y, while being able to form functional TCR complexes, may differ with regard to signalling functions and their association with tyrosine kinases as compared to CD3 complexes containing CD3 < (Mizoguchi et al, 1992;Ohno et nl., 1993;Letourneur and Klausner, 1991). The possibility that these differences in TCR activation may be part of the mechanism behind the suppressed immune response in individuals with cancer should be considered.…”

Section: Modulation Of 5 Chain and Surface Cd3 E Expression On T Cellmentioning

confidence: 99%

“…The low affinity FcR for IgC found on human natural killer (NK) cells (FcyRIIIA a, or CD16) has also been found associated with 5-5 homodimers and <-y heterodimers (Anderson et al, 1990), which might perform analogous roles in the induction of NK-cell-mediated antibodydependent cellular cytotoxicity (Vivier et af., 1991a). Mizoguchi et al (1992) reported a decrease in CD3 < chain levels on T cells from mice bearing an experimental colon carcinoma. We have previously reported that NK cells and tumor-infiltrating lymphocytes (TILs) from patients with colo-rectal carcinomas contained significantly fewer 5 chains than patients' peripheral blood lymphocytes (PBL), which also had less < than normal (Nakagomi et al, 1993).…”

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confidence: 99%

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Alterations in the signal‐transducing molecules of T cells and nk cells in colorectal tumor‐infiltrating, gut mucosal and peripheral lymphocytes: Correlation with the stage of the disease

Matsuda

Petersson

Lenkei³

et al. 1995

Intl Journal of Cancer

187

118

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T cells from mice bearing an experimental colon carcinoma, and from patients with colorectal and renal carcinomas, have atypical T-cell receptors (TCR). In the present study, further characterization of modulations in CD3- and CD16-associated zeta chain in peripheral blood lymphocytes (PBL) and tumor-infiltrating lymphocytes (TIL) from colorectal carcinomas was performed. Relative to PBL, the percentage of natural killer (NK) cells among fresh TIL was reduced, while a higher proportion of T cells expressing HLA-DR was found. As previously reported, we found significantly reduced levels of the CD3- and CD16-associated zeta chain in TIL and, to a lesser extent, also in patients' PBL. Levels of zeta chain in T and NK cells from non-cancerous colorectal tissue from patients were lower than in PBL but higher than in TIL, with a direct relationship between levels of this signal-transducing molecule and the distance from the tumor. In addition, zeta levels correlated with the Dukes' stage of the disease, since PBL from patients with lymph-node involvement or distant organ metastases (Dukes' stages C and D) had significantly less CD3 zeta than patients with localized disease (stages A and B). Patients' T cells also had decreased levels of cell-surface and cytoplasmic CD3 epsilon. We also observed reduced levels of the TCR accessory molecules CD4 and CD8, mainly on TIL but to a lesser extent also on patients' PBL. Biochemical analysis of anti-CD3 epsilon-immunoprecipitated TCR complexes demonstrated that the CD3 complex was not associated with the zeta chain, either on TIL or on PBL or on lymphocytes from non-cancerous colon tissue, suggesting a defect in the assembly of the TCR complex. Following several days of in vitro culture with recombinant interleukin-2 and phytohemagglutinin, anti-CD3 or anti-CD2 monoclonal antibodies (MAbs), levels of CD3 zeta chain as well as of cell surface CD3 epsilon were normalized. Our findings suggest an abnormal expression as well as assembly of several different signal-transducing molecules of T cells and NK cells, which correlate with the stage of the disease in patients with colorectal carcinomas.

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Section: Biochemical Analysis Of the Tcr Complex On T Cells Infiltratsupporting

confidence: 75%

Section: Modulation Of 5 Chain and Surface Cd3 E Expression On T Cellmentioning

confidence: 99%

Section: Modulation Of 5 Chain and Surface Cd3 E Expression On T Cellmentioning

confidence: 99%

mentioning

confidence: 99%

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Alterations in the signal‐transducing molecules of T cells and nk cells in colorectal tumor‐infiltrating, gut mucosal and peripheral lymphocytes: Correlation with the stage of the disease

Matsuda

Petersson

Lenkei³

et al. 1995

Intl Journal of Cancer

187

118

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Cycle energy and its size dependence

Gutman

2020

Discrete Applied Mathematics

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The chemical roots of the matching polynomial

Chauvin

Lepetit

Fowler

et al. 2010

Phys. Chem. Chem. Phys.

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The interpretation of topological resonance energy (TRE), the mathematical measure of energetic chemical aromaticity at the Hückel level of theory, is revisited by providing a concise analysis of the matching polynomial of a chemical graph. Whereas the matching (or acyclic) polynomial is not a properly characteristic polynomial in general, it is the arithmetic mean of the characteristic polynomials of the corresponding Hückel and Möbius chemical graphs. For unicyclic graphs, the roots of the matching polynomial (serving to calculate the TRE values) can be graphically approximated from generalized Frost-Musulin-Zimmermann diagrams, the results becoming exact for annulenic monocycles. The matching polynomial is also shown to be a weighted sum of characteristic polynomials of subgraphs: the whole graph itself and the exocyclic graphs obtained by suppression of individual circuits. The performance of these ring twisting and ring masking processes is compared to that of the previously proposed ring opening process. Further prospects for the interpretation and approximation of TRE are discussed.

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H�ckel and M�bius cyclic conjugated molecules

Cited by 3 publications

References 39 publications

Alterations in the signal‐transducing molecules of T cells and nk cells in colorectal tumor‐infiltrating, gut mucosal and peripheral lymphocytes: Correlation with the stage of the disease

Alterations in the signal‐transducing molecules of T cells and nk cells in colorectal tumor‐infiltrating, gut mucosal and peripheral lymphocytes: Correlation with the stage of the disease

Cycle energy and its size dependence

The chemical roots of the matching polynomial

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