H.M.'s Language Production Deficits: Implications for Relations between Memory, Semantic Binding, and the Hippocampal System

MacKay, Donald G.; Burke, Deborah M.; Stewart, Rachel

doi:10.1006/jmla.1997.2544

Cited by 72 publications

(97 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hippocampus and the parahippocampal cortex has been thought to be exclusively involved in episodic memory, however, recent neuroimaging research has shown the importance of these regions in semantic processing [48,49]. The role of the hippocampal formation in semantic tasks is also supported by the findings of reduced language production capacity in patients with hippocampal damage [50]. …”

Section: Hippocampal Activationsupporting

confidence: 54%

Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network

Gauffin¹,

Ettinger-Veenstra²,

Landtblom³

et al. 2013

Epilepsy & Behavior

View full text Add to dashboard Cite

We aimed to study the effect of a potential default mode network (DMN) dysfunction on language performance in epilepsy. Language dysfunction in focal epilepsy has previously been connected to brain damage in language associated cortical areas. In this work, we studied generalized epilepsy (GE) without focal brain damage, to see if the language function was impaired.We used functional magnetic resonance imaging (fMRI) to investigate if the DMN was involved. Eleven persons with GE and 28 healthy controls were examined with fMRI during a sentence reading task. We could demonstrate impaired language function, reduced suppression of DMN, and, specifically, an inadequate suppression of activation in the left anterior temporal lobe and the posterior cingulate cortex, as well as an aberrant activation in the right hippocampal formation. Our results highlight the presence of language decline in people with epilepsy of not only focal, but also generalized origin.

show abstract

Section: Hippocampal Activationsupporting

confidence: 54%

Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network

Gauffin¹,

Ettinger-Veenstra²,

Landtblom³

et al. 2013

Epilepsy & Behavior

View full text Add to dashboard Cite

show abstract

“…where "make it" can mean to make a physical object, or to achieve a goal, or to arrive on time). Compared to healthy volunteers, H.M. detected significantly fewer sentence ambiguities (MacKay et al, 1998a,b); his descriptions of the ambiguous sentences were rated as less clear, concise, and coherent (MacKay et al, 1998a); and his conversations about his early childhood were rated by blind judges as less coherent and comprehensible (MacKay et al, 1998a).…”

Section: A Dissociation Within Lexical Memory? Learning Vs Retrievalmentioning

confidence: 99%

Bilateral medial temporal lobe damage does not affect lexical or grammatical processing: Evidence from amnesic patient H.M.

2001

View full text Add to dashboard Cite

In the most extensive investigation to date of language in global amnesia, we acquired data from experimental measures and examined longitudinal data from standardized tests, to determine whether language function was preserved in the amnesic patient H.M. The experimental measures indicated that H.M. performed normally on tests of lexical memory and grammatical function, relative to age- and education-matched control participants. Longitudinal data from four Wechsler subtests (Information, Comprehension, Similarities, and Vocabulary), that H.M. had taken 20 times between 1953 (preoperatively) and 2000, indicated consistent performance across time, and provided no evidence of a lexical memory decrement. We conclude that medial temporal lobe structures are not critical for retention and use of already acquired lexical information or for grammatical processing. They are, however, required for acquisition of lexical information, as evidenced in previous studies revealing H.M.'s profound impairment at learning new words.

show abstract

“…However, all three claims of Kensinger et al (2001) are in conflict with other evidence indicating that: (1) H.M. exhibits recent deficits in processing low-frequency (LF) words James, 2001, 2002); (2) from 1983 to 1997, H.M. exhibited exaggerated age-linked declines in processing LF words that he knew and used correctly in 1970 James, 2001, 2002); (3) H.M. exhibited syntax-level processing deficits in more than 30 sources of evidence from 1967-1973(Lackner, 1974MacKay, Burke, and Stewart, 1998a;MacKay, Stewart, and Burke, 1998b) to 1997-1999, 2002MacKay, James, Taylor, and Marian, in press).…”

Section: Introductionmentioning

confidence: 98%

Aging, memory, and language in amnesic H.M.

MacKay

2006

Hippocampus

Self Cite

View full text Add to dashboard Cite

H.M.'s Language Production Deficits: Implications for Relations between Memory, Semantic Binding, and the Hippocampal System

Cited by 72 publications

References 73 publications

Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network

Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network

Bilateral medial temporal lobe damage does not affect lexical or grammatical processing: Evidence from amnesic patient H.M.

Aging, memory, and language in amnesic H.M.

Contact Info

Product

Resources

About