H. Pylori in a gastric schwannoma: a case report

Abstract

Schwannomas are benign, often asymptomatic, slow-growing tumors that originate from Schwann cells of the neural sheath. Although H. Pylori has been associated with gastric adenocarcinoma, there has never been a recorded association with schwannoma formation. We present a 64-year-old woman who underwent a laparoscopic partial wedge gastrectomy for an incidentally discovered gastric mass. Histologic examination was consistent with schwannoma; however, chronic inflammation with microorganisms morphologically consistent with H. Pylori was also present. This case suggests the first recorded case of H. Pylori in an immunohistochemically confirmed gastric schwannoma.

Gastric schwannoma: report of two cases and review of the literature

“…Presence of H. pylori in the extracted specimen, as found in one of our patients, has only recently been presented in another case report [11]. Despite the fact that the role of microorganism has been well established in the pathogenesis of gastric adenocarcinoma, in case of gastric schwannomas the correlation is uncertain [12,13].…”

Gastric Schwannomas Misdiagnosed as GIST: A Comparative Study of Clinic Strategies Based on Membrane Marker Detection

“…In addition, MRI is another beneficial technique to identify the location and the tumors' invasion of adjacent vessels and organs [4]. MRI shows the superiority to CT in defining tumor extent, central necrosis and hemorrhage.…”

“…Histologically, the typical features of gastric schwannoma include mainly atypical spindle cells arranging in a microtrabecular-microfascicular pattern and a peritumoral lymphoid cuff, with occasional germinal centers [3]. In addition, this disease has the highly unique traits of immunohistochemical positivity for S-100 protein, and negativity for C-kit, CD117, CD34, desmin [4,5].…”