1978
DOI: 10.1113/expphysiol.1978.sp002428
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H1 AND H2 HISTAMINE ACTIONS ON LUNG VESSELS; THEIR RELEVANCE TO HYPOXIC VASOCONSTRICTION

Abstract: Pulmonary vasomotor actions of histamine and the possible relationship of histamine to hypoxic pulmonary vasconstriction were studied in anaesthetized cats with one lobe of lung perfused at constant flow and in isolated perfused rat and ferret lungs. In the cat histamine caused dilatation, biphasic responses and constriction with increasing doses. Histamine induced dilatation was better demonstrated during hypoxic vasoconstriction and was reduced by an H2 histamine antagonist; constriction with histamine was a… Show more

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Cited by 24 publications
(10 citation statements)
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“…The role of histamine H1‐ and H2‐receptors in the lung has previously been investigated. Various studies suggest that increased lung permeability and vasodilatation are mediated by H2 receptors, while the bronchoconstriction is ascribed primarily to an H1‐receptor mechanism . However, H1‐receptors have also been implicated in vasoconstriction in a lung circuit at higher histamine concentrations .…”
Section: Discussionmentioning
confidence: 99%
“…The role of histamine H1‐ and H2‐receptors in the lung has previously been investigated. Various studies suggest that increased lung permeability and vasodilatation are mediated by H2 receptors, while the bronchoconstriction is ascribed primarily to an H1‐receptor mechanism . However, H1‐receptors have also been implicated in vasoconstriction in a lung circuit at higher histamine concentrations .…”
Section: Discussionmentioning
confidence: 99%
“…Treatment with a H2 receptor antagonist was without effect on the acute phase of the HPV response in cats (Barer et al . ), but potentiated the response in dogs (Tucker et al . ).…”
Section: Other Potential Modulators Of Hypoxic Pulmonary Vasoconstricmentioning
confidence: 97%
“…Histamine participates in a number of physiological processes particularly those of the cardiovascular system (1,5,6,9,32,34) and is largely involved in inflammatory and anaphylactic reaction (3,4). As identified on a physiological and pharmacological basis, its effects are mediated by two types of receptors: H, receptors, specifically inhibited by classical antihistamines such as mepyramine, and H2 receptors, blocked by antagonists such as cimetidine (8,19,35).…”
mentioning
confidence: 99%