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            S Induces a Suspended Animation-Like State in Mice

Blackstone, Eric; Morrison, Mike; Roth, Mark B.

doi:10.1126/science.1108581

Cited by 767 publications

(589 citation statements)

References 7 publications

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“…However, it remains to be tested whether exposure to H 2 S increases metabolic rates in P. mexicana in a similar fashion as in some sulfide-adapted invertebrates (Gorodezky and Childress 1994;Schneider 1996), in which case the present study would have overestimated differences in overall energy consumption between sulfidic and nonsulfidic populations. Because H 2 S also blocks cytochrome c oxidase (COX) in the mitochondrial respiratory chain (Cooper and Brown 2008), sulfide exposure can also cause metabolic rate depression (Brauner et al 1995;Blackstone et al 2005;Volpato et al 2008), and this may be particularly relevant for the populations investigated here. Unlike other evolutionarily lineages of sulfide spring Poecilia in southern Mexico that have evolved H 2 S-resistant COXs, sulfide spring populations in the Tacotalpa drainage used in the present study exhibit an H 2 S-susceptible COX similar to that found in ancestral nonsulfidic populations (Pfenninger et al 2014).…”

Section: Metabolic Rate Variation In Sulfidic Environmentsmentioning

confidence: 99%

Reduction of Energetic Demands through Modification of Body Size and Routine Metabolic Rates in Extremophile Fish

Passow¹,

Greenway²,

Arias‐Rodríguez³

et al. 2015

Physiological and Biochemical Zoology

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Variation in energy availability or maintenance costs in extreme environments can exert selection for efficient energy use, and reductions in organismal energy demand can be achieved in two ways: reducing body mass or metabolic suppression. Whether long-term exposure to extreme environmental conditions drives adaptive shifts in body mass or metabolic rates remains an open question. We studied body size variation and variation in routine metabolic rates in locally adapted populations of extremophile fish (Poecilia mexicana) living in toxic, hydrogen sulfide-rich springs and caves. We quantified size distributions and routine metabolic rates in wild-caught individuals from four habitat types. Compared with ancestral populations in nonsulfidic surface habitats, extremophile populations were characterized by significant reductions in body size. Despite elevated metabolic rates in cave fish, the body size reduction precipitated in significantly reduced energy demands in all extremophile populations. Laboratory experiments on common garden-raised fish indicated that elevated routine metabolic rates in cave fish likely have a genetic basis. The results of this study indicate that adaptation to extreme environments directly impacts energy metabolism, with fish living in cave and sulfide spring environments expending less energy overall during routine metabolism.

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Section: Metabolic Rate Variation In Sulfidic Environmentsmentioning

confidence: 99%

Reduction of Energetic Demands through Modification of Body Size and Routine Metabolic Rates in Extremophile Fish

Passow¹,

Greenway²,

Arias‐Rodríguez³

et al. 2015

Physiological and Biochemical Zoology

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“…H 2 S can also produce metabolic depression (akin to ''suspended animation'') in small mammals (9,10), and it has been implicated in torpor and hibernation (159,160), anapyrexia (81), and hypoxia-induced radiation resistance (194). H 2 S has also been shown to protect cells from both hypoxiaand hyperoxia-induced redox imbalance and apoptosis (13,83,85,92,101,189,190).…”

Section: General Metabolismmentioning

confidence: 99%

Hydrogen sulfide as an oxygen sensor

Olson

2013

Clinical Chemistry and Laboratory Medicine

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Significance: Although oxygen (O 2 )-sensing cells and tissues have been known for decades, the identity of the O 2 -sensing mechanism has remained elusive. Evidence is accumulating that O 2 -dependent metabolism of hydrogen sulfide (H 2 S) is this enigmatic O 2 sensor. Recent Advances: The elucidation of biochemical pathways involved in H 2 S synthesis and metabolism have shown that reciprocal H 2 S/O 2 interactions have been inexorably linked throughout eukaryotic evolution; there are multiple foci by which O 2 controls H 2 S inactivation, and the effects of H 2 S on downstream signaling events are consistent with those activated by hypoxia. H 2 S-mediated O 2 sensing has been demonstrated in a variety of O 2 -sensing tissues in vertebrate cardiovascular and respiratory systems, including smooth muscle in systemic and respiratory blood vessels and airways, carotid body, adrenal medulla, and other peripheral as well as central chemoreceptors. Critical Issues: Information is now needed on the intracellular location and stoichometry of these signaling processes and how and which downstream effectors are activated by H 2 S and its metabolites. Future Directions: Development of specific inhibitors of H 2 S metabolism and effector activation as well as cellular organelle-targeted compounds that release H 2 S in a timeor environmentally controlled way will not only enhance our understanding of this signaling process but also provide direction for future therapeutic applications. Antioxid. Redox Signal. 22, 377-397.

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“…H 2 S, or aqueous sulphide, elicits diverse physiological responses, including modulation of blood pressure and reduction of ischemia reperfusion injury [3][4][5] , exertion of anti-inflammatory effects 6 and reduction of metabolic rate 7 . The production of H 2 S is catalysed by the two pyridoxal 5′-phosphate-dependent enzymes, cystathionine β-synthase (CBS) 8 , and cystathionine γ-lyase 9 , and indirectly, via a pyridoxal 5′-phosphateindependent enzyme, 3-mercaptopyruvate sulphurtransferase 10 .…”

mentioning

confidence: 99%

Selective fluorescent probes for live-cell monitoring of sulphide

et al. 2011

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Aqueous sulphides, including hydrogen sulphide, have important roles in biological signalling and metabolic processes. Here we develop a selective sulphide-trapping strategy involving sulphide addition to an aldehyde; the resulting hemithioacetal undergoes a michael addition with an adjacent unsaturated acrylate ester to form a thioacetal at neutral pH in aqueous solution. Employing this new strategy, two sulphide-selective fluorescent probes, sFP-1 and sFP-2, were synthesized on the basis of two different fluorophore templates. These probes exhibit an excellent fluorescence increase and an emission maximum shift (sFP-1) in response to na 2 s and H 2 s in a high thiol background as found under physiological conditions. We show the utility of the probes for the selective detection of sulphides, and the capacity of our probes to monitor enzymatic H 2 s biogenesis and image free sulphide in living cells.

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H ₂ S Induces a Suspended Animation-Like State in Mice

Cited by 767 publications

References 7 publications

Reduction of Energetic Demands through Modification of Body Size and Routine Metabolic Rates in Extremophile Fish

Reduction of Energetic Demands through Modification of Body Size and Routine Metabolic Rates in Extremophile Fish

Hydrogen sulfide as an oxygen sensor

Selective fluorescent probes for live-cell monitoring of sulphide

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H 2 S Induces a Suspended Animation-Like State in Mice

Cited by 767 publications

References 7 publications

Reduction of Energetic Demands through Modification of Body Size and Routine Metabolic Rates in Extremophile Fish

Reduction of Energetic Demands through Modification of Body Size and Routine Metabolic Rates in Extremophile Fish

Hydrogen sulfide as an oxygen sensor

Selective fluorescent probes for live-cell monitoring of sulphide

Contact Info

Product

Resources

About

H ₂ S Induces a Suspended Animation-Like State in Mice