H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection

Ma, Rui; Liu, Qiang; Liu, Zimo; Sun, Xu; Jiang, Xinze; Hou, Jiangshan; Zhang, Yumei; Wu, Yulong; Cheng, Mei; Dong, Zhouyan

doi:10.1016/j.actatropica.2023.107012

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…LncRNA Gm16685 is upregulated during S. japonicum infection, and participates in the pathogenesis throughout schistosomiasis by regulating miR-205-5p [ 183 ]. The involvement of lncRNA H19 in S. japonica has also been corroborated, as it governs the hepatic reaction to Praziquantel therapy against S. japonicum infection through the H19 /miR-130b-3p/ Cyp4a14 axis [ 184 ].…”

Section: Lncrnas In Parasitic Zoonosesmentioning

confidence: 99%

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Xu,

He,

Yang

et al. 2024

IJMS

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Zoonoses are diseases and infections naturally transmitted between humans and vertebrate animals. They form the dominant group of diseases among emerging infectious diseases and represent critical threats to global health security. This dilemma is largely attributed to our insufficient knowledge of the pathogenesis regarding zoonotic spillover. Long non-coding RNAs (lncRNAs) are transcripts with limited coding capacity. Recent technological advancements have enabled the identification of numerous lncRNAs in humans, animals, and even pathogens. An increasing body of literature suggests that lncRNAs function as key regulators in zoonotic infection. They regulate immune-related epigenetic, transcriptional, and post-transcriptional events across a broad range of organisms. In this review, we discuss the recent research progress on the roles of lncRNAs in zoonoses. We address the classification and regulatory mechanisms of lncRNAs in the interaction between host and zoonotic pathogens. Additionally, we explore the surprising function of pathogen-derived lncRNAs in mediating the pathogenicity and life cycle of zoonotic bacteria, viruses, and parasites. Understanding how these lncRNAs influence the zoonotic pathogenesis will provide important therapeutic insights to the prevention and control of zoonoses.

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Section: Lncrnas In Parasitic Zoonosesmentioning

confidence: 99%

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Xu,

He,

Yang

et al. 2024

IJMS

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“…In our study, H19 has been found to be aberrantly upregulated in both femoral head tissues and BMSCs. The relationship between H19 and miR-130b has been reported in the regulation of keratinocyte differentiation(Li et al 2017) and in potentiating the effect of praziquantel on liver function(Ma et al 2023); however, this relationship has not yet been explored in the context of SONFH. Motivated by these ndings, we hypothesized that H19 could exert a regulatory in uence on the progression of SONFH by functioning as a sponge for miR-130b-3p.…”

mentioning

confidence: 99%

LncRNA-H19 Promotes Adipogenic Differentiation Disorder by Regulating miR-130b-3p/PPARγ Axis in Steroid-induced Osteonecrosis of Femoral Head

Lin,

Yi,

Zhou

et al. 2024

Preprint

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Steroid-induced osteonecrosis of the femoral head (SONFH) represents a frequent and debilitating orthopedic condition. It is widely believed that the adipogenic/osteogenic differentiation disorder of bone marrow mesenchymal stem cells (BMSCs) contributes to the development of SONFH. However, the regulatory mechanism of long non-coding RNAs (lncRNAs) in the differentiation disorder of BMSCs remains elusive. The expression levels of H19 were detected in both femoral head tissues and BMSCs from patients with SONFH. The role of the lncRNA H19 in SONFH was explored through bioinformatics analysis complemented by relevant validation experiments. Our findings revealed that H19 was significantly up-regulated in SONFH tissues as well as BMSCs. Silencing H19 suppressed BMSC adipogenic differentiation in SONFH and the expression of peroxisome proliferator-activated receptor γ (PPARγ). Furthermore, we found that H19 could interact with miR-130b-3p, and miR-130b-3p could directly inhibit PPARγ expression. In conclusion, this study uncovered that abnormally up-regulated H19 leads to abnormal lipogenic differentiation in SONFH by acting as a sponge for miR-130b-3p and upregulating PPARγ.

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Nicotinamide mitigates visceral leishmaniasis by regulating inflammatory response and enhancing lipid metabolism

Zhou,

Zheng,

Yin

et al. 2024

Parasites Vectors

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Background Currently, treatment regimens for visceral leishmaniasis (VL) are limited because of the presence of numerous adverse effects. Nicotinamide, a readily available and cost-effective vitamin, has been widely acknowledged for its safety profile. Several studies have demonstrated the anti-leishmanial effects of nicotinamide in vitro. However, the potential role of nicotinamide in Leishmania infection in vivo remains elusive. Methods In this study, we assessed the efficacy of nicotinamide as a therapeutic intervention for VL caused by Leishmania infantum in an experimental mouse model and investigated its underlying molecular mechanisms. The potential molecular mechanism was explored through cytokine analysis, examination of spleen lymphocyte subsets, liver RNA-seq analysis, and pathway validation. Results Compared to the infection group, the group treated with nicotinamide demonstrated significant amelioration of hepatosplenomegaly and recovery from liver pathological damage. The NAM group exhibited parasite reduction rates of 79.7% in the liver and 86.7% in the spleen, respectively. Nicotinamide treatment significantly reduced the activation of excessive immune response in infected mice, thereby mitigating hepatosplenomegaly and injury. Furthermore, nicotinamide treatment enhanced fatty acid β-oxidation by upregulating key enzymes to maintain lipid homeostasis. Conclusions Our findings provide initial evidence supporting the safety and therapeutic efficacy of nicotinamide in the treatment of Leishmania infection in BALB/c mice, suggesting its potential as a viable drug for VL. Graphical Abstract

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H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection

Cited by 3 publications

References 67 publications

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

LncRNA-H19 Promotes Adipogenic Differentiation Disorder by Regulating miR-130b-3p/PPARγ Axis in Steroid-induced Osteonecrosis of Femoral Head

Nicotinamide mitigates visceral leishmaniasis by regulating inflammatory response and enhancing lipid metabolism

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