H19 promotes aerobic glycolysis, proliferation, and immune escape of gastric cancer cells through the microRNA‐519d‐3p/lactate dehydrogenase A axis

Sun, Linqing; Li, Juntao; Yan, Wenying; Yao, Zhendong; Wang, Ruoqin; Zhou, Xiaojun; Wu, Hongya; Zhang, Guangbo; Shi, Tongguo; Chen, Weichang

doi:10.1111/cas.14896

Cited by 53 publications

(36 citation statements)

References 47 publications

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“…revealed that overexpression of H19 promotes immune escape of GC cells by modulating the activity of immune cells (γδT cells, Jurkat cells, and TAMs) via miR-519d-3p/LDHA axis. 134 Moreover, upregulation of SNHG15 is reported to increase the expression of PDL1 by targeting miR-141, thus facilitating the immune escape of GC cells. 135 In contrast to these oncogenic lncRNAs, some anti-tumoral lncRNAs show the opposite effect on the immune escape of GC cells.…”

Section: Roles Of Lncrnas In Gcmentioning

confidence: 99%

Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Liu

Ding

et al. 2021

Molecular Therapy - Oncolytics

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Gastric cancer (GC) is one of the most prevalent malignant tumor types and the third leading cause of cancer-related death worldwide. Its morbidity and mortality are very high due to a lack of understanding about its pathogenesis and the slow development of novel therapeutic strategies. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs with a length of more than 200 nt. They play crucial roles in a wide spectrum of physiological and pathological processes by regulating the expression of genes involved in proliferation, differentiation, apoptosis, cell cycle, invasion, metastasis, DNA damage, and carcinogenesis. The aberrant expression of lncRNAs has been found in various cancer types. A growing amount of evidence demonstrates that lncRNAs are involved in many aspects of GC pathogenesis, including its occurrence, metastasis, and recurrence, indicating their potential role as novel biomarkers in the diagnosis, prognosis, and therapeutic targets of GC. This review systematically summarizes the biogenesis, biological properties, and functions of lncRNAs and highlights their critical role and clinical significance in GC. This information may contribute to the development of better diagnostics and treatments for GC.

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Section: Roles Of Lncrnas In Gcmentioning

confidence: 99%

Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Liu

Ding

et al. 2021

Molecular Therapy - Oncolytics

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“… 5 For the Warburg effect, glucose is the substrate and lactate is the end product, thus, glucose consumption and lactate production could be used as parameters of aerobic glycolysis. 6 – 8 The Warburg effect not only furnishes cancer cells with ATP and anabolic precursors for macromolecules but also provides an acidic environment which could promote local invasion and proliferation of cancer cells. 9 , 10 Because of the important role of the Warburg effect in tumor growth and progression, hunting for the Warburg effect-related therapeutic targets has important value.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of DNMT3A Attenuates the Warburg Effect, Proliferation, and Invasion via Promoting the Inhibition of miR-603 on HK2 in Ovarian Cancer

Zhen

Tuo

et al. 2022

Technol Cancer Res Treat

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Background: Ovarian cancer is a highly malignant gynecological cancer. Aerobic glycolysis is one of the features of cancer cell metabolism. Studying the molecular modulation of the Warburg effect in ovarian cancer is significantly valuable for understanding the progression mechanism of ovarian cancer. Materials and Methods: The expression level and prognostic significance of DNMT3A were analyzed using public databases. DNMT3A was overexpressed by plasmid transfection, and DNMT3A was interfered with specific siRNAs transfection. miR-603 was overexpressed by mimic transfection or inhibited by inhibitor transfection. The expression of the molecules was detected by qPCR or western blotting. CCK-8 and transwell assays were used to determine the cell proliferation, migration, and invasion abilities of ovarian cancer. Results: We found that the DNMT3A protein level was higher in ovarian cancer tissues than in normal ovary tissues, but the mRNA level had no significant difference in ovarian cancer tissues and normal ovary tissues. The higher the RNA level of DNMT3A, the poorer prognosis of patients. DNMT3A knocking down impeded the Warburg effect, cell proliferation, migration, and invasion of ovarian cancer cells. Further investigations discovered that DNMT3A promoted ovarian cancer cell malignancy via silencing miR-603. Conclusion: We found that patients who overexpressed DNMT3A showed a poor prognosis. DNMT3A was found to promote the Warburg effect, cell proliferation, migration, and invasion of ovarian cancer by inhibiting the expression of miR-603. As a result, the research revealed that DNMT3A/miR-603/HK2 axis contributed to the Warburg effect of ovarian cancer and DNMT3A may be a potential therapeutic target for ovarian cancer.

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“…hsa-miR-519d-3p was predicted to target CDKN1A, HIF1A, MXD1 , and SOD2 , and its expression was significantly downregulated in COPD. Previous studies have reported that hsa-miR-519d-3p is involved in tumorigenesis in gastric cancer, pancreatic cancer, and lung cancer [ 52 – 54 ], and correlates with cell proliferation and migration in trophoblastic cell lines [ 55 ]. The biological function of hsa-miR-519d-3p in COPD is unknown.…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of aging-related genes in COPD based on bioinformatics analysis

Zhong

Yang

Liu

et al. 2022

Aging

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Chronic obstructive pulmonary disease (COPD) is a serious chronic respiratory disorder. One of the major risk factors for COPD progression is aging. Therefore, we investigated aging-related genes in COPD using bioinformatic analyses. Firstly, the Aging Atlas database containing 500 aging-related genes and the Gene Expression Omnibus database (GSE38974) were utilized to screen candidates. A total of 24 candidate genes were identified related to both COPD and aging. Using gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, we found that this list of 24 genes was enriched in genes associated with cytokine activity, cell apoptosis, NF-κB and IL-17 signaling. Four of these genes ( CDKN1A, HIF1A, MXD1 and SOD2 ) were determined to be significantly upregulated in clinical COPD samples and in cigarette smoke extract-exposed Beas-2B cells in vitro , and their expression was negatively correlated with predicted forced expiratory volume and forced vital capacity. In addition, the combination of expression levels of these four genes had a good discriminative ability for COPD patients (AUC = 0.794, 95% CI 0.743–0.845). All four were identified as target genes of hsa-miR-519d-3p, which was significantly down-regulated in COPD patients. The results from this study proposed that regulatory network of hsa-miR-519d-3p/ CDKN1A, HIF1A, MXD1, and SOD2 closely associated with the progression of COPD, which provides a theoretical basis to link aging effectors with COPD progression, and may suggest new diagnostic and therapeutic targets of this disease.

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H19 promotes aerobic glycolysis, proliferation, and immune escape of gastric cancer cells through the microRNA‐519d‐3p/lactate dehydrogenase A axis

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 53 publications

References 47 publications

Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Downregulation of DNMT3A Attenuates the Warburg Effect, Proliferation, and Invasion via Promoting the Inhibition of miR-603 on HK2 in Ovarian Cancer

Identification and validation of aging-related genes in COPD based on bioinformatics analysis

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