H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment

Abstract

In ARDS patients, with and without confirmed H1N1 influenza, prolonged low-to-moderate dose corticosteroid treatment was well tolerated and associated with significant improvement in lung injury and multiple organ dysfunction scores and a low hospital mortality. These findings provide the rationale for developing a randomized trial.

General Characteristics and Prognostic Factors of Pneumonia Cases DevelopedDuringPandemic(H1N1)Influenza-AVirus InfectioninTurkey

“…ARDS, multiple organ failure and mortality rate was high as expected among patients requiring ICU support. Therefore, mortality rate may differ in ICU patients and was reported to vary between 15% and 62.5% according to the centers (4,23,24). However, in some studies, the mortality rate of pandemic (H 1 N 1 ) influenza-A pneumonia cases not requiring ICU support did not differ from that of CAP with no H 1 N 1 infection (3,15).…”

Influenza A H1N1 pneumonia in a patient with hairy-cell leukemia

“…and a low dose of corticosteroid (prednisone 25 mg i.v. daily) [12,13]. The duration of antiviral, antibiotic and low dosage corticosteroid therapy was twelve days.…”

Hydrocortisone therapy for patients with H1N1 influenza A infection

“…There is insufficient evidence to support steroid administration for sepsis with shock, regardless of a patient's response to corticotropin testing [4]. Nevertheless, in Quispe-Laime and colleagues' work [1], 38% of patients did not have septic shock and 28.6% did not have severe ARDS. Why did the authors use steroids in these patients?…”

“…Dear editor: We read with interest Quispe-Laime and colleagues' work [1] which described the clinical presentation of 13 consecutive patients and their response to combination high-dose oseltamivir and prolonged low-to moderate dose corticosteroid treatment. A systematic review [2] suggested that prolonged low-dose corticosteroid therapy decreases mortality and recommended treating adult patients with vasopressor-dependent septic shock.…”