H1N1 influenza virus interaction with a porous layer of silicon nanowires

Abstract

Here, the non-specific interaction of the H1N1 influenza virus with a porous layer of silicon nanowires (PSi NWs) was studied by transmission and scanning electron microscopy (TEM, SEM, respectively) and optical spectroscopy. PSi NW layer with a thickness of about 200 nm was fabricated by metalassisted chemical etching of p-type highly doped crystalline silicon wafers, and consist of porous nanowires with a diameter of 50-200 nm, and a distance between the nanowires of 100-200 nm. It was shown that during the adsorption of viruses, viral particles with a diameter of about 100 nm bind to the porous surface of the nanowires. This interaction was revealed using TEM, SEM, and causes wavelength shifts in the Fabry-Perot fringes in the reflection spectrum of visible light from the PSi NW layer. The results show that thin layers of PSi NWs are a promising nanomaterial for creating filters and sensors for binding and detection of viruses.

Antiviral adsorption activity of porous silicon nanoparticles against different pathogenic human viruses

“…Previously we report that PSi NPs can act as efficient scavengers of human immunodeficiency virus (HIV) and respiratory syncytial virus (RSV): a strong suppression of the viral activity in the presence of PSi NPs have been revealed in vitro [ 28 ]. Also, the possibility of creating electrical and optical sensors based on PSi films for virus detection was shown earlier in works [ 29 , 30 ]. Thus, based on the unique structural and bio-properties of silicon nanoparticles, the study of their virucidal activity against pathogenic human viruses is of both scientific and applied interest.…”

Addressing the Theoretical and Experimental Aspects of Low-Dimensional-Materials-Based FET Immunosensors: A Review

“…The group led by Lieber at Harvard University demonstrated for the first time the use of SiNW-based FETs to sensing streptavidin in the picomolar range [5]. Since then, SiNW-FET-based immunosensors have been extensively explored to detect proteins [118], virus particles [119], and multiple protein biomarkers simultaneously [22,120].…”

Surface-Enhanced Raman Scattering from Dye Molecules in Silicon Nanowire Structures Decorated by Gold Nanoparticles

“…Silver (Ag) and gold (Au) NPs with amazing plasmonic characteristics are usually used to detect low concentrations of biomolecules by SERS [ 13 , 14 , 15 , 16 , 17 ]. While the SERS signal promoted by individual plasmonic NPs is characterized by relatively low intensity and poor reproducibility, which become a major obstacle for practical application and commercialization, the use of specifically designed nanostructured substrates as templates for plasmonic NPs is the main direction for the development of SERS sensing systems for different biomolecules [ 16 ], living cells [ 17 ], and biosystems [ 18 , 19 , 20 ].…”

“…In recent years, various types of semiconductor nanostructures such as silicon nanowires (SiNWs), nanotubes, and porous films have attracted research interest as templates for SERS-active plasmonic NPs because of the high surface-to-volume ratio, roughness, and the tunability of pore sizes in the former [ 19 , 20 , 21 , 22 , 23 ]. For example, SiNWs [ 22 ] and amorphous/crystalline hybrid Si-based nanostructures [ 23 ] have opened a broad avenue for developing new SERS substrates, which complement pure metallic nanostructures [ 2 , 3 , 6 ].…”