H2O2-responsive smart dressing for visible H2O2 monitoring and accelerating wound healing

Wu, Keke; Wu, Xiaoguang; Chen, Meng; Wu, Haoming; Jiao, Yanpeng; Zhou, Changren

doi:10.1016/j.cej.2020.124127

Cited by 68 publications

(43 citation statements)

References 70 publications

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“…In addition to the interaction between indicator molecules and dressing materials, the indicators can also be embedded into the interior of dressing materials to prevent leakage into the wound site. Wu et al [64] developed a H 2 O 2 -responsive smart wound dressing based on Europium(III) Coordination polymers (Eu CPs)-loaded polyacrylonitrile (PAN) nanofiber mates by electrospinning technique (Figure 3b). The smart dressing could detect the amount of H 2 O 2 in both in vitro and in vivo wound models through fluorescence changes in ultraviolet (UV) irradiation; the H 2 O 2 concentrations have a linear relationship with fluorescence intensity over the range of 20-200 × 10 −6 m, which overlays the safe threshold for H 2 O 2 concentration (<100 × 10 −6 m).…”

Section: Optical Detection Approachesmentioning

confidence: 99%

“…Reproduced with permission. [64] Copyright 2020, Elsevier. c) The fabrication process and temperature sensing performance of flexible and breathable on-skin devices, featuring temperature triggered drug release ability.…”

Section: Electrical Detection Approachesmentioning

confidence: 99%

mentioning

confidence: 99%

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Multifunctional Dressing for Wound Diagnosis and Rehabilitation

Tang

Zheng

Cui

et al. 2021

Adv Healthcare Materials

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A wound dressing is a sterile pad or compress that is used in direct contact with a wound to help it heal and prevent further issues or complications. Though wound healing is an intricate dynamic process that involves multiple biomolecular species, conventional wound dressings have a limited ability to provide timely information of abnormal conditions, missing the best time for early treatment. The current perspective presents and discusses the design and development of smart wound dressings that are integrated with multifunctional materials, wearable sensors and drug delivery systems as well as their application ranging from wound monitoring to timely application of therapeutics. The perspective also discusses the ongoing challenges and exciting opportunities associated with the development of wearable sensor-based smart wound dressing and provide critical insights into wound healing monitoring and management.

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Section: Optical Detection Approachesmentioning

confidence: 99%

Section: Electrical Detection Approachesmentioning

confidence: 99%

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Multifunctional Dressing for Wound Diagnosis and Rehabilitation

Tang

Zheng

Cui

et al. 2021

Adv Healthcare Materials

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“…It was indicated that the HAP/SN-NR can powerfully enhance tissue regeneration by the mean of activating the ) with various reported wound materials. Compared to T 1/2 of silver nanoparticles (Ag NPs)/drug/Chitosan (CS)/Salicylaldehyde (SA) coating, [43] polydopamine (PDA)-silk fibroin film, [44] Chitosan/polyvinyl pyrrolidone (PVP)/ Nanostarch film, [45] polyurethane (PU) foam-film, [46] polyacrylamide (PAAm)-Dopa hydrogel, [47] Alginate-gelatin hydrogel, [48] and polyacrylonitrile (PAN)-Europium(III) Coordination Polymers (Eu CPs) nanofiber mat, [49] HAP/SN-NR as the dressing can shorten the wound healing time. e) The wound closure rate of rats in the above groups.…”

Section: Study On Factors Of Pro-healing Wound In Vivo By Hap/sn-nrmentioning

confidence: 99%

Biomechanical Motion‐Activated Endogenous Wound Healing through LBL Self‐Powered Nanocomposite Repairer with pH‐Responsive Anti‐Inflammatory Effect

Yuan

Yang

Fan

et al. 2021

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“…Electrospun hybrid polyacrilonitrile (PAN) nanofiber mats have been developed for wound healing, possessing the ability to monitor in real-time the H 2 O 2 level in the wound [191]. High H 2 O 2 concentration in wounds leads to delayed healing, hindering connective tissue formation [192].…”

Section: Smart Nanomaterialsmentioning

confidence: 99%

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

2020

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Bacterial infections occur when wound healing fails to reach the final stage of healing, which is usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site, which is accompanied very often by increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases. AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies that are used to combat infection and modulate the healing rate—such as polymers, scaffolds, films and wound dressings, and organic and inorganic nanoparticles—have been discussed as well. New technologies such as Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated protein (CRISPR-Cas) are taken into consideration as potential future tools for AMP delivery in skin therapy.

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H2O2-responsive smart dressing for visible H2O2 monitoring and accelerating wound healing

Cited by 68 publications

References 70 publications

Multifunctional Dressing for Wound Diagnosis and Rehabilitation

Multifunctional Dressing for Wound Diagnosis and Rehabilitation

Biomechanical Motion‐Activated Endogenous Wound Healing through LBL Self‐Powered Nanocomposite Repairer with pH‐Responsive Anti‐Inflammatory Effect

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

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