H2S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury via CBS, CSE, and TST Expression

Pavlovskiy, Yaroslav; Yashchenko, А. М.; Zayachkivska, Оksana

doi:10.3389/fphar.2020.01134

Cited by 12 publications

(6 citation statements)

References 51 publications

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“…Decreased activation of H 2 S signaling in the HFD model is associated with the increase in mitochondrial impairment and oxidative stress that stimulates the expression of thiosulfate-dithiol sulfurtransferase. The gastro-protection observed upon ATB-340 treatment is H 2 S-dependent and is related to the attenuation of oxidative stress [ 243 ].…”

Section: H 2 S Donors and Diseasesmentioning

confidence: 99%

H2S Donors and Their Use in Medicinal Chemistry

Magli¹,

Perissutti²,

Santagada³

et al. 2021

Biomolecules

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Hydrogen sulfide (H2S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H2S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H2S levels has a potential therapeutic value. Consequently, synthetic H2S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H2S donors; furthermore, herein we discuss their preparation, the H2S-releasing mechanisms, and their -biological applications.

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Section: H 2 S Donors and Diseasesmentioning

confidence: 99%

H2S Donors and Their Use in Medicinal Chemistry

Magli¹,

Perissutti²,

Santagada³

et al. 2021

Biomolecules

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“…1 ATB-340 is a H 2 S-releasing derivative of low-dose aspirin without the serious risk of gastrointestinal bleeding. Pre-clinical studies have demonstrated that ATB-340 caused negligible GI damage compared to low-dose aspirin ( 139 ). ATB 346, which is derived from the NSAID naproxen, was recently shown in a Phase 2B study to reduce GI toxicity compared to naproxen alone, with equivalent suppression of COX activity ( 140 ).…”

Section: Discussion: New Perspectives For the Treatment Of Intimal Hp...mentioning

confidence: 99%

Clinical Use of Hydrogen Sulfide to Protect Against Intimal Hyperplasia

Macabrey

Longchamp

Déglise

et al. 2022

Front. Cardiovasc. Med.

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Arterial occlusive disease is the narrowing of the arteries via atherosclerotic plaque buildup. The major risk factors for arterial occlusive disease are age, high levels of cholesterol and triglycerides, diabetes, high blood pressure, and smoking. Arterial occlusive disease is the leading cause of death in Western countries. Patients who suffer from arterial occlusive disease develop peripheral arterial disease (PAD) when the narrowing affects limbs, stroke when the narrowing affects carotid arteries, and heart disease when the narrowing affects coronary arteries. When lifestyle interventions (exercise, diet…) fail, the only solution remains surgical endovascular and open revascularization. Unfortunately, these surgeries still suffer from high failure rates due to re-occlusive vascular wall adaptations, which is largely due to intimal hyperplasia (IH). IH develops in response to vessel injury, leading to inflammation, vascular smooth muscle cells dedifferentiation, migration, proliferation and secretion of extra-cellular matrix into the vessel’s innermost layer or intima. Re-occlusive IH lesions result in costly and complex recurrent end-organ ischemia, and often lead to loss of limb, brain function, or life. Despite decades of IH research, limited therapies are currently available. Hydrogen sulfide (H2S) is an endogenous gasotransmitter derived from cysteine metabolism. Although environmental exposure to exogenous high H2S is toxic, endogenous H2S has important vasorelaxant, cytoprotective and anti-inflammatory properties. Its vasculo-protective properties have attracted a remarkable amount of attention, especially its ability to inhibit IH. This review summarizes IH pathophysiology and treatment, and provides an overview of the potential clinical role of H2S to prevent IH and restenosis.

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“…Overall, external stress enhances H 2 S-related enzyme activity, such as TST [ 200 ]. However, Kruger et al observed a reduced expression and translation of TST with a high production of superoxide in the mitochondria of monocytes, which could predict mortality [ 201 ].…”

Section: Sulfurtransferasesmentioning

confidence: 99%

Sulfur Administration in Fe–S Cluster Homeostasis

2021

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Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters. The newly formed cluster can be utilized by mitochondrial Fe–S protein synthesis or undergo further transformation. Mitochondrial Fe–S cluster biogenesis components are required in the cytosolic iron–sulfur cluster assembly machinery for cytosolic and nuclear cluster supplies. Clusters that are the key components of Fe–S proteins are vulnerable and prone to degradation whenever exposed to oxidative stress. However, once degraded, the Fe–S cluster can be resynthesized or repaired. It has been proposed that sulfurtransferases, rhodanese, and 3-mercaptopyruvate sulfurtransferase, responsible for sulfur transfer from donor to nucleophilic acceptor, are involved in the Fe–S cluster formation, maturation, or reconstitution. In the present paper, we attempt to sum up our knowledge on the involvement of sulfurtransferases not only in sulfur administration but also in the Fe–S cluster formation in mammals and yeasts, and on reconstitution-damaged cluster or restoration of enzyme’s attenuated activity.

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H2S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury via CBS, CSE, and TST Expression

Cited by 12 publications

References 51 publications

H2S Donors and Their Use in Medicinal Chemistry

H2S Donors and Their Use in Medicinal Chemistry

Clinical Use of Hydrogen Sulfide to Protect Against Intimal Hyperplasia

Sulfur Administration in Fe–S Cluster Homeostasis

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