2019
DOI: 10.3390/genes10020093
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H3K9 Promotes Under-Replication of Pericentromeric Heterochromatin in Drosophila Salivary Gland Polytene Chromosomes

Abstract: Chromatin structure and its organization contributes to the proper regulation and timing of DNA replication. Yet, the precise mechanism by which chromatin contributes to DNA replication remains incompletely understood. This is particularly true for cell types that rely on polyploidization as a developmental strategy for growth and high biosynthetic capacity. During Drosophila larval development, cells of the salivary gland undergo endoreplication, repetitive rounds of DNA synthesis without intervening cell div… Show more

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Cited by 15 publications
(10 citation statements)
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“…SUUR still localizes to these PH regions, but is unable to inhibit fork progression and promote UR because Rif1 is not present and SUUR is unable to inhibit fork progression in the absence of Rif1 (Munden et al, 2018). This model is in agreement with multiple observations indicating that SUUR binding to euchromatic and pericentric heterochromatin is different and that the genetic requirements for UR in euchromatin and pericentric heterochromatin are unique (Armstrong et al, 2019;Guarner et al, 2017).…”
Section: Discussionsupporting
confidence: 89%
“…SUUR still localizes to these PH regions, but is unable to inhibit fork progression and promote UR because Rif1 is not present and SUUR is unable to inhibit fork progression in the absence of Rif1 (Munden et al, 2018). This model is in agreement with multiple observations indicating that SUUR binding to euchromatic and pericentric heterochromatin is different and that the genetic requirements for UR in euchromatin and pericentric heterochromatin are unique (Armstrong et al, 2019;Guarner et al, 2017).…”
Section: Discussionsupporting
confidence: 89%
“…The intercalary heterochromatin regions correspond to extended domains of tissue-specific genes, that is, they are represented by unique rather than repeated sequences [ 14 , 26 ]. This finding made it possible to obtain detailed underreplication profiles of these areas [ 6 , 26 , 27 , 32 , 33 ]. The presence of intercalary heterochromatin regions leads to approximately ≤19% DNA underrepresentation in euchromatic polytene chromosome arms [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…When histone H1 is knocked down, underreplication suppression is also observed in some pericentromeric heterochromatin areas [ 32 ]. H3K9 di-/tri-methylation and histone methyltransferase Su(VAR)3-9 affect underreplication of some heterochromatin sequences [ 33 , 60 , 62 ]. None of these factors has a significant effect on satellite DNA polytenization.…”
Section: Introductionmentioning
confidence: 99%
“…Typically found in specialty tissues of Diptera, such as the well-studied polyploid salivary gland and ovarian follicle cells, UR results from a coupling of protein products from Rif1 and SuUR hindering progression of the DNA replication fork [3,4]. This stall usually occurs upon encountering heterochromatic DNA, which is tightly wound into nucleosomes, preventing this heterochromatic DNA from fully replicating [5,6]. While recent work has investigated the machinery involved in this stalling of replication, the mechanisms behind this process are not fully understood [2,7,8].…”
Section: Introductionmentioning
confidence: 99%