Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus

Brown, Paul; Palacorolla, Heather; Brady, Dana; Riegger, Katelyn E.; Elmer, Gregory I.; Shepard, Paul D.

doi:10.1523/jneurosci.1353-16.2016

Cited by 64 publications

(41 citation statements)

References 56 publications

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“…It has been shown that stimulation of the RMTg inhibits both the VTA and the SNc (Hong et al 2011;Bourdy et al 2014;Lecca et al 2012), and RMTg inhibition increased DA neurons activity (Jalabert et al 2011). Recently, Brown and collaborators have shown that RMTg neurons contribute directly to the LHb-induced inhibition of DA neurons activity (Brown et al 2017). The RMTg receives afferents from a wide range of cerebral structures (for review see (Bourdy and Barrot 2012)) such as the cortex, the periaqueducal gray, the LDTg and PPTg, suggesting that the RMTg may integrate a variety of information that can modulate activity of both the VTA and SNc.…”

Section: Addiction and The Addiction Cyclementioning

confidence: 99%

Dopamine and addiction: what have we learned from 40 years of research

et al. 2018

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Among the neurotransmitters involved in addiction, dopamine (DA) is clearly the best known. The critical role of DA in addiction is supported by converging evidence that has been accumulated in the last forty years. In the present review, firstly we describe the dopaminergic system in terms of connectivity, functioning and involvement in reward processes. Secondly, we describe the functional, structural, and molecular changes induced by drugs within the DA system in terms of neuronal activity, synaptic plasticity and transcriptional and molecular adaptations. Thirdly, we describe how genetic mouse models have helped characterizing the role of DA in addiction. Fourthly, we describe the involvement of the DA system in the vulnerability to addiction and the interesting case of addiction DA replacement therapy in Parkinson's disease. Finally, we describe how the DA system has been targeted to treat patients suffering from addiction and the result obtained in clinical settings and we discuss how these different lines of evidence have been instrumental in shaping our understanding of the physiopathology of drug addiction.

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Section: Addiction and The Addiction Cyclementioning

confidence: 99%

Dopamine and addiction: what have we learned from 40 years of research

et al. 2018

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“…Called the ‘tail of the VTA’ by one group (Perrotti et al, 2005, Kaufling et al, 2009), these neurons are now better known as the rostromedial tegmental nucleus (RMTg; Jhou et al, 2009a; b). The timely discovery of the RMTg provides an explanation as to how activation of LHb neurons by aversive stimuli (Christoph et al, 1986; Ullsperger and von Cramon, 2003; Brown et al, 2017) elicits profound inhibition of VTA DA neurons (Ji and Shephard, 2007; Shepard et al, 2006; Matsumoto and Hikosaka, 2007). The opposing valences of LHb and VTA/SNc responses to reward omission and aversive stimuli previously had been difficult to reconcile because the axonal projection from the LHb to the VTA is almost exclusively excitatory (Geisler et al, 2007; Brinschwitz et al, 2010), which dictated a need for an inhibitory intermediary – the RMTg, it turned out - to account for the functional findings (see the discussion in Ji and Shephard, 2007).…”

Section: Efferent Connectionsmentioning

confidence: 99%

Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving

Zahm

Root

2017

Pharmacology Biochemistry and Behavior

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The cytology and connections of the lateral habenula (LHb) are reviewed. The habenula is first introduced, after which the cytology of the LHb is discussed mainly with reference to cell types, general topography and descriptions of subnuclei. An overview of LHb afferent connections is given followed by some details about the projections to LHb from a number of structures. An overview of lateral habenula efferent connections is given followed by some details about the projections from LHb to a number of structures. In considering the afferent and efferent connections of the LHb some attention is given to the relative validity of regarding it as a bi-partite structure featuring ‘limbic’ and ‘pallidal’ parts. The paper ends with some concluding remarks about the relative place of the LHb in adaptive behaving.

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“…Golden et al used a place preference conditioning paradigm to demonstrate the rewarding value of winning: after aggressive mice attacked and subordinated an intruder, they developed a preference for the intruder-paired chamber. When the LHb was artificially activated by optogenetically silencing an inhibitory input to the LHb, the rewarding effect of winning was blocked [67]. Thus, reducing activity of the LHb which presumably increasing activity of VTA dopamine neurons is essential for the rewarding effect of winning.…”

Section: Mesolimbic Dopamine Control Of Aggressive Behaviorsmentioning

confidence: 99%

Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression

Yamaguchi

Lin

2018

Current Opinion in Behavioral Sciences

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Aggression is a crucial survival behavior: it is employed to defend territory, compete for food and mating opportunities, protect kin, and resolve disputes. Although widely differing in its behavioral expression, aggression is observed across many species. The neural substrates of aggression have been investigated for nearly a century and two highly conserved circuitries emerge as critical substrates for generating and modulating aggression. One circuitry centers on the medial hypothalamus. Activity of the medial hypothalamic cells closely correlates with attacks and can bi-directionally modulate aggressive behaviors. The other aggression-related circuit involves the mesolimbic dopamine cells. Dopaminergic antagonists are the most commonly used treatment for suppressing human aggression in psychotic patients. Animal studies support essential roles of dopaminergic signaling in the nucleus accumbens in assessing the reward value of aggression and reinforcing the aggressive behaviors. In this review, we will provide an overview regarding the functions of medial hypothalamus and dopaminergic system in mediating aggressive behaviors and the potential interactions between these two circuitries.

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Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus

Cited by 64 publications

References 56 publications

Dopamine and addiction: what have we learned from 40 years of research

Dopamine and addiction: what have we learned from 40 years of research

Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving

Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression

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