Habenula-prefrontal resting-state connectivity in reactive aggressive men – A pilot study

Gan, Gabriela; Zilverstand, Anna; Parvaz, Muhammad A.; Preston-Campbell, Rebecca N.; Uquillas, Federico d’Oleire; Moeller, Scott J.; Tomasi, Dardo; Goldstein, Rita Z.; Alia‐Klein, Nelly

doi:10.1016/j.neuropharm.2018.10.025

Cited by 20 publications

(15 citation statements)

References 98 publications

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“…Although not a direct assay of aggression motivation, in combination with the previously results, these findings support the role of the habenular complex in controlling aggression-related social behaviors. Similarly, in a preliminary pilot study of men diagnosed with severe intermittent-explosive disorder, resting-state fMRI results suggest that high levels of trait aggression are linked to lower global efficiency of the left habenula (Gan et al, 2018). Additionally, lower resting-state functional connectivity was observed between the left habenula and the left ventrolateral PFC, a region involved in inhibitory control.…”

Section: Neuroanatomical Mechanismsmentioning

confidence: 86%

Animal Models of (or for) Aggression Reward, Addiction, and Relapse: Behavior and Circuits

2019

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Inappropriate and pathological aggression plays a leading role in the suffering and death of millions of people, and further places an untenable strain on the caregivers and families of those afflicted. In some cases, such as addictive drugs, aggression can be highly rewarding (appetitive) and continually pursued despite short-and long-term negative consequences. Similarly, recidivism (relapse) rates for repeat violent offenders are as high as relapse rates for drug addicts. Appetitive aggression and relapse to aggression seeking can be modeled in mice studies using conditioned place preference and self-administration procedures followed by a period of abstinence and subsequent tests for relapse to aggression preference and aggression seeking. These procedures allow for the study of the mechanisms that control the appetitive versus the consummatory (attack) phases of aggressive behavior. In this review, we first discuss the behavioral procedures developed to probe appetitive aggression in mouse models, spanning from Pavlovian to operant tasks, and we also describe the recently proposed phenomenon of "aggression addiction." Next, we discuss the pharmacological and circuit mechanisms of aggression conditioned place preference and aggression self-administration, seeking, and relapse, highlighting mechanistic congruence and divergence between appetitive and consummatory phases of aggression. We conclude by discussing clinical implications of the studies reviewed.

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Section: Neuroanatomical Mechanismsmentioning

confidence: 86%

Animal Models of (or for) Aggression Reward, Addiction, and Relapse: Behavior and Circuits

2019

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“…The habenula has been implicated in aggressive behaviors in rodents and fish ( Chou et al, 2016 ; Flanigan et al, 2017 ; Webster and Wozny, 2020 ). A functional magnetic resonance imaging in male patients with the symptom of intermittent explosive disorder (IED) shows a possible association between the habenula activity and the severity of aggressive behavior ( Gan et al, 2019 ). However, based on animal studies, the habenula is unlikely to regulate the expression of aggressive behavior since the induction of c-fos in the habenula of aggressive animals was not extensive ( Delville et al, 2000 ).…”

Section: Role Of the Habenula In Social Behaviorsmentioning

confidence: 99%

Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals

Ogawa

Parhar

2022

Front. Behav. Neurosci.

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Social behaviors such as mating, parenting, fighting, and avoiding are essential functions as a communication tool in social animals, and are critical for the survival of individuals and species. Social behaviors are controlled by a complex circuitry that comprises several key social brain regions, which is called the social behavior network (SBN). The SBN further integrates social information with external and internal factors to select appropriate behavioral responses to social circumstances, called social decision-making. The social decision-making network (SDMN) and SBN are structurally, neurochemically and functionally conserved in vertebrates. The social decision-making process is also closely influenced by emotional assessment. The habenula has recently been recognized as a crucial center for emotion-associated adaptation behaviors. Here we review the potential role of the habenula in social function with a special emphasis on fish studies. Further, based on evolutional, molecular, morphological, and behavioral perspectives, we discuss the crucial role of the habenula in the vertebrate SDMN.

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“…The LHb is often ignored in neurostructural research due to the technical challenge of resolving its structure because of its small size and deep position within the brain. However, advances in both the power of, and analytical approaches to, resolving fMRI signaling now provide satisfactory resolution for LHb registration and segmentation (Gan et al, 2019 ; Hashikawa et al, 2020 ).…”

Section: The Lateral Habenula Suicidal Ideation Suicidal Behavior And...mentioning

confidence: 99%

The Role of the Lateral Habenula in Suicide: A Call for Further Exploration

Marks

Wee

Jacobson

et al. 2022

Front. Behav. Neurosci.

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Despite decades of significant effort in research, policy, and prevention, suicide rates have continued to rise to the current peak of 14.6 per 100,000 deaths. This has resulted in a concerted effort to identify biomarkers associated with suicidal behavior in the brain, to provide predictions that are better than the chance of discerning who will die by suicide. We propose that the lateral habenula (LHb), and its dysfunction during a suicidal crisis, is a critical component of the transition from suicidal ideations to self-harm. Moreover, the LHb—a key functional node in brain reward circuitry—has not been ascribed a contributory role in suicidal behavior. We argue that the LHb anchors a “suicide circuit” and call for suicide researchers to directly examine the role of the LHb, and its long-term modulation, in response to the negative affect in suicidal behavior. Discerning the neural mechanisms of this contribution will require the collaboration of neuroscientists and psychologists. Consequently, we highlight and discuss research on LHb as it relates to suicidal ideation, suicidal behavior, or death by suicide. In so doing we hope to address the bench-to-bedside translational issues currently involved in suicide research and suggest a developmental framework that focuses on specific structures motivated by theoretical anchors as a way to incorporate neurobiological findings within the context of clinical theory.

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Habenula-prefrontal resting-state connectivity in reactive aggressive men – A pilot study

Cited by 20 publications

References 98 publications

Animal Models of (or for) Aggression Reward, Addiction, and Relapse: Behavior and Circuits

Animal Models of (or for) Aggression Reward, Addiction, and Relapse: Behavior and Circuits

Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals

The Role of the Lateral Habenula in Suicide: A Call for Further Exploration

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