Habituation: Events in the history of its characterization and linkage to synaptic depression. A new proposed kinetic criterion for its identification

Christoffersen, G.R.J.

doi:10.1016/s0301-0082(97)00031-2

Cited by 85 publications

(71 citation statements)

References 92 publications

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“…The results of Experiment 1, which examined HPA axis hormones (CORT and ACTH), support the hypothesis that massed exposure to stress stimuli produces weaker and less durable habituation compared with a more spaced exposure regimen, as reported in a number of studies of behavioral response habituation (see Christoffersen, 1997, for a review). There were some treatment differences, however, between the spaced and massed groups of Experiment 1 that may have led to the observed differences.…”

Section: Discussionsupporting

confidence: 77%

Long-term habituation to repeated loud noise is impaired by relatively short interstressor intervals in rats.

Masini¹,

Day²,

Campeau³

2008

Behavioral Neuroscience

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The phenomenon of spaced (longer intertrial interval) compared with massed (shorter intertrial interval) training leading to better long-term habituation and associative learning is well documented. However, the effects of intertrial intervals on response habituation to repeated stress exposures have not been previously examined. The present experiments found that massed (six 30-min exposures of 95 dB white noise in 6 hr) and spaced (one 30-min exposure daily for 6 days) noise exposures led to similar habituation of plasma corticosterone and ACTH responses, heart rate, and core body temperature after the 6th exposure in male Sprague-Dawley rats. However, these habituated responses were not retained in the massed group on a similar noise re-exposure 48 hr later, compared with the spaced group. The habituated responses found in the massed group after the 6 noise exposures were not due to differential hearing threshold shifts, as examined with modifications of the acoustic startle reflex. These data indicate that relatively short interstressor intervals impair long-term stress adaptation. This series of studies supports the idea of distinct short-and long-term habituation processes to stress responsiveness.

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Section: Discussionsupporting

confidence: 77%

Long-term habituation to repeated loud noise is impaired by relatively short interstressor intervals in rats.

Masini¹,

Day²,

Campeau³

2008

Behavioral Neuroscience

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“…Habituation is a reduction over time of the amplitude of the ASR, seen after repeated presentation of identical startle eliciting pulses, which is not a result of sensory adaptation or muscle fatigue, and is considered a form of non-associative learning (Christoffersen, 1997). Patients with schizophrenia have frequently been found to show disrupted PPI, when compared with healthy controls (eg Braff et al, 1978Braff et al, , 1992Kumari et al, 2000;Parwani et al, 2000;Mackeprang et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Increased Central Serotonergic Activity on Prepulse Inhibition and Habituation of the Human Startle Response

Jensen

Oranje

Wienberg

et al. 2007

Neuropsychopharmacol

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Sensorimotor gating is critical to normal brain functioning, and disruptions are associated with certain mental illnesses, such as schizophrenia. Prepulse inhibition of the acoustic startle reflex (ASR) (PPI) is an operational measure of sensorimotor gating, of which evidence for a serotonergic modulation is currently inconsistent. In a double-blind placebo-controlled crossover design, 18 healthy male volunteers received either placebo or a dose of 10 mg of escitalopram (SSRI), after which they were tested in both PPI and habituation of the startle reflex paradigms. No significant differences between the two treatments were observed on PPI, although escitalopram was found to significantly delay habituation of the ASR. In the current study, escitalopram was found to delay habituation, but it did not affect PPI in healthy male volunteers. As escitalopram is a highly specific SSRI, the results suggest that an increased serotonergic activity disrupts habituation, but not PPI in healthy volunteers.

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“…Adaptation to sensory stimulation and resulting behavioral habituation is one such mechanism that allows filtering of more static, behaviorally less relevant stimuli (Thompson and Spencer, 1966;Christoffersen, 1997). The neural mechanisms of sensory habituation have been determined in several invertebrate models (Zucker, 1972;Kandel and Schwartz, 1982;Christoffersen, 1997) but have been more elusive in the mammalian brain.…”

Section: Introductionmentioning

confidence: 99%

Cortical Metabotropic Glutamate Receptors Contribute to Habituation of a Simple Odor-Evoked Behavior

Best¹,

Thompson²,

Fletcher³

et al. 2005

J. Neurosci.

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Defining the circuits that are involved in production and cessation of specific behaviors is an ultimate goal of neuroscience. Short-term behavioral habituation is the response decrement observed in many behaviors that occurs during repeated presentation of nonreinforced stimuli. Within a number of invertebrate models of short-term behavioral habituation, depression of a defined synapse has been implicated as the mechanism. However, the synaptic mechanisms of short-term behavioral habituation have not been identified within mammals. We have shown previously that a presynaptic metabotropic glutamate receptor (mGluR)-dependent depression of synapses formed by olfactory bulb afferents to the piriform (olfactory) cortex significantly contributes to adaptation of cortical odor responses. Here we show that blockade of mGluRs within the olfactory cortex of awake, behaving rats diminishes habituation of a simple odor-induced behavior, strongly implicating a central mechanism for sensory gating in olfaction.

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Habituation: Events in the history of its characterization and linkage to synaptic depression. A new proposed kinetic criterion for its identification

Cited by 85 publications

References 92 publications

Long-term habituation to repeated loud noise is impaired by relatively short interstressor intervals in rats.

Long-term habituation to repeated loud noise is impaired by relatively short interstressor intervals in rats.

The Effects of Increased Central Serotonergic Activity on Prepulse Inhibition and Habituation of the Human Startle Response

Cortical Metabotropic Glutamate Receptors Contribute to Habituation of a Simple Odor-Evoked Behavior

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