Hadrontherapy: An open source, Geant4-based application for proton-ion therapy studies

Cirrone, G.A.P.; Cuttone, G.; Rosa, F. Di; Mazzaglia, S.; Romano, F.; Attili, A.; Bourhaleb, F.; Russo, G.; Kataniemi, Pekka; Heikkinen, A.; Marchetto, F.; Shin, J

doi:10.1109/nssmic.2009.5402279

Cited by 13 publications

(12 citation statements)

References 6 publications

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“…The largest part of simulations for this manuscript was performed on a modified version of G4beamline (to make the output data format compatible with the GA code) without space charge effects. The beam propagation simulated using G4beamline showed perfect agreement with results obtained using the Hadrontherapy Geant4-based tool [31,32]. Also, the beam propagation simulated with both tools proved to be consistent with EBT3 recorded profiles [24].…”

Section: Application To a Laser-accelerated Proton Beamsupporting

confidence: 69%

Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm

2019

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A B S T R A C TLaser-accelerated protons have a great potential for innovative experiments in radiation biology due to the subpicosecond pulse duration and high dose rate achievable. However, the broad angular divergence makes them not optimal for applications with stringent requirements on dose homogeneity and total flux at the irradiated target. The strategy otherwise adopted to increase the homogeneity is to increase the distance between the source and the irradiation plane or to spread the beam with flat scattering systems or through the transport system itself. Such methods considerably reduce the proton flux and are not optimal for laser-accelerated protons. In this paper we demonstrate the use of a Genetic Algorithm (GA) to design an optimal non-flat scattering system to shape the beam and efficiently flatten the transversal dose distribution at the irradiated target. The system is placed in the magnetic transport system to take advantage of the presence of chromatic focusing elements to further mix the proton trajectories. The effect of a flat scattering system placed after the transport system is also presented for comparison. The general structure of the GA and its application to the shaping of a laser-accelerated proton beam are presented, as well as its application to the optimisation of dose distribution in a water target in air.

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Section: Application To a Laser-accelerated Proton Beamsupporting

confidence: 69%

Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm

2019

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“…For example, Paganetti et al 110,111 used GEANT4 V5.2 to model and validate the treatment nozzle of the Northeast Proton Therapy Centre (NPTC), including an explicit model of the temporal variation of the beam energy by the range modulator wheel. 112 Since 2004, an official hadrontherapy GEANT4 example is also available with the source code, 113 describing the 62 MeV proton therapy beam line of the CATANA facility (Centro di AdroTerapia e Applicazioni Nucleari Avanzate). GEANT4 is also used in the VMCpro code dedicated to treatment planning in proton beam therapy.…”

Section: E Particle Therapymentioning

confidence: 99%

A review of the use and potential of the GATE Monte Carlo simulation code for radiation therapy and dosimetry applications

Sarrut¹,

Bardiès²,

Boussion³

et al. 2014

Med. Phys.

386

263

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In this paper, the authors' review the applicability of the open-source GATE Monte Carlo simulation platform based on the GEANT4 toolkit for radiation therapy and dosimetry applications. The many applications of GATE for state-of-the-art radiotherapy simulations are described including external beam radiotherapy, brachytherapy, intraoperative radiotherapy, hadrontherapy, molecular radiotherapy, and in vivo dose monitoring. Investigations that have been performed using GEANT4 only are also mentioned to illustrate the potential of GATE. The very practical feature of GATE making it easy to model both a treatment and an imaging acquisition within the same framework is emphasized. The computational times associated with several applications are provided to illustrate the practical feasibility of the simulations using current computing facilities.

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“…Geant4 includes a series of packages for the simulation of electromagnetic and hadronic interactions of particles with matter, specialised for different particle types, energy range or approach in physics modelling. The variety of physics approaches provided contributes to Geant4 versatility for application in many different experimental domains, for instance, hadron therapy (Cirrone et al 2009, Lechner et al 2010, medical tomography (Apostolakis 2008), space radiation environment (Ersmark et al 2007), and others (Allison et al 2006). The simulation of interactions of hadrons and ions with atomic nuclei is a significant part of the toolkit used in a majority of Geant4 applications.…”

Section: Introductionmentioning

confidence: 99%

Geant4 hadronic physics for space radiation environment

Ivantchenko

Ivanchenko

Molina

et al. 2011

International Journal of Radiation Biology

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Hadrontherapy: An open source, Geant4-based application for proton-ion therapy studies

Cited by 13 publications

References 6 publications

Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm

Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm

A review of the use and potential of the GATE Monte Carlo simulation code for radiation therapy and dosimetry applications

Geant4 hadronic physics for space radiation environment

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