Haemato-Biochemical Alterations in Dogs Affected  with Superficial Pyoderma

Khinchi, R.K.; Sharma, S.K.; Goklaney, Deepika; Morwal, Sandhya; ju, Man

doi:10.20546/ijcmas.2019.805.203

Cited by 1 publication

(2 citation statements)

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“…The increased concentrations of BUN and creatinine may be due to dehydration caused by the hemorrhagic conditions revealed from pyoderma lesions, whereas the increased levels of AST and ALT may be related to increased levels of inflammatory cytokines, as reported in a previous study by our group [13]. Serum glucose concentrations were lower in the experimentally infected dogs compared with those of negative control dogs; these findings are in line with those previously documented in dogs [21]. Biochemical profiles revealed in the positive control group , making our results generally consistent with those of a previous study of dogs with atopic dermatitis [23].…”

Section: Discussionsupporting

confidence: 91%

“…In the present study, the indicators of liver function (i.e., AST and ALT levels) and kidney function (e.g., BUN and creatinine) were higher in dogs experimentally infected with pyoderma; our results are similar to those reported for dogs with pyoderma and dermatophytosis [20] but disagree with the results of other studies [21,22]. The increased concentrations of BUN and creatinine may be due to dehydration caused by the hemorrhagic conditions revealed from pyoderma lesions, whereas the increased levels of AST and ALT may be related to increased levels of inflammatory cytokines, as reported in a previous study by our group [13].…”

Section: Discussioncontrasting

confidence: 89%

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Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyoderma

et al. 2021

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Background and Aim: Pyoderma is common in dogs, and its treatment requires a novel medication rather than antibiotic therapy. This study aimed to determine the biochemical and histopathological changes associated with the topical application of Aloe vera 20% and 40% ointments, compared with gentamicin 0.1% ointment, in dogs suffering from Staphylococcus aureus pyoderma. Materials and Methods: Serum and skin samples were collected from a negative control group before inducing pyoderma and from other subdivided groups on the 3rd, 7th, 10th, and 14th days post-inoculation for biochemical and histopathology examination. Results: Serum aspartate aminotransferase, alanine aminotransferase (ALT), urea, and creatinine concentrations were higher in the positive control dogs on the 3rd day without treatment (DWT) compared with the negative control dogs (p<0.05). Compared with the healthy control dogs, serum zinc concentrations were lower in the positive control group on the 3rd, 7th, and 10th DWT and in dogs treated with A. vera 20% and gentamicin 0.1% ointments on the 3rd and 7th days post-treatment (p<0.05). Grossly, skin had erythema, pruritus, and pus-filled pustules of the untreated group. Microscopically, skin showed epidermal necrosis and edema, dermal collagen necrosis, and severe neutrophilic infiltration. Conclusion: Compared with A. vera 20% and gentamicin 0.1% ointments, the topical application of A. vera 40% ointmentinduced quicker skin healing and decreased the inflammatory changes caused by S. aureus inoculation, based on biochemical and histopathological changes reflective of its curative efficiency. A. vera 40% ointment may be a suitable alternative to antibiotics for the treatment of staphylococcal pyoderma in dogs.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 89%