Haematological actions of androgens

Warren, Annabelle M.; Grossmann, Mathis

doi:10.1016/j.beem.2022.101653

Cited by 24 publications

(13 citation statements)

References 85 publications

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“…Hemoglobin concentration started to decrease with age after reaching the peak. Hemoglobin decreased with age in male subjects, and this decrease may be due to a progressive loss of androgens, as androgens stimulate increased production of red blood cells [ 24 ]. In females, the decreasing tendency was also reported by Taneri PE [ 25 ], this could be due to reduction in expression of androgens with age, reduced iron intake from weight loss and blood loss during menstruation [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Age and sex trend differences in hemoglobin levels in China: a cross-sectional study

Cao

Ren

et al. 2023

BMC Endocr Disord

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Background Both age and gender are the influence factors of hemoglobin concentration. However, the changing trend of hemoglobin levels between males and females with age remains unclear. This study aimed to explore their changing characteristics in different genders. Methods A cross-sectional study was conducted in Physical Examination Center of the First Affiliated Hospital of Wannan Medical College in Wuhu, China from 2014 to 2016. The generalized linear model was applied to explore the relationship between age, gender and hemoglobin levels. Results Among the 303,084 participants, the mean age for females and males was 46.9 ± 13.4(15–98) and 48.1 ± 13.7(14–98) years old, respectively. Generalized smoothing splines showed that hemoglobin levels increased up to age 25 and then decreased in men; in women the levels increased up until age 20, and then decreased, with slight increase again (β = 0.244, P < 0.01). After dividing all participants into hyperglycemia and normal groups, only the normal female group showed a significant upward trend (β = 0.257, P < 0.01) between ages 50–59. Conclusions Hemoglobin concentration changes with age and the curve is different in males and females. The slightly upward trend of female hemoglobin in the age range of 50–59 years old should be considered in developing the reference range of hemoglobin making.

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Section: Discussionmentioning

confidence: 99%

Age and sex trend differences in hemoglobin levels in China: a cross-sectional study

Cao

Ren

et al. 2023

BMC Endocr Disord

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“…In addition, testosterone and its metabolites, which are normally found in higher concentrations in males, are important stimulators of hematopoiesis. The number of platelets may be raised by androgens, and there may be an effect on platelet function with increased expression of the thromboxane-A2 receptor, which can promote platelet aggregation [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Thermal Stress on Thermoregulation, Hematological and Hormonal Characteristics of Caracu Beef Cattle

Abduch

Pires

Souza

et al. 2022

Animals

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This study evaluated the influence of environmental temperature on thermoregulation, hormonal, and hematological characteristics in Caracu cattle. Blood samples, hair length, coat and muzzle colors, rectal (RT), and surface temperatures were collected from 48 males and 43 females before (morning) and after sun exposure for eight hours (afternoon). Infrared thermography (IRT) was used to identify superficial temperature that exhibits a high correlation with RT. Hematological parameters, hormone concentrations, RT, and the superficial temperature obtained by IRT that exhibited the highest correlation with RT were evaluated by variance analysis. Regarding IRT, the lower left side of the body (LS) showed the highest correlation with the RT. Interaction between period and sex was observed for LS, cortisol, and eosinophils. Cortisone, progesterone, and RT were influenced by period and sex. Neutrophils and segmented neutrophils were influenced by the period, which showed the highest concentrations after sun exposure. Platelets, leukocytes, lymphocytes, and monocytes were influenced by sex. Heat stress changes several physiological characteristics where males and females exhibited differences in their responses to heat stress. Furthermore, most characteristics evaluated remained within the regular values observed for taurine Creole breeds, showing that Caracu is adapted to tropical climates.

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“…The expression of SLC7A11 in PCa is increased compared with normal, which may be a strategy to combat ferroptosis [ 32 ]. The effect of erastin (a ferroptosis inducer) was found to be more pronounced in SLC7A11 knockout PCa cells compared to controls [ 33 ]. There is a positive correlation between SLC7A11 and NRF2 [ 34 ].…”

Section: Glutathione Metabolism In Pcamentioning

confidence: 99%

Ferroptosis landscape in prostate cancer from molecular and metabolic perspective

et al. 2023

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Prostate cancer is a major disease that threatens men’s health. Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. It is necessary to find new effective anticancer methods. Ferroptosis is a novel iron-dependent programmed cell death that plays a role in various cancers. Understanding how ferroptosis is regulated in prostate cancer will help us to use it as a new way to kill cancer cells. In this review, we summarize the regulation and role of ferroptosis in prostate cancer and the relationship with AR from the perspective of metabolism and molecular pathways. We also discuss the feasibility of ferroptosis in prostate cancer treatment and describe current limitations and prospects, providing a reference for future research and clinical application of ferroptosis.

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Haematological actions of androgens

Cited by 24 publications

References 85 publications

Age and sex trend differences in hemoglobin levels in China: a cross-sectional study

Age and sex trend differences in hemoglobin levels in China: a cross-sectional study

Effect of Thermal Stress on Thermoregulation, Hematological and Hormonal Characteristics of Caracu Beef Cattle

Ferroptosis landscape in prostate cancer from molecular and metabolic perspective

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