Haematological alterations in the cardiac patient after use of an autotransfusion system

Oliveros, Manuel Luque

doi:10.1016/j.redare.2017.12.004

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Thus, our data indicate that contact of blood with cotton during cardiac surgery with heart lung machine provokes a material‐induced inflammatory activation. Diverse autotransfusion systems on the market remove dead or activated cells and proteins to a certain extent, but not completely so that an activation cascade could potentially be triggered systemically culminating in SIRS and its consequences . When the heart lung machine is connected or large vessels are injured, the blood volume exiting the body is far too large to be first washed in a cell saver.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory potential of cotton‐based surgically invasive devices: Implications for cardiac surgery

et al. 2018

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Cotton-based surgical invasive devices with their desired hemostyptic properties have been used for decades in the surgical field. However, in cardiac surgery using the heartlung machine with direct retransfusion of suction blood, activated blood may re-enter the circulation without filtration and may trigger a cascade reaction leading to systemic inflammation and thrombosis. We therefore set out to evaluate the inflammatory potential of untreated and pyrogen-impregnated cotton-based surgical invasive medical devices. After incubation of the swabs with whole blood or PBMC, the cell-free supernatant was investigated for IL1β and IL6. While the reaction of human whole blood toward cotton swabs could not be influenced by any sterilization technique, dry heat and gammairradiation were able to diminish the inflammatory reaction of PBMC toward the material and the used pyrogens. In conclusion, using PBMC in direct contact to cotton we are the first to establish a suitable test method for quantification of the pyrogenic/inflammatory activity of this material. The unaltered reaction of whole blood, however, suggests a crosstalk of cells and plasma proteins in the inflammation activation that is not prevented by sterilization of the swabs. This new in vitro testing methodology may help to better display the clinical situation during development of new materials.

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Section: Discussionmentioning

confidence: 99%

Inflammatory potential of cotton‐based surgically invasive devices: Implications for cardiac surgery

et al. 2018

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“…Ранее в литературе обсуждался вопрос о возможном развитии системной гипокоагуляции из-за попадания антикоагулянта (гепарин, цитрат), используемого для стабилизации излившейся крови, в кровь оперируемого больного в результате реинфузии [8]. Однако последующие исследования убедительно показали, что в процессе обработки раневой крови на селл-сейвере происходит полное отмывание антикоагулянта, а сам реинфузат не вызывает серьезных нарушений в системе гемостаза у пациента [38][39][40].…”

Section: осложнения методики реинфузии кровиunclassified

Blood reinfusion in surgery. State of art. Review

Lubnin

Gromova

2019

Annals of Critical Care

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В работе на основании данных литературы и собственного опыта анализируется современное состояние проблемы реинфузии крови в хирургии. Рассмотрены технические решения, методические подходы, аппаратура для проведения реинфузии крови у хирургических больных. Также рассмотрены такие аспекты проблемы, как показания, противопоказания и особенности применения методики в различных областях хирургии. Ключевые слова: реинфузия крови в хирургии, технические решения, показания и противопоказания, возможные осложнения u Для корреспонденции: Лубнин Андрей Юрьевичд-р мед. наук, профессор, руководитель отдела анестезиологии, реанимации и интенсивной терапии ФГАУ «НМИЦ нейрохирургии им. акад. Н.Н. Бурденко» МЗ РФ,

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Haematological alterations in the cardiac patient after use of an autotransfusion system

Cited by 2 publications

References 26 publications

Inflammatory potential of cotton‐based surgically invasive devices: Implications for cardiac surgery

Inflammatory potential of cotton‐based surgically invasive devices: Implications for cardiac surgery

Blood reinfusion in surgery. State of art. Review

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