Haematological and biochemical findings in bovine post-parturient haemoglobinuria and the accompanying Heinz-body anaemia

De, Gardner; Martinovich, D.; Da, Woodhouse

doi:10.1080/00480169.1976.34297

Cited by 11 publications

(7 citation statements)

References 7 publications

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“…The low Mo concentrations in the control treatment indicate that if no basal Mo is applied, then the lime-induced increase in Mo availability would be a mechanism for lime responses on this soil. However, the increase in Mo concentrations to high values (>1 | Xg g" 1 ) when lime and Mo were applied could contribute to molybdenum-induced Cu deficiency in grazing animals (Smith & Coup 1973;Gardner et al 1976). Smith & Edmeades (1983b) reported that the Mn levels required to reduce plant growth were 570 (Xg mg" 1 for clover and 1110 (xg mg ' for grass.…”

Section: Discussionmentioning

confidence: 99%

“…However, lime could affect feed quality if large changes in the grass clover mix within the sward occurred. Lime application in late autumn (May) has been reported to increase the incidence of hypomagnesemia (Thomson 1982) and is suspected to increase the incidence of molybdenum-induced Cu deficiency in grazing animals (Smith & Coup 1973;Gardner et al 1976).…”

Section: Introductionmentioning

confidence: 99%

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Investigation into the mechanisms causing lime responses in a grass/clover pasture on a clay loam soil

Wheeler

1998

New Zealand Journal of Agricultural Research

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A mowing trial was conducted on the Mangatea clay loam (a yellow-grey earth or Umbric Dystrochrept fine hallositic mesic) to examine the mechanisms causing lime responses in a grass/ clover pasture. The trial site was located on a sheep and beef farm 8 km south of Te Kuiti, New Zealand. The site generally had cool winters and warm moist summers, with an annual rainfall of about 1400 mm. The treatments consisted of 3 lime rates (0, 5000, 10 000 kg ha -1 ) in the absence of P and 6 lime rates (0, 1250, 2500, 5000, 7500, 10 000 kg ha -1 ) in the presence of P (50 kg P ha -1 yr -1 ), all in the presence of sodium molybdate (Mo), and an additional treatment where P was applied in the absence of lime and Mo. Lime increased grass yield but decreased clover yield for the first 2 years after application. In Years 3 and 4, the responsiveness of the grass decreased and that of clover increased. Lime increased net N mineralisation by up to 58 kg ha -1 , resulting in increased grass growth. Plant P uptake in both grass and clover also increased when lime was applied. However, yield responses were only seen in summer in clover when plant P concentrations in clover were less than 3.0 mg g -1 . The lime-induced increase in Mo availability would contribute to lime responses if basal Mo was not applied. Subsoil Al toxicity, particularly in summer, was limiting growth in some parts of the trial. However, there was no evidence that Mn toxicity was limiting yield, nor of any lime-induced trace nutrient deficiencies. Results from the application of P and Mo indicate that there was at least a 6-month delay in the transfer of N from clover to grass, with about 30% of the extra clover N uptake in Year 1 being transferred to extra N uptake in grass in Year 2.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation into the mechanisms causing lime responses in a grass/clover pasture on a clay loam soil

Wheeler

1998

New Zealand Journal of Agricultural Research

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“…Notwithstanding spherocytosis and increased osmotic fragility are not pathognomonic for intracellular ATP or P depletion of RBCs, but have also been documented in patients of other species suffering from other conditions such as autoimmune‐mediated hemolytic anemia or poisoning with aniline or naphthalene. Studies investigating osmotic resistance of RBCs in cattle with clinical PPH yielded conflicting results . Furthermore, hypophosphatemia has been reported in many but not all cases of PPH and response to treatment with phosphate salts is variable in affected animals .…”

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confidence: 99%

Red Blood Cell Phosphate Concentration and Osmotic Resistance During Dietary Phosphate Depletion in Dairy Cows

Grünberg

Mol

Teske

2014

Veterinary Internal Medicne

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BackgroundHypophosphatemia in early lactating dairy cows has been implicated as primary cause for postparturient hemoglobinuria in cattle. Decreased availability of phosphorus has been proposed to reduce adenosine triphosphate synthesis of erythrocytes and thereby reduce osmotic resistance of these cells.Hypothesis/ObjectivesTo study the effect of phosphorus depletion on the phosphate concentration ([Pi]) in plasma and erythrocytes and the osmotic resistance of erythrocytes and to determine the association between plasma [Pi] and erythrocyte [Pi].AnimalsTen healthy midlactating dairy cows in their 3rd to 5th lactation.MethodsProspective study. Dietary phosphorus depletion for 5 weeks followed by phosphorus supplementation. Plasma and erythrocyte [Pi] and erythrocyte osmotic resistance were measured. Four cows underwent continuous dextrose infusion at the end of phosphate depletion to exacerbate hypophosphatemia.ResultsDietary P depletion resulted in a marked decline of the plasma [Pi] from 4.1 ± 1.0 mg/dL to a nadir of 1.7 ± 0,5 mg/dL, but did not alter erythrocyte [Pi] or osmotic resistance. Similarly, dextrose infusion induced a decline of the plasma [Pi] from 2.4 ± 0.5 mg/dL to 1.5 ± 0.5 mg/dL, but had no effect on erythrocyte [Pi] or osmotic resistance.Conclusions and Clinical ImportanceIn cattle, marked hypophosphatemia induced by dietary P depletion was neither associated with a decline in erythrocyte [Pi] nor with decreased osmotic resistance of erythrocytes. Phosphorus depletion alone is therefore unlikely to cause intravascular hemolysis and the plasma [Pi] is an unreliable index for the intracellular [Pi] of erythrocytes.

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“…Algunos animales afectados presentaron bajas concentraciones de cobre en hígado y sangre (7,20) los otros metabolitos analizados dentro de los rangos de referencia establecidos por el laboratorio (18)(Tabla 3).…”

Section: Discussionunclassified

“…las concentraciones de cobre en hígado y sangre tanto de los animales muertos como de otros de los rebaños afectados. Por otro lado, las concentraciones de colesterol y proteínas plasmáticas fueron similares a animales no afectados (20).…”

Section: Discussionunclassified

Hemoglobinuria posparto en vacas de tres rebaños lecheros de la región del Bío-Bío, Chile

Noro

2011

Rev MVZ Córdoba

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RESUMENLa hemoglobinuria posparto es una enfermedad metabólica esporádica que presentan las vacas lecheras, manifestándose dentro de las 6 semanas posparto asociada al rápido incremento de la producción de leche al inicio de la lactancia. Se caracteriza por una anemia aguda regenerativa por hemólisis intravascular con hemoglobinuria. Entre los factores que predisponen a su presentación están la ingesta de una dieta carente en fósforo, cobre o selenio, o bien concomitante a la presencia de agentes hemolíticos en plantas crucíferas como el nabo o colza. El trabajo describe aspectos relacionados a la presentación de brotes de la enfermedad en tres rebaños lecheros de la región del Bío-bío, Chile, con hipofosfatemia asociada a la incorporación de derivados de la remolacha azucarera en la dieta. Palabras clave: Hemoglobinuria, hipofosfatemia, parto, vacas lecheras (Fuentes: CAB, AIMS). ABSTRACTBovine postpartum hemoglobinuria is a metabolic disorder observed sporadically in dairy cows up to 6 weeks postpartum associated to increasing milk production. It is characterized by an acute intravascular hemolytic anemia with hemoglobinuria. It presentation has been associated to diets with low content of phosphorus, cooper or selenium, as well as the ingestion of hemolytic substances present in some plants of the genus Brassica commonly used as forages (turnips, rapeseed). The aim of this work is to describe clinical aspects related to the presentation of this disease in three dairy herds with hypophosphatemia induced by the inclusion of sugar beet by-products in the diet.

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Haematological and biochemical findings in bovine post-parturient haemoglobinuria and the accompanying Heinz-body anaemia

Cited by 11 publications

References 7 publications

Investigation into the mechanisms causing lime responses in a grass/clover pasture on a clay loam soil

Investigation into the mechanisms causing lime responses in a grass/clover pasture on a clay loam soil

Red Blood Cell Phosphate Concentration and Osmotic Resistance During Dietary Phosphate Depletion in Dairy Cows

Hemoglobinuria posparto en vacas de tres rebaños lecheros de la región del Bío-Bío, Chile

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