Haematological and histopathological effects of oil from castor seeds (Ricinus communis Linn.) on albino-rats

Momoh, A. O.; Oladunmoye, M. K.; Adebolu, T. T.

doi:10.5897/jpp11.077

Cited by 13 publications

(12 citation statements)

References 4 publications

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“…This shows that the A. boonei stem bark powder has slight effect on the liver without any hepatocellular damage since necrosis was not noticed at this concentration for animals. Momoh et al (2012) stated that at low concentration, any substance which have effect such as the one noticed above is generally safe for animal and will not cause any negative effect when used even over a long period of time. The group fed with 10% A. boonei stem bark powder had necrosis which is an indication that this concentrations is not safe for animals.…”

Section: Discussionmentioning

confidence: 99%

Toxicological and Histopathological Effects of Cheese Wood, Alstonia boonei De Wild Stem Bark Powder used as Cowpea Protectant against Cowpea Bruchid, Callosobruchus maculatus (Fab.) [Coleoptera: Chrysomelidae] on Albino Rats.

Ileke

Odeyemi²,

Ashamo³

2014

ijmms

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Toxicological and histopathological effects of Alstonia boonei stem bark powder on albino rats liver and kidney functions were investigated using standard methods. After two weeks of acclimatization, the rats were randomly divided into four (I-IV) groups of six animals each. Group I was fed with Basal Diet, group II-IV were for 30 days with Basal Diet containing 1%, 4% and 10% A. boonei stem bark powder, respectively. Blood was rapidly collected by direct heart puncture and the plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein, urea and creatinine contents were determined using commercially-available kits. The levels of these biochemical functions were also determined in the liver and kidney. The A. boonei stem bark powder at 10% concentration caused oxidative liver and kidney damages. Histopathological results of the liver shows that the group fed with 4% A. boonei stem bark powder had normal hepatocytes. The group fed with 10% A. boonei stem bark powder had necrosis. The results of the present study showed that the supplementation of 1% and 4% A. boonei stem bark powder to the diets of rats for 30 days did not change the biochemical parameters of liver and kidney as well as histopathological investigation which illustrated normal architecture of liver and kidney.

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Section: Discussionmentioning

confidence: 99%

Toxicological and Histopathological Effects of Cheese Wood, Alstonia boonei De Wild Stem Bark Powder used as Cowpea Protectant against Cowpea Bruchid, Callosobruchus maculatus (Fab.) [Coleoptera: Chrysomelidae] on Albino Rats.

Ileke

Odeyemi²,

Ashamo³

2014

ijmms

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“…This is because; the extract may possess a portion of the ricinoleic acid, the active component of castor oil [11]. Momoh et al [12], showed that neutrophils were higher in the experimental with a value of 30% when compared with that of the control with a value of 27%. Since high neutrophils are an indication of systemic infection on animals, the ill is the cause.…”

Section: Discussionmentioning

confidence: 99%

Hematological and biochemical changes in rabbits exposed to castor oil (Ricinus communis) under experimental conditions

Ahmed

2017

MJS

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In the last few decades there has been an exponential growth in the field of herbal medicine. One such medicinal plant is Ricinus communis (Euphorbiaceae), which is commonly known as castor. All parts of the plant are important phloem, bark, leaves, flowers, seed and oil. The study was conducted on 15 mature rabbitsof either sex of 1-2 kg body weight and 1-2 years old. The animals were divided into three groups of 5 animals each. Animals of group I were exposed orally to ricin extract at a dose rate of 0.5 mg /kg b.wt. daily for 14 days, while those of group II were exposed orally to aqueous leaves extract 0.5mg /kg b.wt daily for 14 day, mean while those of group III were left as a control group not exposed. The dependent parameters in the study were hemoglobin (Hb) concentration, total erythrocytes count, packed cells volume (PCV%), erythrocytes indices mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), Total and differential leucocytes count (TLC and DLC), in addition to some biochemical tests of blood serum which obtained at day 14 th post exposure. The results of the study were revealed that the ricin extract and leaf extract exhibited an effects on hematological pictures as the erythrocytes counts, erythrocytes indices, Hb concentration and PCV% decreased and the obvious effects were in the 14 th day. Ricin extract was less effects on many dependent parameters in comparison with aqueous leaf extract. Total leucocytes count, neutrophils % was increased in both ricin and leaf extract, and the increasing were higher in the 7 th day in Ricin extract group. The lymphocytes% was decreased. While monocytes, eosinophils, and basophils % did not show any significant changes in all groups. Neutrophil /lymphocyte (N/l), and monocyte /lymphocyte (M/l) increased in both exposed groups. Cholesterol (Chol), Triglyceride (TG)were increased, while total protein (TP)was decreased, Albumin (Alb), Cortisol (Cort), Total serum bilirubin (TSB) and Alanine aminotransferase (ALT)did not changed. Aspartate aminotransferase (AST) value was increased, while Adenosine phosphatase (AP) value was deceased. In conclusion castor oil due to its content of ricin exhibit an effects on hematological and biochemical parameters that depended in the study, and the leaves extract was higher than seed extract in its effects.

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“…Standard methods for anti-nutrient screening (phenol, flavonoids, tannins alkaloids and saponins) were employed according to Adewole, et al (2015), Royal Society of Chemistry ( 2002) as modified by (Momoh, et al, 2012), andObadoni andOchuko (2001).…”

Section: Determination Of the Anti-nutrient Composition Of Justicia S...mentioning

confidence: 99%

Effect of Processing Methods on Nutrient Andantinutrient Composition of Justicia Secunda Leaves

EFFIONG, I. D.,

1EJINKEONYE, Uju. B.,

EJINKEONYE, I.G

2024

njhe

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Justicia secunda as a medicinal plant belongs to the family of Acanthaceae ,the leaf is an under-utilized medicinal vegetable that is believed and utilized as blood tonic by the local people and especially among the sect of some religious people that refuse blood infusion in medical conditions. This study examined the effect of processing methods on the nutrient and phytochemical composition of justicia secunda leaves. The leaves were subjected to blanching pre-treatment before sun drying for 72 hrs oven drying at 55 0C for 48 hrs and air drying for 120 hrsThe proximate, vitamins, minerals and phytochemical analysis were conducted on the samples using standard procedures. The results varied significantly (p<0.05) in all the parameters measured according to the different processing treatments. Proximate composition of the samples ranged for crude protein (18.20-21.73%), crude fat (7.80-9.10%), crude fibre (12.00-14.90%), ash (15.50-17.40%), moisture (8.00-9.00%) and carbohydrate (27.98-35.50%). Mineral composition ranged for calcium (18.20-34.10 mg/100g), magnesium (47.11-54.29 mg/100g), sodium (126.43-136.47 mg/100g), potassium (425.49-453.03 mg/100g), phosphorus (135.40-145.76 mg/100g) and iron (33.07-38.94 mg/100g). Vitamin composition showed that thiamine (B1) ranged from 0.04-0.31 mg/100g, riboflavin (B2) (0.21-1.7 8mg/100g), niacin (B3) (0.49-1.89 mg/100g), vitamin C (6.31-19.48 mg/100g), while vitamin E ranged from (1.97-6.78 mg/100g). Anti-nutrient contents ranged for tannin (4.82-16.89 mg/100g), phenol (7.41-19.23 mg/100g), alkaloids (2.05-7.07 mg/100g) flavonoids (4.90-9.85 mg/100g) and saponin (3.25-8.35 mg/100g. Overall, the results revealed that air drying methods retained greater concentrations of fibre, minerals, vitamins and anti-nutrients than other processing methods. The high micro-nutrient contents of iron, anti-nutrient compounds and B group of vitamins in this processed vegetable reveals why it is used intuitively by the traditional people to boost health conditions due to the functional roles of iron, phytonutrients and B group of vitamins in heamopoisis in preventing morbidity and mortality especially among children.

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Haematological and histopathological effects of oil from castor seeds (Ricinus communis Linn.) on albino-rats

Cited by 13 publications

References 4 publications

Toxicological and Histopathological Effects of Cheese Wood, <i>Alstonia boonei</i> De Wild Stem Bark Powder used as Cowpea Protectant against Cowpea Bruchid, <i>Callosobruchus maculatus</i> (Fab.) [Coleoptera: Chrysomelidae] on Albino Rats.

Toxicological and Histopathological Effects of Cheese Wood, <i>Alstonia boonei</i> De Wild Stem Bark Powder used as Cowpea Protectant against Cowpea Bruchid, <i>Callosobruchus maculatus</i> (Fab.) [Coleoptera: Chrysomelidae] on Albino Rats.

Hematological and biochemical changes in rabbits exposed to castor oil (Ricinus communis) under experimental conditions

Effect of Processing Methods on Nutrient Andantinutrient Composition of Justicia Secunda Leaves

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