Haematological and platelet effects of butylated hydroxytoluene (BHT, E321)

Cottrell, S.; Andrews, C. M.; Clayton, David J.; Wild, Barbara; Powell, C.J.

doi:10.1007/bf00368276

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Self-recovery group and treated groups by either BPF, BHT and OPZ showed recovery of CBC by increases of all CBC except neutrophils. This improvement in CBC could be returned to promotion of the activity of proinflammatory cascade reactions (Takahashi and Hiraga 1984;Cottrell et al 1994;Petricevich and Pena 2002;Salman et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Comparative ameliorative actions of extracted bradykinin potentiating fraction from cobra snake venom and synthetic antioxidants on hepatic tissue of aflatoxicosed rats

Nassar

Mahgoub

Omar

et al. 2020

Journal of Applied Animal Research

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Mycotoxins are secondary metabolites produced by Aspergillus, Penicillium and other genera which contaminate food and exhibit hazardous effects on humans and animals. Aflatoxins (AFs) caused liver necrosis, fibrosis. In the present study, we planned to evaluate the action of bradykinin potentiating factor (BPF) extracted from Egyptian cobra snake venom and synthetic antioxidants; butylated hydroxytoluene (BHT) and oltipraz (OPZ) on the hepatic tissue of aflatoxicosed rats. Aflatoxicosis caused a significant increase of nitric oxide (NO) and lipid peroxidation as malondialdehyde (MDA) associated with a significant decrease in the level of total thiols, glutathione (GSH), and the activities of glutathione peroxidase (GPx) and transferase (GST). In addition to a decrease in the counts of white blood cells (WBCs), lymphocytes (LYM), monocytes (MONO), eosinophils (EOS), red blood cells (RBCs) and an increase in neutrophil counts (NEUT) as well as a significant decrease in the gene expression of hepatic interleukin-1β (Il-1β). The previous changes were confirmed by histopathological alterations. Treatment of aflatoxicosed rats with any of BPF, BHT or OPZ resulted in amelioration of the oxidative stress parameters, blood picture and hepatic IL-1β with improvement in histological features. In conclusion, either BPF, BHT or OPZ can be used for the treatment of aflatoxicosis.

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Section: Discussionmentioning

confidence: 99%

Comparative ameliorative actions of extracted bradykinin potentiating fraction from cobra snake venom and synthetic antioxidants on hepatic tissue of aflatoxicosed rats

Nassar

Mahgoub

Omar

et al. 2020

Journal of Applied Animal Research

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“…Lyophilized probiotics use the antioxidant butylated hydroxytoluene (BHT) as preserver (CASTRO, 2017). In mice, BHT at 3 g/kg may originate hepatocellular carcinomas, increases platelet count, Er, Ht and Hb and decreases leukocytes (COTTRELL et al, 1994). In Rhesus monkeys, 50 mg/kg concentrations during 2 years did not significantly influence Hb, Ht, and white and red blood cells (EFSA, 2012).…”

Section: Discussionmentioning

confidence: 99%

Hematological parameters and frequency of salmonella spp. in swabs of caiman yacare after of probiotics

Carvalho¹,

Bergamo²,

Aleixo³

et al. 2018

RICA

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The C. yacare placed in breeding conditions have a preserved genetic pool, which requires the enhancement of its zootechnical characteristics to solve some obstacles. Among them is the natural occurrence of Salmonella spp. in wild C. yacare. To address this problem, some breeders have adopted the use of probiotics to reduce Salmonella spp. in the digestive tube of crocodilians. The purpose of this study was to verify whether the addition of probiotics in animal feed reduces the isolation frequency of Salmonella spp. in cloacal swabs and to assess whether the additive interferes with the hematology and the complement system. During an 18-month period, four groups of caimans received 0% (control group), 0.25%, 0.5% and 1% of probiotic supplement. The probiotics did not reduce the isolation frequency of Salmonella spp. We have identified directly proportional relation between probiotic concentration and Hemoglobin concentration (Hb) and Mean Corpuscular Hemoglobin Concentration (MCHC) and inversely proportional relation to the total concentration of Eosinophils and Heterophils. Finally, we verify that the prolonged use of probiotics at 0.25% concentration is safe and increase the activity of the complement system.

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A potential role for bht in studies on the regulation of thrombopoietin

Cottrell¹,

Powell²

1994

Comp Haematol Int

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Haematological and platelet effects of butylated hydroxytoluene (BHT, E321)

Cited by 3 publications

References 16 publications

Comparative ameliorative actions of extracted bradykinin potentiating fraction from cobra snake venom and synthetic antioxidants on hepatic tissue of aflatoxicosed rats

Comparative ameliorative actions of extracted bradykinin potentiating fraction from cobra snake venom and synthetic antioxidants on hepatic tissue of aflatoxicosed rats

Hematological parameters and frequency of salmonella spp. in swabs of caiman yacare after of probiotics

A potential role for bht in studies on the regulation of thrombopoietin

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