Haematological changes in adjuvant disease in the rat. II. Iron metabolism and 51Cr erythrocyte survival.

Haematological changes in adjuvant disease in the rat. I. Peripheral blood and bone marrow after repeated injections of Freund's adjuvant.

“…These signs suggest that haemolysis and/or chronic blood loss may assist in the pathogenesis of anaemia after repeated injections of adjuvant. Attempts to elucidate these questions are the subject of further studies (Mikolajew, Kuratowska, Kossakowska, Plachecka, and Kopec, 1969).…”

Influence of iron dextran on adjuvant arthritis in the rat.

“…This increase in the severity of the arthritis was not accompanied by any increased loss of weight nor by any significant change in the plasma iron values compared with the female. Plasma iron values mirror the severity of the arthritis in adjuvant disease in the rat (Lukens, Cartwright, and Wintrobe, 1967;Mikolajew, Kuratowska, Kossakowska, Plachecka, and Kopec, 1969) as they do in adult rheumatoid arthritis (Mowat, Hothersall, and Aitchison, 1969). Such differences in the plasma iron values between salineand iron-treated arthritic animals and saline and iron-treated controls have been confirmed in this study.…”

A sardine oil‐rich diet increases iron absorption but does not compensate the hypoferremia associated with inflammation

“…When animals are fed diets supplemented with n-3 PUFA to reduce inflammation, an increase in iron absorption due to the high erythrocyte turnover has been reported (11). Moreover, inflammation in rats is associated with a reduction in iron absorption (3). Thus, two opposite effects on iron absorption would take place.…”

“…The alterations in plasma iron status observed in inflammatory disorders are caused by a blockade of iron in storage organs (1,2), a decrease in iron absorption (3), and an increase in ferritin synthesis under the influence of interleukin-1 and tumor necrosis factor (4,5). n-3 PUFA have beneficial effects on inflammation (6) and rheumatoid arthritis (7), since they may reduce the production of inflammatory mediators by cyclooxygenase (8,9) or lipoxygenase (8), and reduce superoxide anion production by polymorphonuclear leukocytes from an inflammatory exudate (10).…”