Haematological parameters and lipid profile abnormalities among patients with Type-2 diabetes mellitus in Ghana

Antwi‐Baffour, Samuel; Kyeremeh, Ransford; Boateng, Samuel Owusu; Annison, Lawrence; Seidu, Mahmood Abdulai

doi:10.1186/s12944-018-0926-y

Cited by 35 publications

(28 citation statements)

References 44 publications

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“…Our findings revealed that the LDL/HDL ratio values in the study population were higher in men comparing to women, however, underneath the target level for both men (3.0) and women (2.5) as recognized by Aderibigbe et al (2018) [24]. These outcomes are in accordance with conclusions reported from Ghana [25] and Iran [26] but different from conclusions of Ballotari et al (2017) from Italy enlightening that diabetes constitutes a higher cardiovascular risk for women than for men [27]. The comparison of the conventional lipid parameters (TC, LDL and TG) between men and women according to the HbA1c levels indicated divergent results.…”

Section: Discussionsupporting

confidence: 92%

Impact of Gender Differences and Glycated Haemoglobin on Atherosclerosis Risk in Type 2 Diabetic Patients from North Western Algeria

2020

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In type 2 diabetic patients, blood lipids and lipid ratios have been proven to be associated with atherosclerosis risk; however, results about the effect of gender differences had not been fully conclusive. In this transversal comparative study, a total of 129 adult type 2 diabetic patients (54 men and 75 women), from north western Algeria, was included to highlight the impact of gender differences on atherosclerosis risk (assessed by lipid ratios) according to their diabetic profile. Comparing between the two genders, no significant differences (p>0.05) were noted on diabetes duration, central obesity, body mass index and blood pressures. Moreover, the basic biochemical parameters of both glycaemic and lipid metabolism were not meaningfully divergent. However, higher significant values (p<0.05) of body weight, height, HbA1c levels, HDL and lipid ratios (TC/HDL, LDL/HDL and TG/HDL) were observed in male patients comparing to females. According to the HbA1c levels (HbA1c<7%vs. HbA1c≥ 7%); notable higher CT/HDL, LDL/HDL and TG/HDL in male patients comparing to women were found. The rates of these three lipid ratios were often higher in both classes of HbA1c. The consideration of gender differences is very important for prevention, diagnosis, treatment and management of atherosclerosis and CVD. The disparity in atherogenic risk, in both genders, estimated by lipid ratios need to be critically examined. Further, interventional studies are needed to determine how sex can modulate the impacts of diabetes control parameters on atherosclerosis risk.

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Section: Discussionsupporting

confidence: 92%

Impact of Gender Differences and Glycated Haemoglobin on Atherosclerosis Risk in Type 2 Diabetic Patients from North Western Algeria

2020

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“…However, it can be speculated that this relationship results from an abnormal lipid profile in patients with high-normal TSH. Such a hypothesis can be supported by recently published observations performed concerning patients with type-2 diabetes mellitus in whom proatherogenic parameters of lipid profile correlated positively with the lymphocyte level [21].…”

Section: Discussionmentioning

confidence: 54%

Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study

Karbownik-Lewińska

Stępniak

Żurawska

et al. 2020

IJERPH

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High-normal TSH can be associated with metabolic abnormalities and infertility. Aims of this study are to analyze retrospectively if routinely measured blood laboratory and anthropometric parameters differ between women of reproductive age with TSH < 2.5 mIU/L and with TSH ≥ 2.5 mIU/L. Retrospective analysis was performed in 466 female inpatients, aged 13–51, hospitalized in an endocrine department. The group of 280 patients with normal thyroid tests (TSH 0.27-4.2 mIU/L; normal FT3 and FT4) was selected and it was divided into two subgroups, i.e., with TSH < 2.5 mIU/L and TSH ≥ 2.5 mIU/L (n = 66; 23.6%). After excluding patients on L-thyroxine treatment (n = 240), those with TSH ≥ 2.5 mIU/L constituted 22.92% (n = 55). In the group of 280 patients with normal thyroid tests, an abnormally high concentration of triglycerides and an abnormally low HDLC/cholesterol ratio occurred more frequently in women with TSH ≥ 2.5 mIU/L than those with TSH < 2.5 mIU/L (17% vs. 7%, p = 0.017; 14% vs. 5%, p = 0.015, respectively). Increased concentration of thyroid antibodies, i.e., TPOAb, occurred more frequently in patients with TSH ≥ 2.5 mIU/L than those with TSH < 2.5 mIU/L (27% vs. 9%, p = 0.001). The same differences were found in the group of 240 patients after excluding those on L-thyroxine treatment. Blood lymphocyte concentration was the only independent linear parameter associated with TSH ≥ 2.5 mIU/L (OR = 1.551, p = 0.024) but only in the group of 280 patients with normal thyroid tests. TSH concentration correlated positively with blood lymphocyte (r = 0.129, p = 0.031) and TPOAb (r = 0.177, p = 0.005) concentrations but only in the group of 280 patients with normal thyroid tests. Less favorable lipid profiles and a higher prevalence of thyroid antibodies in women of reproductive age with high-normal TSH suggests that L-thyroxine treatment should be considered in such patients. The significance of a positive association between high-normal TSH and blood lymphocytes requires further evaluation.

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“…A study in Ghana investigating blood lipids and T2DM showed that LDL and triglyceride levels increased with participant age and the number of males and also increased the risk of coronary heart disease. The parameters of all hematological examinations were statistically significant between the sexes [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot

Cui

Gao

Zhao

et al. 2020

BioMed Research International

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Objective. The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at providing approaches for the prevention and control of T2DM in combination with the characteristics of the local population. Methods. A case-control study was conducted including 406 Chinese participants, comprising 203 cases and 203 controls from various hospitals. Adiponectin (ADIPOQ) gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were detected using an improved multiple ligation detection reaction technique. Generalized multifactor dimensionality reduction (GMDR) and logistic regression were conducted to analyze the associations between adiponectin gene polymorphisms and T2DM, as well as the interactions between adiponectin gene polymorphisms and environmental factors. Results. ADIPOQ gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were associated with type 2 diabetes. Based on the haplotype of the five adiponectin gene single-nucleotide polymorphism (SNP) loci, we found that G-G-A-A-C was a susceptible haplotype of T2DM (P<0.05). Interaction analyses demonstrated associations between rs1501299 and central obesity (consistency=80%, P=0.011) and between rs266729 and rs182052 and central obesity (consistency=70%, P=0.011). Conclusions. Our findings indicate that there is an interaction between the ADIPOQ gene and central obesity, which provides new insights into the prevention and treatment of T2DM.

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Haematological parameters and lipid profile abnormalities among patients with Type-2 diabetes mellitus in Ghana

Cited by 35 publications

References 44 publications

Impact of Gender Differences and Glycated Haemoglobin on Atherosclerosis Risk in Type 2 Diabetic Patients from North Western Algeria

Impact of Gender Differences and Glycated Haemoglobin on Atherosclerosis Risk in Type 2 Diabetic Patients from North Western Algeria

Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study

Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot

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