Haematological Profile of Rats Administered With Aqueous Leaf Extract of Moringa Oleifera Following Thermooxidixed Palm Oil Diet Induced Toxicity

Okwari, OO; .G, Emerole C; Dasofunjo, K; H.C, Ezugwu; .J, Obi

doi:10.9790/3008-09124145

IOSRJPBS

2014

DOI: 10.9790/3008-09124145

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Haematological Profile of Rats Administered With Aqueous Leaf Extract of Moringa Oleifera Following Thermooxidixed Palm Oil Diet Induced Toxicity

OO Okwari¹,

Emerole C .G²,

K Dasofunjo³

et al.

Abstract: Abstract:In assessing the effect of haematological parameters of rats administered with aqueous leaf extract ofMoringa oleifera following thermooxidixed palm oil induced toxicity.

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2016

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Cited by 2 publications

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Aloe vera and garlic ameliorate deleterious consequences of thermoxidized palm oil diet on liver function and histology in rat

Ime

Ani

Nna

et al. 2016

NFS

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Purpose A plethora of publications have reported several cytotoxic effects associated with chronic consumption of thermoxidized palm oil. This research aims to investigate the effects of garlic and Aloe vera on liver function and hepatic cytoarchitecture in rats fed thermoxidized palm oil diet. Design/methodology/approach Thirty-five male albino Wistar rats weighing 150-180 g were used for this study. They were randomly assigned into five groups (n = 7): control, thermoxidized palm oil diet fed (TPO), TPO plus garlic juice (TPO + G), TPO plus Aloe gel (TPO + A) and TPO plus garlic/Aloe gel (TPO + G + A). The TPO diet was prepared by mixing 15 g of cooled thermoxidized palm oil with 85 g of rat feed. The juice and gel were orally administered at doses of 2.00 ml/kg and 19.12 ml/kg, respectively. After 3 months of feeding and administration, the animals were sacrificed using standard methods and blood collected via cardiac puncture for analysis. Findings Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase were significantly increased (p < 0.001) in the TPO group compared to the control. This increase was reduced (p < 0.001) in all the treated groups compared to TPO, with the greatest decrease (p < 0.001) seen in TPO + A. Total bilirubin was increased (p < 0.001) in the TPO group compared to the control, whereas there was a significant decrease (p < 0.001) in all the treated groups. Serum proteins and plasma fibrinogen were lowered (p < 0.001) in the TPO group compared to the control but increased progressively in all the treated groups. TPO induced prominent histopathological derangements of the liver tissues. However, there were marked improvements following treatment with garlic and Aloe vera. Originality/value The results obtained in this study have revealed that chronic consumption of thermoxidized palm oil is hazardous to health by inducing hepatotoxicity, as seen in increased ALT, AST and total and unconjugated bilirubin and decreased total protein. However, these debilitating effects were seen to be greatly ameliorated following garlic juice and Aloe vera gel administration. If these results are to be extrapolated to humans, then the chronic consumption of thermoxidized palm oil diet should be seriously discouraged.

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Aloe vera and garlic ameliorate deleterious consequences of thermoxidized palm oil diet on liver function and histology in rat

Ime

Ani

Nna

et al. 2016

NFS

View full text Add to dashboard Cite

show abstract

Antioxidant and Antifatigue Properties of the Aqueous Extract of Moringa oleifera in Rats Subjected to Forced Swimming Endurance Test

Lamou

Taïwe

Hamadou

et al. 2016

Oxidative Medicine and Cellular Longevity

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The effects of the aqueous extract of Moringa oleifera on swimming performance and related biochemical parameters were investigated in male Wistar rats (130–132 g). Four groups of rats (16 per group) were fed a standard laboratory diet and given distilled water, 100, 200, or 400 mg/kg of extract, respectively, for 28 days. On day 28, 8 rats from each group were subjected to the forced swimming test with tail load (10% of body weight). The remaining 8 rats per group were subjected to the 90-minute free swim. Maximum swimming time, glycemia, lactamia, uremia, triglyceridemia, hepatic and muscle glycogen, hematological parameters, and oxidative stress parameters (superoxide dismutase, catalase, reduced glutathione, and malondialdehyde) were measured. Results. M. oleifera extract increased maximum swimming time, blood hemoglobin, blood glucose, and hepatic and muscle glycogen reserves. The extract also increased the activity of antioxidant enzymes and decreased the blood concentrations of malondialdehyde. Furthermore, it decreased blood concentrations of lactate, triglycerides, and urea. In conclusion, the antifatigue properties of M. oleifera extract are demonstrated by its ability to improve body energy stores and tissue antioxidant capacity and to reduce the tissue build-up of lactic acid.

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Haematological Profile of Rats Administered With Aqueous Leaf Extract of Moringa Oleifera Following Thermooxidixed Palm Oil Diet Induced Toxicity

Abstract: Abstract:In assessing the effect of haematological parameters of rats administered with aqueous leaf extract ofMoringa oleifera following thermooxidixed palm oil induced toxicity.

Cited by 2 publications

References 11 publications

Aloe vera and garlic ameliorate deleterious consequences of thermoxidized palm oil diet on liver function and histology in rat

Aloe vera and garlic ameliorate deleterious consequences of thermoxidized palm oil diet on liver function and histology in rat

Antioxidant and Antifatigue Properties of the Aqueous Extract of Moringa oleifera in Rats Subjected to Forced Swimming Endurance Test

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